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PLGA/Hydroxyapatite Composite Biomaterial and Method of Making the Same

InactiveUS20090048358A1Fastly and highly and uniformly coatedGood at propagatingCosmetic preparationsImpression capsDiseaseApatite
Tissue engineering is a growing field where new materials are being developed for implantation into the body. One important area involves bone graft materials to replace areas of bone lost to trauma or disease. Traditionally, graft material may be harvested from the bone of the individual receiving the graft material. However, this requires an additional surgery and additional recovery. Bone also may be taken from others, or even cadavers, but this introduces biocompatibility problems as well as the risk of disease transfer. Ideally, a biocompatible material is sought that will act as a filler with appropriate mechanical strength, encourage bone healing, and degrade to allow new bone ingrowth without the risk of disease transfer. The present invention is a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and nano-sized hydroxyapatite particles exposed on its surface using a gas foaming particle leaching (GF / PL) method. A further embodiment of this invention involves coating this PLGA / hydroxyapatite biomaterial with an adherent, fast, uniform coating of a mineral such as apatite. The PLGA polymer portion of the composite provides sufficient mechanical strength to replace bone and is degradable over time to allow new bone tissue ingrowth. The incorporated hydroxyapatite particles increase the composite material's osteogenic properties by providing sites for tissue attachment and propagation. Finally, a uniform coating of mineral apatite on the surface of this novel biomaterial composite further enhances its osteogenic qualities.
Owner:NANO ORTHOPEDICS

PLGA/hydroxyapatite composite biomaterial and method of making the same

InactiveUS20080065228A1Fastly and highly and uniformly coatedGood at propagatingCosmetic preparationsBone implantApatiteBiocompatibility Testing
Tissue engineering is a growing field where new materials are being developed for implantation into the body. One important area involves bone graft materials to replace areas of bone lost to trauma or disease. Traditionally, graft material may be harvested from the bone of the individual receiving the graft material. However, this requires an additional surgery and additional recovery. Bone also may be taken from others, or even cadavers, but this introduces biocompatibility problems as well as the risk of disease transfer. Ideally, a biocompatible material is sought that will act as a filler with appropriate mechanical strength, encourage bone healing, and degrade to allow new bone ingrowth without the risk of disease transfer. The present invention is a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and nano-sized hydroxyapatite particles exposed on its surface using a gas foaming particle leaching (GF / PL) method. A further embodiment of this invention involves coating this PLGA / hydroxyapatite biomaterial with an adherent, fast, uniform coating of a mineral such as apatite. The PLGA polymer portion of the composite provides sufficient mechanical strength to replace bone and is degradable over time to allow new bone tissue ingrowth. The incorporated hydroxyapatite particles increase the composite material's osteogenic properties by providing sites for tissue attachment and propagation. Finally, a uniform coating of mineral apatite on the surface of this novel biomaterial composite further enhances its osteogenic qualities.
Owner:NANO ORTHOPEDICS

Rotary piston combustion engine

Combustion engine (10) comprising a stator (11) provided with a compartment (16), inside which a rotor (20) is mounted rotatable, which comprises two parts (22, 23) each comprising a peripheral surface (47) and articulated one with respect to the other and both mounted rotatable, around the same axis of rotation (21) substantially coaxial with the compartment (16). The combustion engine (10) comprises kinematisms (60) to coordinate cyclically the rotations of the two parts (22, 23) around the axis of rotation (21), so that each of the parts (22, 23) accelerates or decelerates synchronously with respect to the other, while still both rotating in the same direction and at the same average angular velocity. Each part (22, 23) comprises a first radial arm (22a, 23a, 22b, 23b) provided with a first lateral surface (45) orthogonal to the plane of rotation, to cooperate cyclically with a corresponding second lateral surface (46), also substantially orthogonal to the plane of rotation, a second adjacent radial arm (22a, 23a, 22b, 23b) to define a combustion chamber (31, 32, 33, 34). The first lateral surface (45) comprises a bevel (36, 37, 38, 39) oriented in the direction of the rotation, to define, with the second lateral surface (46) of the adjacent radial arm (22a, 23a, 22b, 23b), a combustion pre-chamber (40, 41, 42, 43) continuous with the combustion chamber (31, 32, 33, 34).
Owner:VALMAX

Rotary piston combustion engine

Combustion engine (10) comprising a stator (11) provided with a compartment (16), inside which a rotor (20) is mounted rotatable, which comprises two parts (22, 23) each comprising a peripheral surface (47) and articulated one with respect to the other and both mounted rotatable, around the same axis of rotation (21) substantially coaxial with the compartment (16). The combustion engine (10) comprises kinematisms (60) to coordinate cyclically the rotations of the two parts (22, 23) around the axis of rotation (21), so that each of the parts (22, 23) accelerates or decelerates synchronously with respect to the other, while still both rotating in the same direction and at the same average angular velocity. Each part (22, 23) comprises a first radial arm (22a, 23a, 22b, 23b) provided with a first lateral surface (45) orthogonal to the plane of rotation, to cooperate cyclically with a corresponding second lateral surface (46), also substantially orthogonal to the plane of rotation, a second adjacent radial arm (22a, 23a, 22b, 23b) to define a combustion chamber (31, 32, 33, 34). The first lateral surface (45) comprises a bevel (36, 37, 38, 39) oriented in the direction of the rotation, to define, with the second lateral surface (46) of the adjacent radial arm (22a, 23a, 22b, 23b), a combustion pre-chamber (40, 41, 42, 43) continuous with the combustion chamber (31, 32, 33, 34).
Owner:VALMAX
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