Hydroxyapatite nano-complex particle, preparation and uses thereof

A nano-composite particle, hydroxyapatite technology, applied in phosphorus compounds, chemical instruments and methods, fluorescence/phosphorescence, etc., can solve problems such as poor dispersion stability, and achieve the effects of low cost, environmental friendliness, and wide sources

Inactive Publication Date: 2009-08-19
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cellulose-hydroxyapatite composite materials obtained by the above preparation method, one is the hydroxyapatite crystal layer grown on the surface of cellulose, and the other is the composite particles synthesized by chemical modification, these composite materials still exist Agglomeration phenomenon, poor dispersion stability in aqueous medium, severely restricts its application

Method used

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  • Hydroxyapatite nano-complex particle, preparation and uses thereof
  • Hydroxyapatite nano-complex particle, preparation and uses thereof
  • Hydroxyapatite nano-complex particle, preparation and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] In this embodiment, the process steps for preparing hydroxyapatite nanocomposite particles are as follows:

[0033] (1) Dissolution of cellulose

[0034] Take 0.05g of 500-mesh moso bamboo cellulose powder and add it to 12.50mL of NaI-NaNO with a concentration of 1.0mol / L 3 -in NaBr aqueous solution (the concentration of three kinds of sodium salts in the solution is 1.0mol / L), heated to 60°C under magnetic stirring (stirring speed is 400 rev / min) and keeps the temperature at 60°C to make Phyllostachys pubescens The cellulose powder is completely dissolved (about 6 hours) to form a cellulose-salt homogeneous aqueous solution;

[0035] (2) Reaction synthesis

[0036] After the bamboo cellulose-salt solution prepared in step (1) was cooled to room temperature, under stirring at a speed of 400 rpm, Ca(NO 3 )2 4H 2 O aqueous solution, Na with a concentration of 0.05mol / L 2 HPO 4 12H 2 Each 25mL of O aqueous solution, the Ca / P=1.2:1 of reaction system;

[0037] Then,...

Embodiment 2

[0042] In this embodiment, the process steps for preparing hydroxyapatite nanocomposite particles are as follows:

[0043] (1) Dissolution of cellulose

[0044] Get 0.03kg400 mesh pine wood cellulose powder, join 45L concentration and be the ZnCl of 5mol / L 2 In the aqueous solution, heat to 100°C under magnetic stirring (stirring speed is 400 rpm) and keep the temperature at 100°C to completely dissolve the pine wood cellulose powder (about 2 hours), forming a cellulose-salt homogeneous aqueous solution;

[0045] (2) Reaction synthesis

[0046] After the pine wood cellulose-salt solution prepared in step (1) was cooled to room temperature, under stirring at a speed of 400 rpm, Ca(NO 3 ) 2 4H 2 O aqueous solution, concentration 0.25mol / L (NH 4 ) 2 HPO 4 2H 2 Each 2.5L of O aqueous solution, the Ca / P=2.0:1 of reaction system;

[0047] Subsequently, adjust the pH value of the reaction system with ammonia water with a concentration of 1.0 mol / L and HCl with a concentratio...

Embodiment 3

[0052] In this embodiment, the process steps for preparing hydroxyapatite nanocomposite particles are as follows:

[0053] (1) Dissolution of cellulose

[0054] Take 0.10g 300 mesh defatted cotton cellulose powder, add to 50mL ZnCl with a concentration of 2mol / L 2 -Mg(NO 3 ) 2 -MgCl 2 In the aqueous solution (the concentration of the substance of the three metal salts is 2mol / L), heat to 80°C under magnetic stirring (stirring speed is 400 rpm) and keep the temperature at 80°C to make the degreased cotton cellulose powder completely Dissolving (about 4 hours), forming a homogeneous aqueous solution of cellulose-salt;

[0055] (2) Reaction synthesis

[0056] After the defatted cotton cellulose-salt solution prepared in step (1) was cooled to room temperature, under stirring at a speed of 400 rpm, Ca(NO 3 ) 2 4H 2 O aqueous solution, NaH with a concentration of 0.6mol / L 2 PO 4 2H 2 Each 15mL of O aqueous solution, the Ca / P=1.67:1 of reaction system;

[0057] Then, adj...

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Abstract

The invention relates to hydroxyapatite composite nanoparticles, which comprise hydroxyapatite of which mass friction is 95 to 99.5 percent and cellulose with the mass friction of between 0.5 and 5 percent, wherein the appearance of the hydroxyapatite composite nanoparticles is a needle of which the length is between 50 and 310 nanometers and the width is between 3 and 30 nanometers. A method for preparing the hydroxyapatite composite nanoparticles comprises the following technological steps: (1) taking a metallic soluble salt aqueous solution or an ammonium salt aqueous solution as a solvent to dissolve the cellulose at a temperature of between 60 and 100 DEG C; (2) adding a calcium salt aqueous solution and a phosphate aqueous solution into a cellulose-salt solution after the cellulose-salt solution prepared in the step (1) is cooled to the room temperature, controlling the mol ratio of Ca to P of a reaction system is 1.2-2.0:1, subsequently adjusting the pH value of the reaction system, stopping stirring when the pH value is stably between 10 and 12, and keeping the obtained solution stand and performing aging for at least 48 hours; and (3) collecting and drying products. The composite particles have stable dispersity in an aqueous-phase medium, and can be taken as a fluorescent molecular carrier.

Description

technical field [0001] The invention belongs to the field of cellulose-hydroxyapatite composite materials, and in particular relates to a hydroxyapatite nanocomposite particle and a preparation method and application thereof. Background technique [0002] Nanoacicular hydroxyapatite has been widely used in biomedical fields such as tissue repair, tumor therapy, and fluorescent diagnostic probes (Qiu H, et al., A citric acid-based hydroxyapatite composite for orthopedic implants, Biomaterials, 2006, 27 , 5845-5854; Mondejar SP, et al.Lanthanide-doped calcium phosphatenanoparticles with high internal crystallinity and with a shell of DNA as fluorescent probes incell experiments, Journal of Materials Chemistry, 2007, 17, 4153-4159), conventional preparation techniques Mainly hydrothermal synthesis method (Liu HS, et al., Hydroxyapatite synthesized by a simplified hydrothermal method, Ceramics International, 1997, 23, 19-25) that introduces surfactant, the method has such disadv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61K47/02C12N15/63G01N21/64
Inventor 李旭东陈震华周慧慧桑琳王彩红顾忠伟张兴栋
Owner SICHUAN UNIV
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