Tablet containing paroxetine and preparation method thereof

A paroxetine hydrochloride and tablet technology, which is applied in the field of tablets containing paroxetine and its preparation, can solve the problems of low one-time molding rate, large particle size distribution range, and low single-machine output of dry granulation, and achieve guaranteed Quality and stability, strong wear resistance, good particle fluidity

Active Publication Date: 2012-07-04
江苏万全特创医药生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problems of low primary molding rate of dry granulation, repeated granulation, time-consuming, large pa

Method used

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  • Tablet containing paroxetine and preparation method thereof
  • Tablet containing paroxetine and preparation method thereof
  • Tablet containing paroxetine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018]

[0019] Preparation:

[0020] Mix the prescribed amount of paroxetine hydrochloride and mannitol in equal increments, then mix well with microcrystalline cellulose and low-substituted hydroxypropyl cellulose in equal increments, add purified water to make a soft material, 16 mesh Granulate, ventilate and dry at 50°C until the water content is 2%-3%, then granulate through 24 mesh, weigh to calculate the yield, add magnesium stearate, mix evenly, and tablet.

Embodiment 2

[0022]

[0023] Preparation:

[0024] Mix the prescribed amount of paroxetine and mannitol in equal increments, and then fully mix with microcrystalline cellulose and low-substituted hydroxypropyl cellulose in equal increments, add 10% starch slurry to make a soft material, 16 Mesh granulation, ventilated and dried at 45°C until the water content is 2%-3%, and then granulated through 24 mesh, weighed to calculate the yield, added magnesium stearate, mixed evenly, and pressed into tablets.

Embodiment 3

[0026]

[0027] Preparation:

[0028] Mix the prescribed amount of paroxetine and sucrose in equal increments, then mix well with precrossified starch and low-substituted hydroxypropyl cellulose in equal increments, add povidone aqueous solution to make soft material, 16 mesh Granulate, ventilate and dry at 50°C until the water content is 2%-3%, then granulate through 24 mesh, weigh to calculate the yield, add magnesium stearate, mix evenly, and tablet.

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Abstract

The invention discloses a tablet containing paroxetine and a preparation method thereof. The tablet is composed of paroxetine hydrochloride and auxiliary materials accepted in pharmacy and prepared in a wet granulation process, thereby not affecting tablet manufacturing modes and guaranteeing quality and stability of tablets. The tablet is simple in preparation method, wide in application scope, convenient to transport and store and suitable for scale production. The preparation method is convenient to operate.

Description

technical field [0001] The invention relates to a tablet containing paroxetine and a preparation method thereof. The tablet is prepared by a wet granulation process, which does not affect the preparation form and ensures the quality and stability of the preparation. The preparation method is simple and the operation is convenient , has a wide range of applications, is convenient for transportation and storage, and is suitable for large-scale production. Background technique [0002] According to the classification of biopharmaceuticals, paroxetine belongs to the class of drugs with high solubility and high permeability. Its chemical structure is different from piperidine compounds of tricyclics, tetracyclics and other existing antidepressants, and is suitable for oral administration. [0003] Temperature and humidity have a great influence on paroxetine, and it often appears pink, and its hydrochloride form is relatively stable, but if it encounters a substance with strong ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4525A61K47/36A61K47/38A61P25/24
Inventor 刘延伟任霞
Owner 江苏万全特创医药生物技术有限公司
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