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Sodium alginate-hydroxyapatite hybrid nanoparticles and preparation method thereof

A technology of hybrid nanoparticles and hydroxyapatite, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of affecting the therapeutic effect and the inaccessibility of drug carriers, and increase the specific surface area. , Good drug treatment effect, the effect of improving drug loading rate

Inactive Publication Date: 2018-05-25
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the literature, the prepared sodium alginate hydroxyapatite nanoparticles are spherical, with a particle size of 160nm to 650nm, so the drug carrier cannot enter the nucleus. For anticancer drugs, if they cannot enter the nucleus and release, it will inevitably affect the therapeutic effect

Method used

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  • Sodium alginate-hydroxyapatite hybrid nanoparticles and preparation method thereof
  • Sodium alginate-hydroxyapatite hybrid nanoparticles and preparation method thereof
  • Sodium alginate-hydroxyapatite hybrid nanoparticles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Add 0.32 kg of sodium alginate with a molecular weight of 120 KDa to deionized water at room temperature to prepare 40 L of sodium alginate solution. Add CaCl with a concentration of 0.01 mol / L to the resulting sodium alginate solution at a stirring speed of 400 rpm 2 4H 2 O aqueous solution and Na at a concentration of 0.01 mol / L 2 HPO 4 12H 2Each 1 L of O aqueous solution, followed by NaOH aqueous solution with a concentration of 0.1 mol / L and hydrochloric acid with a concentration of 0.1 mol / L was used to adjust the pH value of the reaction system. When the pH value was stabilized at 11, the stirring was stopped and left to age for 7 days. After standing and aging, the precipitate was collected by centrifugation at a speed of 5000 rpm, washed with deionized water for 3 times, and then the washed precipitate was placed in a freeze dryer and freeze-dried at -20°C (Negative pressure: 0.1Mpa) After 52 hours, sodium alginate-hydroxyapatite hybrid nanoparticles were ob...

Embodiment 2

[0036] Add 0.16 kg of sodium alginate with a molecular weight of 150 KDa to deionized water at room temperature to prepare 40 L of sodium alginate solution. Add CaCl with a concentration of 0.4 mol / L to the resulting sodium alginate solution at a stirring speed of 400 rpm 2 4H 2 O aqueous solution and concentration of 0.2mol / L (NH 4 ) 2 HPO 4 2H 2 Each 1 L of O aqueous solution, followed by NaOH aqueous solution with a concentration of 0.1 mol / L and hydrochloric acid with a concentration of 0.1 mol / L is used to adjust the pH value of the reaction system to be stable at 11, stop stirring, and leave to age for 7 days. After standing and aging, the precipitate was collected by centrifugation at a speed of 5000 rpm, washed with deionized water for 4 times, and then the washed precipitate was placed in a freeze dryer and freeze-dried at -40°C (with a negative pressure of 0.1Mpa) for 48 hours, sodium alginate-hydroxyapatite hybrid nanoparticles were obtained.

[0037] The test...

Embodiment 3

[0039] Add 0.08 kg of sodium alginate with a molecular weight of 150 KDa to deionized water at room temperature to prepare 40 L of sodium alginate solution. Add CaCl with a concentration of 0.6 mol / L to the resulting sodium alginate solution at a stirring speed of 400 rpm 2 4H 2 O aqueous solution and NaH with a concentration of 0.6mol / L 2 PO 4 2H 2 Each 1 L of O aqueous solution, followed by NaOH aqueous solution with a concentration of 0.1 mol / L and hydrochloric acid with a concentration of 0.1 mol / L is used to adjust the pH value of the reaction system to be stable at 11, stop stirring, and leave to age for 7 days. After standing and aging, the precipitate was collected by centrifugation at a speed of 5000 rpm, washed with deionized water for 4 times, and then the washed precipitate was placed in a freeze dryer and freeze-dried at -40°C (with a negative pressure of 0.1Mpa) for 48 hours, sodium alginate-hydroxyapatite hybrid nanoparticles were obtained.

[0040] The tes...

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Abstract

A sodium alginate-hydroxyapatite hybrid nanoparticle, which is composed of hydroxyapatite with a mass fraction of 65% to 99.5% and sodium alginate with a mass fraction of 0.5% to 35%, and its shape is needle-shaped , the length of the needle is 10-70nm, and the width of the needle is 3-20nm. Preparation method: dissolve alginic acid polysaccharides in deionized water to obtain an alginic acid polysaccharide solution with a mass concentration of 0.2% to 0.8%, add calcium salt solution and phosphate solution to the obtained alginic acid polysaccharide solution under stirring, the obtained The addition of the calcium salt solution and the phosphate solution is limited to (1~2.0):1 with the mol ratio of Ca / P in the reaction system, and the volume ratio of the calcium salt solution and the alginate polysaccharide solution is 1:(20 ~40), and then adjust the pH value of the reaction system to 10~12 and stop stirring, stand and age for at least 5 days, collect the reaction product after standing and aging, and dry the reaction product. The above-mentioned sodium alginate-hydroxyapatite hybrid nanoparticles are particularly suitable as anticancer drug carriers.

Description

technical field [0001] The invention belongs to the field of hydroxyapatite composite materials, in particular to a sodium alginate-hydroxyapatite composite material and a preparation method thereof. Background technique [0002] Sodium alginate is a polysaccharide sodium salt extracted from natural brown algae, which is a block copolymer of linearly bonded β-D-mannuronic acid (M) and α-L-guluronic acid (G) substances, which in aqueous solution can interact with Ca 2+ Complexation quickly forms a gel, which has good gel properties, biocompatibility and biodegradability, and is widely used in the food industry, pharmaceutical industry and daily chemical industry. As for the sodium alginate-hydroxyapatite composite material and its preparation method, there are not many published prior art. [0003] The patent application with publication number CN104117341A discloses a nano-hydroxyapatite / sodium alginate composite material used as a heavy metal adsorbent and its preparation...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K31/704A61P35/00
Inventor 李旭东任肖湘王彦明苏文
Owner SICHUAN UNIV
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