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Collagen/hydroxyapatite composite artificial bone and preparation method thereof

A technology of hydroxyapatite and collagen, which is applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of lack of collagen bone tissue repair components, component addition barriers, etc., to meet the needs of clinical differentiation and cost The effect of low investment and short cycle

Inactive Publication Date: 2017-05-10
WUHAN YIJIABAO BIOMATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In recent years, the calcium-phosphorus system artificial bone that has appeared on the market is widely used in bone defect filling, but it only contains the inorganic components of bone tissue and lacks collagen and other components that promote bone tissue repair.
Most of the calcium-phosphorus system artificial bones are sintered at high temperature, which brings insurmountable obstacles to the addition of components that promote bone tissue repair.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0023] (1) Dissolve 10g of type I collagen in 2% acetic acid solution to prepare a certain concentration of collagen solution, and put 10g of hydroxyapatite in the collagen solution according to the mass ratio of collagen to hydroxyapatite at 1:1 , stir mechanically until evenly mixed;

[0024] Step 2: Put the collagen-hydroxyapatite mixture slurry in the mold, pre-freeze at -20°C for 12 hours, then freeze-dry at -50°C for 48 hours, and then freeze-dry the porous material Pulverize to obtain blended powder;

[0025] Step 3: Dissolve polydioxanone in tetrafluoroacetic acid to form a 0.04g / mL solution, add the blended powder to the polydioxanone solution at 0.8g / ml, and obtain a uniform solution by mechanical stirring mixture;

[0026] Step 4: Put the mixture in step 3 into a mold, pre-freeze at -20°C for 12 hours, then freeze-dry and shape at -50°C for 48 hours, and then cold-press the freeze-dried product to obtain collagen / Hydroxyapatite composite artificial bone pre-prod...

Embodiment example 2

[0030] (1) Dissolve 10g of type I collagen in 2% acetic acid solution to prepare a collagen solution of a certain concentration, and place 20g of hydroxyapatite in the collagen solution according to the mass ratio of collagen to hydroxyapatite at 1:2 , stir mechanically until evenly mixed;

[0031] Step 2: Put the collagen-hydroxyapatite mixture slurry in the mold, pre-freeze at -20°C for 12 hours, then freeze-dry at -50°C for 48 hours, and then freeze-dry the porous material Pulverize to obtain blended powder;

[0032] Step 3: Dissolve polydioxanone in tetrafluoroacetic acid to form a 0.04g / mL solution, add the blended powder to the polydioxanone solution at 0.8g / ml, and obtain a uniform solution by mechanical stirring mixture;

[0033] Step 4: Put the mixture in step 3 into a mold, pre-freeze at -20°C for 12 hours, then freeze-dry and shape at -50°C for 48 hours, and then cold-press the freeze-dried product to obtain collagen / Hydroxyapatite composite artificial bone pre-...

Embodiment example 3

[0036] (1) Dissolve 10g of type I collagen in 2% acetic acid solution to prepare a certain concentration of collagen solution, and put 10g of hydroxyapatite in the collagen solution according to the mass ratio of collagen to hydroxyapatite at 1:1 , stir mechanically until evenly mixed;

[0037] Step 2: Put the collagen-hydroxyapatite mixture slurry in the mold, pre-freeze at -20°C for 12 hours, then freeze-dry at -50°C for 48 hours, and then freeze-dry the porous material Pulverize to obtain blended powder;

[0038] Step 3: Dissolve polydioxanone in tetrafluoroacetic acid to form a 0.02g / mL solution, add the blended powder to the polydioxanone solution at 0.8g / ml, and obtain a uniform solution by mechanical stirring mixture;

[0039] Step 4: Put the mixture in step 3 into a mold, pre-freeze at -20°C for 12 hours, then freeze-dry and shape at -50°C for 48 hours, and then cold-press the freeze-dried product to obtain collagen / Hydroxyapatite composite artificial bone pre-prod...

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Abstract

The invention relates to a collagen / hydroxyapatite composite artificial bone and a preparation method thereof. The artificial bone comprises type I collagen, hydroxyapatite and poly-p-dioxanone. The preparation method disclosed by the invention comprises the following steps: adding the type I collagen in a solvent to prepare a collagen solution, adding an appropriate amount of the hydroxyapatite and performing uniform stirring; placing the mixed slurry in a mold, performing pre-freezing, performing freeze-dried forming, and crushing the freeze-dried forming porous material to obtain blended powder; dissolving the poly-p-dioxanone in tetrafluoroacetic acid to prepare a solution, adding the blended powder in proportion, performing uniform stirring and performing cold press forming; and washing the formed pre-product with water, and drying the washed pre-product to obtain collagen / hydroxyapatite composite artificial bone. The preparation method disclosed by the invention is simple and low in the production cost. The collagen / hydroxyapatite composite artificial bone has compressive strength of 75-90MPa and favorable toughness, so that the collagen / hydroxyapatite composite artificial bone can meet requirements for bone filling and partial replacement in orthopedic surgery.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a collagen / hydroxyapatite composite artificial bone and a preparation method thereof. Background technique [0002] At present, bone defects caused by surgical resection of bone tumors, trauma, osteomyelitis, etc. have a serious impact on the own bone tissue. Although autologous bone has good biocompatibility and osteoinductive type, it will bring more pain to patients and cause inflammation and complications in the donor area. Allogeneic bone often has problems such as immune rejection and the introduction of new viruses or toxins. Therefore, the design and development of new artificial bone repair materials has important market value and social benefits. In human natural bone, the inorganic component is mainly hydroxyapatite, accounting for about 65% of the bone mass; the organic component is mainly type I collagen fibers, accounting for 34% of the bone mass. Hydroxyapatit...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/56A61L27/58
CPCA61L27/46A61L27/56A61L27/58A61L2430/02C08L67/04
Inventor 柯林松唐小雄王喆
Owner WUHAN YIJIABAO BIOMATERIAL CO LTD
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