Preparation method of griseofulvin
A technology of griseofulvin and acetone, which is applied in the field of griseofulvin preparation, can solve the problems of power, energy waste, increased production cost, and large loss of solvent, so as to save energy, reduce the number of crystallization times, and reduce production costs Effect
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Embodiment 1
[0013] Example 1 A preparation method of griseofulvin, comprising the following steps:
[0014] A. Heating the griseofulvin fermentation broth to 80°C, adding calcium oxide to adjust the pH to 5.5, separating solid-liquid from the plate and frame, adding calcium oxide to the filter cake for granulation, and acetone extraction to obtain griseofulvin acetone extract;
[0015] B, the griseofulvin acetone extract is decolorized by the activated carbon column to obtain the griseofulvin acetone decolorization solution, and the decolorized solution enters the concentration tank, and decompresses by the way of steam circulating heating in the jacket and vacuuming of the tank to reduce the boiling point of acetone Concentrated, the concentration temperature is controlled at 27 o C, the vacuum degree is controlled at -0.09MPa, after concentration, the acetone evaporates rapidly, is cooled and recovered, recycled, and the crystals are naturally separated out. Under vacuum conditions, ...
Embodiment 2
[0018] Example 2 A preparation method of griseofulvin, comprising the following steps:
[0019] A. Heating the griseofulvin fermentation broth to 100°C, adding calcium oxide to adjust the pH to 6, separating solid-liquid from the plate and frame, adding calcium oxide to the filter cake for granulation, and acetone extraction to obtain griseofulvin acetone extract;
[0020] B, the griseofulvin acetone extract is decolorized by the activated carbon column to obtain the griseofulvin acetone decolorization solution, and the decolorized solution enters the concentration tank, and decompresses by the way of steam circulating heating in the jacket and vacuuming of the tank to reduce the boiling point of acetone Concentrated, the concentration temperature is controlled at 24 o C, the vacuum degree is controlled at -0.07MPa, after concentration, the acetone evaporates rapidly, is cooled and recovered, recycled, and the crystals are naturally precipitated. When the acetone is not comp...
Embodiment 3
[0023] Example 3 A preparation method of griseofulvin, comprising the following steps:
[0024] A. The griseofulvin fermentation broth is heated to 90°C, calcium oxide is added to adjust the pH to 6.5, solid-liquid separation of the plate and frame, granulation of the filter cake with calcium oxide, and acetone extraction to obtain the griseofulvin acetone extract;
[0025] B, the griseofulvin acetone extract is decolorized by the activated carbon column to obtain the griseofulvin acetone decolorization solution, and the decolorized solution enters the concentration tank, and decompresses by the way of steam circulating heating in the jacket and vacuuming of the tank to reduce the boiling point of acetone Concentrated, the concentration temperature is controlled at 30 o C, the vacuum degree is controlled at -0.08MPa, after concentration, the acetone evaporates rapidly, is cooled and recovered, recycled, and the crystals are naturally separated out. Under vacuum conditi...
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