PLGA/Hydroxyapatite Composite Biomaterial and Method of Making the Same

a technology of hydroxyapatite and composite biomaterials, which is applied in the field of hydroxyapatite composite biomaterials and the field of making the same, can solve the problems of leaving voids formerly occupied by sodium chloride particles, and achieve the effects of fast, high, and uniform coating, and promote bone cell propagation and ingrowth better

Inactive Publication Date: 2009-02-19
NANO ORTHOPEDICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0001]This invention is a novel biomaterial that is especially useful in tissue engineering applications involving bone. It is a composite of poly(D,L-lactic-co-glycolic acid) (PLGA) and nano-sized hydroxyapatite, wherein the hydroxyapatite is highly exposed on the biomaterial surface. A further embodiment of this invention involves a ceramic, such as apatite, that is fastly, highly, and uniformly coated on the biomaterial surface. This new biomaterial is advantageous because it promotes bone cell propagation and ingrowth better than current materials.

Problems solved by technology

The sodium chloride particles are subsequently leached out of the material by immersing the disk in distilled water for a lengthy period of time, thus leaving voids formerly occupied by the sodium chloride particles.

Method used

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  • PLGA/Hydroxyapatite Composite Biomaterial and Method of Making the Same
  • PLGA/Hydroxyapatite Composite Biomaterial and Method of Making the Same
  • PLGA/Hydroxyapatite Composite Biomaterial and Method of Making the Same

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example 1

[0064]Porous PLGA / HA composite scaffolds were fabricated by the modification of a previously described GF / PL method of 24. Harris L D, Kim B S, Mooney D J. Open pore biodegradable matrices formed with gas foaming. J Biomed Mater Res 1998; 42: 396-402. PLGA / HA composites were prepared with 75:25 PLGA particles (diameter=100-200 mm, molecular weight=100,000 Da, Birmingham Polymers, Birmingham, Ala.), HA nanoparticles (diameter=approximately 100 nm, Berkeley Advanced Biomaterials Inc., Berkeley, Calif.), and sodium chloride particles (diameter=100-200 mm, Sigma, St. Louis, Mo.). The PLGA pellets were ground using a Tekmar grinder (Bel-Art Products, Pequannock, N.J.) and sieved to obtain particles ranging from 100 to 200 mm. The salt particles were sieved to yield a range of sizes from 100 to 200 mm. The polymer particles were mixed with the HA and NaCl particles. The PLGA / HA / NaCl mass ratio was 1:1:9. The mixture was loaded into a disk mold (diameter=1.35 cm; Aldrich Chemical Co., Milw...

example 2

[0091]Increasing interest has currently been focused on polymer / ceramic composite materials as bone substitutes because these materials have advantages over ceramic scaffolds and polymer scaffolds for bone tissue engineering. Calcium phosphate-based ceramics, such as hydroxyapatite (HA) and tricalcium phosphate, have been used as bone substitutes, but these materials have poor mechanical performance. Most synthetic polymer biomaterials have low surface wettability due to their composition of noncharged elements. Such hydrophobic surfaces are unfavorable to osteogenic cells as they show a lower proliferative and a higher apoptotic rate on hydrophobic surfaces than on hydrophilic surfaces. In addition, these polymeric biomaterials have a bioinert surface that lacks bioactive functions for bone formation, therefore evoking minimal tissue responses. An essential requirement for bone grafts is the ability to create a bond with the living host bone through the formation of a biologically ...

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Abstract

Tissue engineering is a growing field where new materials are being developed for implantation into the body. One important area involves bone graft materials to replace areas of bone lost to trauma or disease. Traditionally, graft material may be harvested from the bone of the individual receiving the graft material. However, this requires an additional surgery and additional recovery. Bone also may be taken from others, or even cadavers, but this introduces biocompatibility problems as well as the risk of disease transfer. Ideally, a biocompatible material is sought that will act as a filler with appropriate mechanical strength, encourage bone healing, and degrade to allow new bone ingrowth without the risk of disease transfer. The present invention is a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and nano-sized hydroxyapatite particles exposed on its surface using a gas foaming particle leaching (GF / PL) method. A further embodiment of this invention involves coating this PLGA / hydroxyapatite biomaterial with an adherent, fast, uniform coating of a mineral such as apatite. The PLGA polymer portion of the composite provides sufficient mechanical strength to replace bone and is degradable over time to allow new bone tissue ingrowth. The incorporated hydroxyapatite particles increase the composite material's osteogenic properties by providing sites for tissue attachment and propagation. Finally, a uniform coating of mineral apatite on the surface of this novel biomaterial composite further enhances its osteogenic qualities.

Description

SUMMARY OF THE INVENTION[0001]This invention is a novel biomaterial that is especially useful in tissue engineering applications involving bone. It is a composite of poly(D,L-lactic-co-glycolic acid) (PLGA) and nano-sized hydroxyapatite, wherein the hydroxyapatite is highly exposed on the biomaterial surface. A further embodiment of this invention involves a ceramic, such as apatite, that is fastly, highly, and uniformly coated on the biomaterial surface. This new biomaterial is advantageous because it promotes bone cell propagation and ingrowth better than current materials.BACKGROUND[0002]The ideal bone graft would replace bone defects, such as those from disease or trauma, with a material that allows bone cells to grow into the affected area, thus restoring the bone to its original condition. Currently, autografts are the best material for bone repair because they are biocompatible and there is little risk of disease transfer. However, the downside of autografts is that a separat...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F2/02C08J9/35B29C43/00
CPCA61L27/44A61L27/46A61L27/56A61L2400/12A61L2430/02C08L67/04A61K8/72
Inventor KIM, BYUNG-SOO
Owner NANO ORTHOPEDICS
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