Alpha-calcium sulfate hemihydrate/hydroxyapatite composite granule with nuclear shell structure and preparation thereof

A technology of hydroxyapatite and calcium sulfate hemihydrate, which is applied in medical science, prosthesis and other directions, can solve problems such as not being well controlled, and achieve the effects of good clinical application prospect, simple and easy preparation method and simple operation.

Inactive Publication Date: 2012-06-13
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, calcium sulfate and calcium phosphate in its microstructure are simply mixed, and its dissolution and degradation behaviors still follow the characteristics of calcium sulfate and calcium phosphate, and have not been well regulated.

Method used

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  • Alpha-calcium sulfate hemihydrate/hydroxyapatite composite granule with nuclear shell structure and preparation thereof
  • Alpha-calcium sulfate hemihydrate/hydroxyapatite composite granule with nuclear shell structure and preparation thereof
  • Alpha-calcium sulfate hemihydrate/hydroxyapatite composite granule with nuclear shell structure and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Get the deionized water of 40ml as solvent, add the sodium citrate of 0.02g and the magnesium sulfate that massfraction is 0.8g, stir until dissolving completely, make crystallization solution; Add 10g calcium sulfate dihydrate powder (analytically pure grade ), and then add 7.5g of hydroxyapatite to form a solid-liquid mixed system.

[0028] The prepared solid-liquid mixed system was placed in a hydrothermal kettle at 130°C for constant temperature treatment for 6 hours. After the hydrothermal treatment, the gas was released, and the hydrothermal kettle was quickly taken out, and the crude product was filtered out from the hydrothermal kettle. After being filtered and washed with water, it was dried in an oven at 90°C to obtain the final product in the form of granules.

[0029] Adopt X-ray diffractometer to carry out component analysis and component characterization to the final product of gained, XRD collection of illustrative plates is as follows figure 1 shown. f...

Embodiment 2

[0033] Get the deionized water of 40ml as solvent, add the succinic acid of 0.04g and the aluminum sulfate of 0.6g, stir until dissolving completely, make the transcrystal solution; Add 10g calcium sulfate dihydrate powder (analytically pure grade) wherein, add 5g of hydroxyapatite forms a solid-liquid mixed system.

[0034] The prepared solid-liquid mixed system was placed in a hydrothermal kettle at 160°C for constant temperature treatment for 4 hours. After the hydrothermal treatment, the gas was released, and the hydrothermal kettle was quickly taken out, and the crude product was filtered out from the hydrothermal kettle. After being filtered and washed with water, it was dried in an oven at 110° C. to obtain the final product in the form of granules.

[0035] Adopt X-ray diffractometer to carry out component analysis and component characterization to the final product of gained, XRD collection of illustrative plates is as follows Figure 5 shown. Figure 5 Among them, ...

Embodiment 3

[0038] Get the deionized water of 40ml as solvent, add the citric acid of 0.08g and the magnesium sulfate of 0.2g, stir until dissolving completely, make crystallization solution; 2.5g of hydroxyapatite forms a solid-liquid mixed system.

[0039] The prepared solid-liquid mixed system was placed in a hydrothermal kettle at 140°C for constant temperature treatment for 8 hours. After the hydrothermal treatment, the gas was released, and the hydrothermal kettle was quickly taken out, and the crude product was filtered out from the hydrothermal kettle. After being filtered and washed with water, it was dried in an oven at 90°C to obtain the final product in the form of granules. After characterization, the final product is α-calcium sulfate hemihydrate / hydroxyapatite composite particles with core-shell structure.

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Abstract

The invention discloses an alpha-calcium sulfate hemihydrate/hydroxyapatite composite granule with a nuclear shell structure and preparation thereof. The composite granule has a microstructure in which the hydroxyapatite wraps the alpha-calcium sulfate hemihydrate. The preparation method comprises the steps of: using deionized water as a solvent, dissolving a proper dosage of organic crystal modifier and inorganic salt crystal modifier, adding calcium sulfate dehydrate and hydroxyapatite, and performing hydrothermal synthesis under certain technical parameters. According to the invention, the alpha-calcium sulfate hemihydrate and the hydroxyapatite are compounded in the microstructure so as to adjust the quick consolidation defect of pure alpha-calcium sulfate hemihydrate to improve the injection performance thereof, and a microstructure with a controllable wrapping degree can be formed to adjust and control the biodegradation performance thereof, so that the composite granule has a brilliant clinical application prospect.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, and in particular relates to a core-shell structure alpha-calcium sulfate hemihydrate / hydroxyapatite composite particle and a preparation method thereof. Background technique [0002] Calcium sulfate (CS) has been used clinically as a bone graft material for more than 100 years, and its safety in the human body has been confirmed by many experiments. Calcium sulfate has the characteristics of good histocompatibility, high osteoinductive activity, slightly acidic environment formed after biodegradation, and calcium phosphate crystals can attract osteoclasts and accelerate new bone formation. However, calcium sulfate degrades too fast in the body, which has become a factor limiting its clinical application. [0003] The OsteoSet and MIIG series of medical calcium sulfate bone substitutes successively developed by Wright Medical Technology Company of the United States ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/50
Inventor 翁文剑陈怡坚程逵黄海生李坚
Owner ZHEJIANG UNIV
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