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Preparation method of graphene/hydroxyapatite composite ceramic material

A technology of hydroxyapatite and composite ceramics, used in dental preparations, pharmaceutical formulations, dental prostheses, etc., can solve the problem of uneven distribution of graphene and hydroxyapatite, damage to the matrix and reinforcement phase, poor toughness of composite materials, etc. problems, to facilitate large-scale production, improve the brittleness problem, and achieve the effect of short production cycle

Inactive Publication Date: 2017-07-28
SHANDONG NORMAL UNIV
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Problems solved by technology

During the preparation process, the matrix and the reinforcement phase will be damaged to a certain extent, accompanied by stress, which will lead to uneven distribution of graphene and hydroxyapatite in the obtained product, and its performance will be greatly reduced.
[0005] Therefore, in the prior art, there is still no effective solution to the problems of uniform distribution of graphene and hydroxyapatite, low bonding strength, poor toughness and low hardness of composite materials.

Method used

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  • Preparation method of graphene/hydroxyapatite composite ceramic material
  • Preparation method of graphene/hydroxyapatite composite ceramic material
  • Preparation method of graphene/hydroxyapatite composite ceramic material

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preparation example Construction

[0032] As introduced in the background technology, there are some deficiencies in the preparation method of graphene / hydroxyapatite composite ceramic material in the prior art. In order to solve the above problems, the present invention proposes a graphene / hydroxyapatite composite ceramic material. The preparation method comprises the following steps:

[0033] The first step: respectively prepare Ca(NO 3 ) 2 4H 2O solution and (NH 4 ) 2 HPO 4 solution, the Ca(NO 3 ) 2 4H 2 The pH of the O solution was adjusted with ammonia water; the Ca(NO 3 ) 2 4H 2 O solution and (NH 4 ) 2 HPO 4 The solution is mixed and stirred well.

[0034] In some preferred technical solutions of the present invention, configured Ca(NO 3 ) 2 4H 2 O and (NH 4 ) 2 HPO 4 The substance concentration of the solution is 0.4-0.6mol / L, and the substance quantity ratio of calcium and phosphorus contained in the solution is 1:1.67. The concentration of this substance is used to make graphene o...

Embodiment 1

[0050] A preparation method of graphene / hydroxyapatite composite ceramic material, comprising the following steps:

[0051] (1) Preparation of graphene oxide

[0052] Pour 80ml of concentrated sulfuric acid, 9g of potassium permanganate and 2g of graphite powder refrigerated for 12 hours into the reaction kettle, let it stand at a low temperature at 0°C, and then put it into an oven. Pour the product into 320ml of deionized water for dilution, and add hydrogen peroxide and stir until the mixture turns yellowish brown or golden yellow. After standing still, the precipitate was washed by centrifugation and placed in a vacuum oven to dry to obtain graphene oxide (GO).

[0053] (2) Preparation of graphene / hydroxyapatite

[0054] Weigh 29.52gCa(NO 3 ) 2 4H 2 O and 16.51g (NH 4 ) 2 HPO 4 Dissolve them in 250ml of deionized water to form a 0.5mol / L solution. Place in a constant temperature water bath and heat to constant temperature and adjust the pH value of calcium phospha...

Embodiment 2

[0060] A preparation method of graphene / hydroxyapatite composite ceramic material, comprising the following steps:

[0061] (1) Preparation of graphene oxide

[0062] Pour 80ml of concentrated sulfuric acid, 9g of potassium permanganate and 2g of graphite powder refrigerated for 12 hours into the reaction kettle, let it stand at a low temperature at 0°C, and then put it into an oven. Pour the product into 320ml of deionized water for dilution, and add hydrogen peroxide and stir until the mixture turns yellowish brown or golden yellow. After standing still, the precipitate was washed by centrifugation and placed in a vacuum oven to dry to obtain graphene oxide (GO).

[0063] (2) Preparation of graphene / hydroxyapatite

[0064] Weigh 59.04gCa(NO 3 ) 2 4H 2 O and 33.02g (NH 4 ) 2 HPO 4 Dissolve them in 250ml of deionized water to form a 0.5mol / L solution. Place in a constant temperature water bath and heat to constant temperature and adjust the pH value of calcium phospha...

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Abstract

The invention discloses a preparation method of a graphene / hydroxyapatite composite ceramic material. To be specific, graphene oxide, used as a reinforcement phase, is added to hydroxyapatite which is prepared by a chemical precipitation method and then is subjected to microwave sintering to obtain the graphene / hydroxyapatite composite ceramic material. The preparation method mainly solves the problems that conventional hydroxyapatite material preparation process is complex, low in production efficiency, high in production cost and incapable of meeting gradually improved living requirements of people and the like. The preparation method has the advantages of short production cycle, simple technique, no waste of raw materials, and easiness in building a full-automatic production line. By the preparation method, the graphene / hydroxyapatite composite ceramic material with good wear resistance, zero toxic and side effect, high toughness and good biocompatibility is obtained.

Description

technical field [0001] The invention relates to a preparation method of a graphene / hydroxyapatite composite ceramic material, belonging to the technical field of biomedical materials. Background technique [0002] Hydroxyapatite ceramic is the crystalline phase of calcium hydrogen phosphate, its molecular formula is Ca 10 (PO 4 ) 6 (OH) 2 , referred to as HA, has hexagonal crystal symmetry. HA is the main inorganic component of human and animal bones, has good biocompatibility and biological activity, and can be closely integrated with bones in the body. Under the action of body fluids, it will be completely degraded, and calcium and phosphorus will be released, which will be absorbed and utilized by human tissues to grow new tissues, thereby producing bone conduction. In bone, hydroxyphosphate accounts for about 60%, and is an irregular needle-like crystal with a length of 20-40nm and a thickness of 1.5-3nm, and collagen fibers are regularly arranged around it. Hydrox...

Claims

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Application Information

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IPC IPC(8): C04B35/447C04B35/622C04B35/64C04B35/626A61L27/12A61L27/08A61L27/50A61K6/033A61K6/027A61K6/838
CPCA61L27/08A61L27/12A61L27/50A61L2430/02A61K6/831A61K6/838C04B35/447C04B35/622C04B35/62625C04B35/64C04B2235/425C04B2235/661C04B2235/667
Inventor 于雅楠高嵩
Owner SHANDONG NORMAL UNIV
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