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Calcium phosphate nano-structures and preparation method thereof

A nanostructure, calcium phosphate technology, applied in the field of preparation of calcium phosphate nanomaterials, can solve problems such as environmental pollution and increase production costs, and achieve the effects of environmental friendliness, convenient operation and good biodegradation performance.

Active Publication Date: 2013-01-30
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The surfactant added by this method needs to be cleaned up in the subsequent treatment, thus increasing the production cost and causing environmental pollution
There are few reports in the literature on the synthesis of calcium phosphate biomaterials using organic biological phosphorus sources

Method used

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  • Calcium phosphate nano-structures and preparation method thereof
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  • Calcium phosphate nano-structures and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] At room temperature, 0.111 g of CaCl 2 Dissolve in 30 ml of deionized water to form liquid A, and dissolve 0.122 g of trisodium fructose diphosphate in 10 ml of deionized water to form liquid B. After adjusting liquid A with 1 mol / L sodium hydroxide to make its pH equal to 10, add liquid B dropwise, and use magnetic stirring during this process to keep the pH at around 10. After the dropwise addition was completed, the mixed clear solution was transferred into a microwave reactor (capacity 60 ml) and reacted at 100 °C for 10 min. After the reaction system was naturally cooled to room temperature, the product was taken out and centrifuged. The separated product was washed three times with deionized water, once with absolute ethanol, and dried in air at 60°C to obtain Figure 4 For the shown calcium phosphate nanosphere powder, the average diameter of the calcium phosphate nanosphere is 300 nanometers.

Embodiment 2

[0051] At room temperature, 0.111 g of CaCl 2 Dissolve in 30 ml of deionized water to form liquid A, and dissolve 0.122 g of trisodium fructose diphosphate in 10 ml of deionized water to form liquid B. After adjusting liquid A with 1 mol / L sodium hydroxide to make its pH equal to 10, add liquid B dropwise, and use magnetic stirring during this process to keep the pH at around 10. After the dropwise addition was completed, the mixed clear solution was transferred to a microwave reactor (capacity 60 ml) and reacted at 120 °C for 10 min. After the reaction system was naturally cooled to room temperature, the product was taken out and centrifuged. The separated product was washed three times with deionized water, once with absolute ethanol, and dried in air at 60°C to obtain Figure 5 For the calcium phosphate nanosphere powder shown, the surface of the calcium phosphate nanosphere is smooth and contains a porous structure, and the diameter of the pores is below 40 nanometers. s...

Embodiment 3

[0054] At room temperature, 0.111 g of CaCl 2 Dissolve in 30 ml of deionized water to form liquid A, and dissolve 0.122 g of trisodium fructose diphosphate in 10 ml of deionized water to form liquid B. After adjusting liquid A with 1 mol / L sodium hydroxide to make its pH equal to 10, add liquid B dropwise, and use magnetic stirring during this process to keep the pH at around 10. After the dropwise addition was completed, the mixed clear solution was transferred into a microwave reactor (capacity 60 ml) and reacted at 120 °C for 30 min. After the reaction system was naturally cooled to room temperature, the product was taken out and centrifuged. The separated product was washed three times with deionized water, once with absolute ethanol, and dried in air at 60°C to obtain Figure 8 For the calcium phosphate nanosphere powder shown, the average diameter of the calcium phosphate nanosphere is 500 nanometers, and the surface is relatively rough. see figure 2 It can be seen t...

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Abstract

The invention relates to calcium phosphate nano-structures and a preparation method thereof. According to the method, water-soluble calcium salt serving as a calcium source and phosphorous biomolecules serving as as a phosphor source are prepared into a calcium phosphate nano-structure powder through a microwave assisted hydrothermal reaction, wherein the phosphorous biomolecules are phosphofructose or fructose diphosphate. The three different nanostructures, namely amorphous calcium phosphate porous nano-spheres, hydroxyapatite nano-rods and amorphous calcium phosphate / hydroxyapatite composite nano-spheres, prepared by the preparation method can be widely applied to biomedicine, tissue engineering and other fields.

Description

technical field [0001] The invention relates to a preparation method and application of a calcium phosphate nanometer material. It specifically relates to a preparation method of using fructose phosphate or fructose phosphate as a phosphorus source to synthesize amorphous calcium phosphate nanospheres, hydroxyapatite nanorods, and amorphous calcium phosphate / hydroxyapatite composite nanospheres, which belongs to the preparation of biological materials and application areas. Background technique [0002] Calcium phosphate is the most important inorganic component of human bones and teeth. Synthetic calcium phosphate has a similar composition and structure to biological calcium phosphate, so it has good biological activity, biocompatibility and biodegradability, and is widely used It is used in biomedical fields such as bone substitute materials, drug delivery carriers, and gene transfection. [0003] As the initial phase of calcium phosphate deposited in aqueous solution, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y30/00
Inventor 朱英杰漆超陈峰
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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