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Polyvinyl alcohol/sodium alginate/hydroxyapatite composite fiber membrane as well as preparation method and application of polyvinyl alcohol/sodium alginate/hydroxyapatite composite fiber membrane

A hydroxyapatite and composite fiber membrane technology, which is used in spinning solution preparation, medical science, non-woven fabrics, etc. Limestone nanoparticles are easy to agglomerate and other problems to achieve the effect of improving the repair effect

Active Publication Date: 2017-05-31
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problem that the comprehensive performance of the existing composite fiber film dressing is not excellent enough, and the hydroxyapatite nanoparticles of the spinning raw material are easily agglomerated and easily dispersed unevenly, and provide a polyvinyl alcohol / sodium alginate / hydroxyphosphorus Limestone composite fiber membrane and preparation method thereof

Method used

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  • Polyvinyl alcohol/sodium alginate/hydroxyapatite composite fiber membrane as well as preparation method and application of polyvinyl alcohol/sodium alginate/hydroxyapatite composite fiber membrane
  • Polyvinyl alcohol/sodium alginate/hydroxyapatite composite fiber membrane as well as preparation method and application of polyvinyl alcohol/sodium alginate/hydroxyapatite composite fiber membrane
  • Polyvinyl alcohol/sodium alginate/hydroxyapatite composite fiber membrane as well as preparation method and application of polyvinyl alcohol/sodium alginate/hydroxyapatite composite fiber membrane

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preparation example Construction

[0027] The invention provides a polyvinyl alcohol / sodium alginate / hydroxyapatite composite fiber membrane and a preparation method thereof, specifically as follows:

[0028] First, prepare a diammonium hydrogen phosphate solution with a concentration of 0.001-0.1mol / L and a calcium nitrate solution with a concentration of 0.00668-0.167mol / L, and quickly pour the diammonium hydrogen phosphate aqueous solution into the calcium nitrate aqueous solution according to the molar ratio of Ca / P=1.67 , adding ammonia water dropwise to the mixed solution to adjust the pH of the solution to 9-10, stirring evenly and then reacting at 80°C, centrifuging and washing with water several times to obtain a white precipitate of hydroxyapatite. Disperse the white precipitate of hydroxyapatite in deionized water, then add sodium alginate to ultrasonically mix and disperse to obtain a suspension of hydroxyapatite stabilized by sodium alginate, wherein the concentration of sodium alginate is 0.04-0.15...

Embodiment 1

[0032]1) First, prepare an aqueous solution of calcium nitrate with a concentration of 0.0334mol / L and an aqueous solution of diammonium hydrogen phosphate with a concentration of 0.02mol / L, respectively. According to the molar ratio of Ca / P=1.67, quickly pour 20mL diammonium hydrogen phosphate aqueous solution into 20mL calcium nitrate aqueous solution, add ammonia water dropwise to the mixed solution, control the pH of the solution to 9-10, stir and mix evenly. After maintaining the reaction temperature at 80° C. for 1 h, centrifugation was repeated three times with deionized water to obtain a white precipitate. The white precipitate was redispersed in 40 mL of deionized water to obtain a hydroxyapatite dispersion with a concentration of 1.67 mg / mL, and 20 mL of this dispersion was taken for use. Take 10mL of deionized water and 0.1g of sodium alginate to prepare a sodium alginate solution with a mass fraction of 1%, add 0.08mL of sodium alginate solution to the above 20mL d...

Embodiment 2

[0039] 1) First, prepare an aqueous solution of calcium nitrate with a concentration of 0.0334mol / L and an aqueous solution of diammonium hydrogen phosphate with a concentration of 0.02mol / L, respectively. According to the molar ratio of Ca / P=1.67, quickly pour 20mL diammonium hydrogen phosphate aqueous solution into 20mL calcium nitrate aqueous solution, add ammonia water dropwise to the mixed solution, control the pH of the solution to 9-10, stir and mix evenly. After maintaining the reaction temperature at 80° C. for 1 h, centrifugation was repeated three times with deionized water to obtain a white precipitate. The white precipitate was redispersed in 40 mL of deionized water to obtain a hydroxyapatite dispersion with a concentration of 1.67 mg / mL, and 20 mL of this dispersion was taken for use. Take 10mL of deionized water and 0.1g of sodium alginate to prepare a sodium alginate solution with a mass fraction of 1%, add 0.08mL of sodium alginate solution to the above 20mL ...

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Abstract

The invention relates to a polyvinyl alcohol / sodium alginate / hydroxyapatite composite fiber membrane as well as a preparation method and application of the polyvinyl alcohol / sodium alginate / hydroxyapatite composite fiber membrane. The preparation method of the composite fiber membrane comprises the following steps: firstly, taking diammonium phosphate and calcium nitrate to react to prepare hydroxyapatite; carrying out ultrasonic dispersion on the hydroxyapatite and sodium alginate to form a stable hydroxyapatite suspension solution; secondly, preparing a sodium alginate solution with the mass percent of 2 percent of a polyvinyl alcohol solution with the mass percent of 18 percent by adopting the suspension solution; finally, uniformly mixing the two types of solutions according to a ratio and carrying out electrostatic spinning. According to the preparation method of the composite fiber membrane, the hydroxyapatite is stably and uniformly dispersed into water by combining the sodium alginate with an ultrasonic method under the condition that other substances are not introduced, and the problem that the hydroxyapatite is easy to agglomerate is solved; the biocompatibility of a natural high polymer and a synthesized high polymer and the bioactivity of hydroxyapatite nanoparticles are combined by adopting the electrostatic spinning to successfully prepare the composite fiber membrane capable of being used as repairing dressing of soft tissue injuries.

Description

technical field [0001] The invention relates to the technical field of electrospinning, in particular to a polyvinyl alcohol / sodium alginate / hydroxyapatite composite fiber membrane and a preparation method and application thereof. Background technique [0002] Soft tissue injury is a very common lesion nowadays. The soft tissue that people often say refers to the skin, subcutaneous tissue, muscles, tendons, ligaments, joint capsules, synovial bursa, nerves, blood vessels, etc. of the human body. Taking the skin as an example, it can protect various tissues and organs in the body from external mechanical and pathogenic invasion, and skin damage and defect will lead to a series of physiological and pathological problems. For large-area skin defects, in addition to autologous skin graft repair, artificial medical dressings can also protect damaged skin, provide a good physiological repair environment for wound healing, and there is no problem of limited autologous skin sources...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/18A61L15/44D04H1/728D04H1/4382D01D1/02
CPCA61L15/18A61L15/24A61L15/28A61L15/44D01D1/02D04H1/728C08L29/04A61L2300/414A61L2300/406D04H1/43825C08L5/04D04H1/4309A61L2430/34A61L15/225C08K2003/325C08K3/32A61F13/00987
Inventor 韩颖超赵刚戴红莲
Owner WUHAN UNIV OF TECH
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