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Method for removing griseofulvin in biological medicine waste residues

A technology of griseofulvin and biomedicine, which is applied in the field of removing griseofulvin from biomedical waste residues, can solve problems such as no oxidation method research reports, and achieve good environmental protection application prospects, high removal rate, and good application prospects Effect

Active Publication Date: 2016-11-16
SHANGHAI RES INST OF CHEM IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are no more detailed research reports on oxidation methods in the literature

Method used

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  • Method for removing griseofulvin in biological medicine waste residues

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Griseofulvin content is 2360ppm. Griseofulvin waste residue 20g adds 180g water, forms the slurry that solid content is 10%; Carry out steam sterilization 20 minutes; Add oxidant potassium persulfate 20g, catalyst FeSO 4 ·7H 2 O2g, cocatalyst phosphoric acid 10g, reacted 3 hours under 90 ℃, normal pressure condition; Through separation and drying again, obtain the product 24.62g that solid content is 80%; After testing griseofulvin residue is 20ppm, and degradation rate reaches More than 99%.

Embodiment 2

[0031] Griseofulvin content is 2100ppm. Griseofulvin waste residue 200g adds 600g water, forms the slurry that solid content is 25%; Carry out steam sterilization 30 minutes; Add oxidant potassium permanganate 50g, catalyst CoCl 2 2.5g, cocatalyst oxalic acid 10g, reacted at 10°C and normal pressure for 8 hours; then separated and dried to obtain 259g of product with a solid content of 75%; the residual amount of griseofulvin was 20.7ppm after detection, and the degradation rate Reach more than 99%.

Embodiment 3

[0033] Griseofulvin content is 3000ppm. Griseofulvin waste residue 1500g adds 3500g water, forms the slurry that solid content is 30%; Carry out steam sterilization 60 minutes; Add oxidizing agent 30% hydrogen peroxide 600g in the slurry afterwards, catalyst FeCl 2 180g, co-catalyst hydrochloric acid 170g, reacted for 1 hour under the conditions of 180°C and 0.5MPa pressure; then separated and dried to obtain 1930g of a product with a solid content of 70%; the residual amount of griseofulvin was 16.9ppm after detection, and the degradation The rate reaches more than 99%.

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Abstract

The invention relates to a method for removing griseofulvin in biological medicine waste residues. The method for removing the griseofulvin in the biological medicine waste residues specifically comprises the following steps of (1) a pretreatment process including the sub-steps that (1-1) the to-be-treated biological medicine waste residues containing the griseofulvin is mixed with water, and waste residue slurry with the solid content being 5%-45% is prepared through slurry mixing and dispersing, and (1-2) the waste residue slurry is sterilized; and (2) a catalytic and oxidative degradation process, specifically, catalytic and oxidative degradation is conducted by adding an oxidative and catalytic agent into the sterilized waste residue slurry, and then filtering separation and drying are conducted. Compared with the prior art, a wet catalytic and oxidative treatment integrated technique is used for removing the griseofulvin left in the waste residues, the removal rate is high, secondary pollutants are avoided, and harmless treatment is achieved; the concentration of the griseofulvin left in the waste residues can be rapidly decreased to 0-50 ppm from the original 1000-5000 ppm, the mass reduction rate of the biological medicine waste residues is smaller than 10%, and the method has extremely good application prospects.

Description

technical field [0001] The invention belongs to the technical field of medicine and environmental protection, and relates to a method for removing griseofulvin in biomedical waste residues. Background technique [0002] my country is the world's largest producer and exporter of antibiotic raw materials, with total output accounting for 70% of global production. Hundreds of tons of biomedical waste containing residual antibiotics are produced every year. [0003] Biomedical waste residues contain residual antibiotics. If they enter the natural environment without treatment, antibiotics will form a high-concentration area in surface water, rivers and other water bodies, resulting in the increase and spread of antibiotic resistance of pathogenic bacteria in the environment. Human public health poses a threat. If untreated medical waste residues are directly used as breeding feed, the residual antibiotics will enter the food chain, which will seriously affect food safety. [...

Claims

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Application Information

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IPC IPC(8): A62D3/38A62D101/47
CPCA62D3/38A62D2101/47
Inventor 卢啸旸曹卫宇邹晓岱何佩华陈国华张伟罗勇田智宇
Owner SHANGHAI RES INST OF CHEM IND
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