Paroxetine hydrochloride sustained release tablet and preparation method of same

A sustained-release tablet and sustained-release layer technology, which is applied in pharmaceutical formulations, pill delivery, and inorganic non-active ingredients. Increase the side effects and avoid the effect of high blood concentration

Inactive Publication Date: 2017-12-01
北京满格医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process has high requirements on double-layer tableting equipment, which is easy to cause material waste, low product yield, and the preparation process is relatively cumbersome, which increases the preparation cost of the product
[0007] In addition, the commercially available paroxetine hydrochloride ordinary tablets still have unstable release in vivo, and the local drug concentration is relatively high, which may easily cause side effects of local gastrointestinal irritation

Method used

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  • Paroxetine hydrochloride sustained release tablet and preparation method of same
  • Paroxetine hydrochloride sustained release tablet and preparation method of same
  • Paroxetine hydrochloride sustained release tablet and preparation method of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Drug-loaded layer

[0042]

[0043] Preparation process: The fluidized bed bottom spraying process is adopted, and the parameters are set to coat the drug-loaded layer solution. During the coating process, there is adhesion between the pellets, and the coating efficiency is calculated to be 52% after screening to remove the adhesive pellets.

Embodiment 2

[0045] Drug-loaded layer

[0046]

[0047]

[0048] Preparation process: The drug-loaded layer was coated according to the method in Example 1, but the phenomenon of sticking pills still occurred.

Embodiment 3

[0050] Drug-loaded layer

[0051]

[0052] Preparation process: The drug-loaded layer was coated according to the method in Example 1, and no sticky pellets appeared. After sieving, it was found that the coating liquid was not viscous enough, and the coating process did not adhere to the core of the pellets, and it became a fine powder after direct drying , The coating efficiency is 61%.

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PUM

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Abstract

The invention relates to a paroxetine hydrochloride sustained release tablet and belongs to the technical field of pharmacy. According to a technical scheme, the paroxetine hydrochloride sustained release tablet is composed of a sustained release micro-pellet and common excipients. The sustained release micro-pellet is composed of a medicine-carrier layer, a sustained release layer and an enteric layer. The use amount of talcum powder in the sustained release layer is 20-100% of a high-molecular sustained release material in the layer. The use amount of talcum powder in the enteric layer is 50-200% of a high-molecular enteric material in the layer. Through regulation on the use amount of talcum powder, an effect of shading protection on the active component is achieved.

Description

technical field [0001] The invention relates to a paroxetine hydrochloride sustained-release tablet, which belongs to the technical field of pharmacy. Background technique [0002] In modern society, people are under increasing pressure in study, work and family, which leads to more and more patients with depression. For people with depression, medication is essential. [0003] Paroxetine hydrochloride is a selective oral serotonin reuptake inhibitor (SSRI) with a structural formula as shown in the figure below. It is an effective drug for the treatment of major depression and generalized anxiety. This drug can be used not only to treat symptoms such as sleep disturbance, fatigue, lack of pleasure and loss of appetite caused by depression, but also to inhibit the recurrence of symptoms such as panic disorder, depression and obsessive-compulsive disorder. [0004] [0005] Studies have shown that paroxetine hydrochloride is stable under high temperature and high humidity...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/4525A61K47/02A61P25/24A61P25/22
CPCA61K9/0002A61K9/2081A61K9/501A61K9/5078A61K31/4525
Inventor 贾煜娇梁屹汪娟
Owner 北京满格医药科技有限公司
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