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Preparation method of hydroxyapatite/polylactic acid composite coating on surface of medical magnesium alloy

A technology of hydroxyapatite and composite coating, which is applied to the device for coating liquid on the surface, metal material coating process, coating and other directions to achieve the effect of reducing corrosion rate, improving biocompatibility and avoiding local infection

Inactive Publication Date: 2014-07-23
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] The purpose of the present invention is exactly to provide a kind of preparation method of hydroxyapatite / polylactic acid composite coating on the surface of biomedical magnesium alloy in order to overcome the deficiency of single coating, the composite coating that this invention obtains makes magnesium alloy corrosion resistance and Significantly improved biocompatibility

Method used

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  • Preparation method of hydroxyapatite/polylactic acid composite coating on surface of medical magnesium alloy

Examples

Experimental program
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Effect test

Embodiment 1

[0032] (1) Simple pretreatment of the substrate: Cut the ZK60 magnesium alloy into moderate-sized samples with a wire cutting machine, and then polish them with 800# and 2000# alumina water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, and then use deionized water Ultrasonic cleaning with anhydrous ethanol for 10 minutes, and drying at room temperature for later use;

[0033] (2) Acid etching pretreatment: the magnesium alloy substrate obtained by simple pretreatment was etched in 90% (v%) phosphoric acid solution at 55°C for 30s, then placed in 1M NaOH solution for 90s, and then placed in Rinse in distilled water for about 30 seconds, and dry for later use.

[0034] (3) Configuration of conversion solution: The conversion solution used was prepared from sodium dihydrogen phosphate dihydrate and calcium nitrate tetrahydrate, and a low-concentration conversion solution (as shown in Table 1) was prepared, wherein the solvent was deionized w...

Embodiment 2

[0041] (1) Simple pretreatment of the substrate: Cut the ZK60 magnesium alloy into moderate-sized samples with a wire cutting machine, and then polish them with 800# and 2000# alumina water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, and then use deionized water Ultrasonic cleaning with anhydrous ethanol for 10 minutes, and drying at room temperature for later use;

[0042] (2) Acid etching pretreatment: the magnesium alloy substrate obtained by simple pretreatment was etched in 90% (v%) phosphoric acid solution at 55°C for 40 seconds, then placed in 1M NaOH solution for neutralization treatment for 2 minutes, and then Rinse in distilled water for about 30 seconds, and dry for later use.

[0043] (3) Configuration of conversion solution: The conversion solution used was prepared from sodium dihydrogen phosphate dihydrate and calcium nitrate tetrahydrate, and a low-concentration conversion solution (as shown in Table 1) was prepared, whe...

Embodiment 3

[0050] (1) Simple pretreatment of the substrate: Cut the ZK60 magnesium alloy into moderate-sized samples with a wire cutting machine, and then polish them with 800# and 2000# alumina water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, and then use deionized water Ultrasonic cleaning with anhydrous ethanol for 20 minutes, and drying at room temperature for later use;

[0051] (2) Acid etching pretreatment: the magnesium alloy substrate obtained by simple pretreatment was etched in 90% (v%) phosphoric acid solution at 55°C for 30s, then placed in 1M NaOH solution for 90s, and then placed in Rinse in distilled water for about 30 seconds, and dry for later use.

[0052] (3) Configuration of conversion solution: The conversion solution used was prepared from sodium dihydrogen phosphate dihydrate and calcium nitrate tetrahydrate, and a high-concentration conversion solution (as shown in Table 1) was prepared, wherein the solvent was deionized ...

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Abstract

The invention relates to a preparation method of a hydroxyapatite / polylactic acid composite coating on the surface of medical magnesium alloy, which comprises the following steps of polishing a magnesium alloy basal body to remove an oxidation layer on the surface; carrying out acid etching pretreatment and neutralizing treatment on the magnesium alloy basal body; preparing transfer solution from sodium dihydrogen phosphate dihydrate and calcium nitrate terahydrate; preparing a biomimetic calcium-phosphate coating; dissolving polylactic acid in a chloroform solvent to prepare polylactic acid solution; immersing the prepared magnesium alloy / hydroxyapatite composite material in the polylactic acid solution, and coating the polylactic acid coating on the surface of the magnesium alloy / hydroxyapatite composite material by adopting the solution dip-coating method; and putting the magnesium alloy material for 2-3 days till chloroform in the polylactic acid solution is completely volatilized, thereby obtaining the composite material of which the surface of magnesium alloy is wrapped with the hydroxyapatite / polylactic acid composite coating. Compared with the prior art, the preparation method of the hydroxyapatite / polylactic acid composite coating on the surface of medical magnesium alloy overcomes the disadvantages of the single coating, and therefore, the corrosion resistance and the biocompatibility of magnesium alloy are obviously increased.

Description

technical field [0001] The invention relates to a preparation method of a composite material, in particular to a preparation method of a hydroxyapatite / polylactic acid composite coating on the surface of a medical magnesium alloy. Background technique [0002] Bone defect repair and reconstruction has always been a challenging topic in the field of orthopedics, and autologous bone grafting is used clinically to repair bone defects. However, there are disadvantages such as insufficient donors, secondary injuries to patients, and complications at the donor site. The principle of tissue engineering is to use biological materials as carriers to carry different types of cells into the host, and finally form tissues with normal structure and function. This technique for repairing bone defects has become a research hotspot at present. How to develop porous scaffold materials with excellent performance is an urgent problem to be solved in the field of bone tissue engineering. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/32A61L27/04C23C22/07B05D7/24B05D3/10
Inventor 陆伟黄平凌敏贾敏
Owner TONGJI UNIV
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