Method for preparing composite bone repair stent material containing chitosan and hydroxylapatite

A technology of hydroxyapatite and scaffold materials, which is applied in the fields of scaffolds, medical science, prostheses, etc., can solve the problems of uneven distribution of scaffolds, affecting the growth of osteoblasts, and the decline of mechanical properties of scaffolds, achieving strength adjustability, Excellent mechanical strength, the effect of strength

Inactive Publication Date: 2009-03-04
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In the past, the preparation of chitosan and hydroxyapatite composite bone repair scaffold materials mainly has the following two types of methods, one is to directly mix chitosan and hydroxyapatite, resulting in the agglomeration of hydroxyapatite in the chitosan matrix , and the uneven distribution in the final scaffold will affect the growth of osteoblasts; the mechanical properties of the scaffold will decrease
The other is the in situ compounding of hydrox

Method used

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  • Method for preparing composite bone repair stent material containing chitosan and hydroxylapatite
  • Method for preparing composite bone repair stent material containing chitosan and hydroxylapatite

Examples

Experimental program
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Effect test

Embodiment 1

[0021] 1) Weigh CaCl according to the stoichiometric ratio 2 and KH 2 PO 4 Add it to 250ml of acetic acid solution with a volume fraction of 2%, and stir evenly to obtain a hydroxyapatite precursor solution;

[0022] 2) Add 10g chitosan to the hydroxyapatite precursor solution to make a chitosan and hydroxyapatite composite solution with a mass concentration of 4%, and the mass ratio of chitosan to hydroxyapatite is 100: 5. Stir vigorously to form a uniform mixed solution of chitosan and hydroxyapatite, and let it stand for defoaming;

[0023] 3) Take a small amount of mixed solution of chitosan and hydroxyapatite and evenly coat the surface of the mold, place the mold in 5% NaOH coagulating solution at room temperature to solidify to form a film, then mix chitosan and hydroxyl The mixed solution of apatite is injected into the mold, and then the mold is put into a NaOH coagulation solution with a mass fraction of 5%, solidified for 8 hours, and demolded to obtain a gel of ...

Embodiment 2

[0030] 1) Weigh Ca(NO 3 ) 2 and NaH 2 PO 4 Add it to 250ml of acetic acid solution with a volume fraction of 2%, and stir evenly to obtain a hydroxyapatite precursor solution;

[0031] 2) Add 10g chitosan to the hydroxyapatite precursor solution to make a chitosan and hydroxyapatite composite solution with a mass concentration of 4%, and the mass ratio of chitosan to hydroxyapatite is 100: 10. Stir vigorously to form a uniform mixed solution of chitosan and hydroxyapatite, and let it stand for defoaming;

[0032] 3) Take a small amount of mixed solution of chitosan and hydroxyapatite and evenly coat the surface of the mold, place the mold in 5% NaOH coagulating solution at room temperature to solidify to form a film, then mix chitosan and hydroxyl The mixed solution of apatite is injected into the mold, and then the mold is put into a NaOH coagulation solution with a mass fraction of 5%, solidified for 4 hours, and demolded to obtain a gel of chitosan and hydroxyapatite; ...

Embodiment 3

[0039] 1) Weigh CaCl according to the stoichiometric ratio 2 and K 2 HPO 4 Add it to 250ml of acetic acid solution with a volume fraction of 2%, and stir evenly to obtain a hydroxyapatite precursor solution;

[0040] 2) Add 10g chitosan to the hydroxyapatite precursor solution to make a chitosan and hydroxyapatite composite solution with a mass concentration of 4%, and the mass ratio of chitosan to hydroxyapatite is 100: 15. Stir vigorously to form a uniform mixed solution of chitosan and hydroxyapatite, and let it stand for defoaming;

[0041] 3) Take a small amount of mixed solution of chitosan and hydroxyapatite and evenly coat the surface of the mold, place the mold in 5% NaOH coagulating solution at room temperature to solidify to form a film, then mix chitosan and hydroxyl The mixed solution of apatite is injected into the mold, and then the mold is put into a NaOH coagulation solution with a mass fraction of 5%, solidified for 8 hours, and demolded to obtain a gel of...

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Abstract

The invention discloses a method for preparing chitosan and hydroxyapatite composite bone support materials, which comprises the following steps: a precursor solvent of hydroxyapatite is prepared, and mixed solvents of chitosan and hydroxyapatite are prepared and placed still for defoaming; mixed solvents are evenly applied on the surface of a mould, and placed in alkalescence concreting liquid at room temperature to be concreted into a membrane; then the mixed solvents are injected into the mould, and the mould is put into the alkalescence concreting liquid again; after concretion and demoulding, gel compounded by the chitosan and the hydroxyapatite is obtained, and distilled water is used for washing the gel to neutrality; and only predry, re-freezing and desiccation in vacuum are needed. The support materials have the advantages of three-dimension sequence, good mechanical properties and high porosity, thus promoting the absorption and the growth of cells. The hydroxyapatite granules are evenly distributed in the chitosan kinetosome and can keep the continuous, stable and adagio release of calcium ions and phosphor ions in hydroxyapatite from chitosan kinetosome during the bone repairing process, thus avoiding burst release.

Description

technical field [0001] The invention relates to a bone repair scaffold material, especially a preparation method of a composite bone repair scaffold material composed of chitosan and hydroxyapatite. Background technique [0002] Chitosan (Chitosan, CS) is a natural biodegradable polysaccharide, and its degradation product is weakly alkaline glucosamine, which is non-toxic and harmless to the human body and tissues. In addition to its excellent biocompatibility, it also has natural drug activity, anti-tumor activity, anti-inflammatory effect, and accelerates wound healing. [0003] The chemical structure of hydroxyapatite (Hydroxyapatite, HA) is (Ca 10 (OH) 2 (PO 4 ) 6 ), is the main component of human natural bone (containing 60-70%), has excellent biological activity and guides the growth of bone tissue. HA implants have been shown to induce the growth of surrounding bone tissue and form a strong chemical bond with the host bone. [0004] Adding hydroxyapatite into ch...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61F2/82
Inventor 胡巧玲李愔喆王幽香
Owner ZHEJIANG UNIV
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