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Griseofulvin production strain culture medium

A culture medium, griseofulvin technology, applied in microorganisms, fungi, microorganism-based methods, etc., can solve the problem of high cost, and achieve the effects of reducing raw material costs, saving power, and shortening the cultivation period

Inactive Publication Date: 2018-10-12
CHIFENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Indica rice raw materials are mostly produced in the south, and the cost is relatively high

Method used

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  • Griseofulvin production strain culture medium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: A culture medium for the production of griseofulvin, which is prepared from the following raw materials in parts by weight: 850 parts of water, 52 parts of corn flour, 3.5 parts of potassium dihydrogen phosphate, and 1.5 parts of sodium chloride , 1.2 parts of potassium chloride, 1.2 parts of ammonium sulfate, 1.5 parts of sodium nitrate, 1.5 parts of ferrous sulfate, 4 parts of calcium carbonate.

Embodiment 2

[0013] Example 2: A culture medium for the production of griseofulvin, which is prepared from the following raw materials in parts by weight: 720 parts of water, 35 parts of corn flour, 3 parts of potassium dihydrogen phosphate, and 1 part of sodium chloride , 1.5 parts of potassium chloride, 1.5 parts of ammonium sulfate, 2 parts of sodium nitrate, 2 parts of ferrous sulfate, 3 parts of calcium carbonate.

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PUM

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Abstract

The invention discloses a griseofulvin production strain culture medium. The griseofulvin production strain medium is prepared from the following raw materials in parts by weight: 700-900 parts of water, 35-70 parts of corn flour, 3-4 parts of potassium dihydrogen phosphate, 1-2 parts of sodium chloride, 1-1.5 parts of potassium chloride, 1-1.5 parts of ammonium sulfate, 1-2 parts of sodium nitrate, 1-2 parts of ferrous sulfate and 3-5 parts of calcium carbonate. By using the griseofulvin production strain culture medium for producing a griseofulvin production strain, the quality is stable, the reproductivity is high, the cost is low, and economic benefits are significant.

Description

Technical field [0001] The invention belongs to the technical field of strain culture medium, in particular to a strain culture medium for griseofulvin production. Background technique [0002] Griseofulvin (griseofulvin) is an aromatic derivative antibiotic. It is an antifungal antibiotic. It is widely used clinically to treat infections caused by filamentous fungi in the superficial layer of the skin, and has a significant effect. It is also used to fight plant fungal diseases in agriculture. [0003] At present, the strains used in the domestic fermentation and production of griseofulvin are the wild-type Penicillium patulum 4541 strain, which is self-selected in my country, and the descendant N15-3-40 of the D-756 strain derived by artificial mutagenesis. Since the production of griseofulvin by fermentation, indica rice has been used as the main carbon source material for the culture medium. Indica rice raw materials are mostly produced in the south, and the cost is relativel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/14C12R1/83
CPCC12N1/14
Inventor 胡建华张国银付桂杰杨春波刘俊芳李东旭崔广义贾广臣宫海燕刘春红董仕杰
Owner CHIFENG PHARMA CO LTD
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