40 results about "Sertraline Hydrochloride" patented technology

A process for preparing amorphous paroxetine hydrochloride or sertraline hydrochloride is provided, which comprises preparing a solution in which paroxetine hydrochloride or sertraline hydrochloride and a water-soluble polymer are dissolved in a co-solvent of a volatile organic solvent and water. Said solution is dried to obtain a composition comprising amorphous paroxetine hydrochloride or sertraline hydrochloride and the water-soluble matrix.

The present invention is directed to (+)-cis-sertraline hydrochloride and methods of preparation. The present invention also includes processes for making sertraline having a cis / trans ratio greater than 3:1, greater than or equal to 8:1, or between about 8:1 and about 12:1, from the Schiff base of sertralone, sertraline-1-imine.

The invention relates to a liquid chromatographic separation and analysis method, and particularly relates to sertraline hydrochloride intermediates (+ / -)-tetralone and a chiral chromatographic splitting method thereof. The sertraline hydrochloride intermediates (+ / -)-tetralone and the chiral chromatographic splitting method thereof are provided, wherein the method comprises the following steps: taking the sertraline hydrochloride intermediates (+ / -)-tetralone, and dissolving in an aliphatic hydrocarbon-alcohol mixed liquid; and providing a polysaccharide chiral stationary phase, taking the solution for sample introduction, and carrying out chiral chromatographic separation under a condition with the aliphatic hydrocarbon-alcohol mixed liquid as a mobile phase. A coating type polysaccharide chiral stationary phase material is adopted for effective separation and analysis on the sertraline hydrochloride intermediates and enantiomers thereof, impurities brought by preparation of sertraline hydrochloride with a new process are effectively controlled, and the quality of raw material drugs and preparations can be further controlled.

This invention relates to crystalline polymorphs of sertraline hydrocloride, i.e. (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, denominated form I, II and V, and methods for their preparation.

This invention relates to a method for the preparation of sertraline hydrochloride, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, in its crystalline form II.

The present invention is directed to forms II, III, V, VI, VII, VIII, IX and X of sertraline hydrochloride and novel methods for their preparation. According to the present invention, sertraline hydrochloride polymorph II may be produced by slurrying sertraline hydrochloride polymorph VI in aprotic organic solvent. Sertraline hydrochloride polymorphic form III may be produced by heating sertraline hydrochloride polymorphs V and VI. Sertraline hydrochloride forms V and VI may be produced from either sertraline hydrochloride or sertraline base by crystallization. Sertraline hydrochloride Form VII may be produced by suspending sertraline chloride polymorph V in water, followed by filtration. Sertraline hydrochloride Forms VIII and IX may be produced by suspending sertraline base in water followed by acidification and filtration. Sertraline hydrochloride Form X may be produced by suspending sertraline hydrochloride in benzyl alcohol with heating, followed by filtration.

Provided are processes for the preparation of sertraline and sertraline hydrochloride.

The invention discloses a high-speed countercurrent chromatographic separation method for sertraline-hydrochloride cis-trans isomer. The method includes the specific steps that an organic solvent anda citric acid-sodium hydrogen phosphate buffer solution containing hydroxypropyl-beta-cyclodextrin are mixed according to the volume ratio of 1:(0.5-10) to form a solvent system, standing layering isconducted, an obtained organic phase serves as a stationary phase, and a water phase serves as a mobile phase; separation is conducted with the countercurrent chromatography, and cis-form sertraline hydrochloride and trans-form sertraline hydrochloride are obtained. In the separation and purification process, the condition is mild, the separation process is efficient and convenient and fast, the separation and preparation quantity is large, the separation degree is high, and both the purity of the cis-form sertraline hydrochloride obtained after purification and the purity of the trans-form sertraline hydrochloride obtained after purification are larger than 98%.

This invention relates to crystalline polymorphs of sertraline hydrocloride, i.e. (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, denominated form I, II and V, and methods for their preparation.

The invention discloses a preparation method of chiral sertraline hydrochloride. The method comprises the steps that cis-sertraline hydrochloride and alkali of alkali metal salt containing D-mandelicacid are mixed and stirred in a solvent, after dehydration, inorganic salt is filtered out, a filtrate is cooled and crystallized, and solid-liquid separation is carried out; coarse D-mandelic acidsertraline is recrystallized, and solid-liquid separation is carried out; refined D-mandelic acid sertraline reacts with inorganic alkali in a mixed solvent of water and the organic solvent, and dehydration, crystallization and solid-liquid separation are carried out; a filtrate and hydrogen chloride are mixed and stirred in an organic solvent, after salification is completed, solid-liquid separation, washing and drying are carried to obtain the chiral sertraline hydrochloride. The preparation method of the chiral sertraline hydrochloride has the advantages that the alkali metal salt of the D-mandelic acid is taken as a resolving agent, the yield of cis-(1S,4S)-hydrochloride sertraline is high, the single organic solvent can be adopted in the entire process, the recovery rate of the alkalimetal salt of the D-mandelic acid and solvent is high, the alkali metal salt and the solvent can be recycled, and the preparation method is simple in operation, safe, environmentally friendly and suitable for industrial production.

The invention discloses a preparation method of chiral sertraline hydrochloride. The method comprises the following steps: mixing racemic sertraline and a chiral ionic liquid of D-mandelic acid; slowly stirring at 10-100 DEG C for full reaction; after reaction, adding absolute ethyl alcohol into the reaction mixed liquid for continuously stirring for 1 hour; filtering; hydrolyzing the filter cakes; acidizing by hydrochloric acid to obtain Cis-(1S, 4S)-sertraline hydrochloride; and recovering the filtrate to obtain the chiral ionic liquid which is recycled. According to the invention, the chiral ionic liquid is taken as a solvent and a resolving agent, so that the yield is greater than or equal to 80%, the optical purity is greater than or equal to 98.0%, and the content is greater than or equal to 99.0%. The method is simple and convenient to operate, high in efficiency, less in three wastes and convenient in post-treatment, and the ionic liquid can be repeatedly used, so that the preparation method is an economical and practical green and environment-friendly technology.