Active composition for repairing hard tissue and its prepn

Abstract

The present invention relates to surgical material. The material includes biological absorbable polymer 10-90 wt%, un-sintered calcium phosphate salt 9-80 wt% and active matter less than 50 wt%. The biologically absorbable polymer includes polyester, chitosan, chondroitin sulfate, collagen, alginate, etc.; and the calcium phosphate salt is un-sintered hydroxyapatite or tricalcium phosphate of granularity less than 100 microns. The hard tissue repairing material is prepared through mixing biologically absorbable polymer, un-sintered calcium phosphate salt, etc. dispersed in solvent, freeze drying to eliminate solvent and obtain porous material and mixing with active matter. The composition has the function of promoting bone healing and excellent biocompatibility.

Description

1. Technical field:

[0001] The invention relates to an active composition for hard tissue repair and a preparation method thereof, and belongs to the technical field of preparation of materials for medical surgery. 2. Background technology:

[0002] Hard tissues such as human bones and teeth are damaged due to disease or trauma, and artificial materials are required for repair or correction. Such repair materials include metals, inorganic materials, polymer materials, etc.

[0003] Bone repair materials made of stainless steel or titanium alloy have high strength, low cost, and high frequency of use, but stress shielding may occur, which may lead to bone resorption, delay bone healing, and poor tissue compatibility. lead to inflammatory reactions, etc.

[0004] Hydroxyapatite and tricalcium phosphate are commonly used bioceramics. Calcium phosphate bone cement is also commonly used in hard tissue repair. It has good biocompatibility. Hydroxyapatite can also induce osteogen...