Fibrous hydrogel and preparation method thereof

A hydrogel and fiber technology, applied in the field of medical materials and their preparation, can solve the problems of complex preparation steps, toxicity, inconvenience in use and the like

Active Publication Date: 2013-10-23
JOLLITY ENTERPRISE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned chemical cross-linking agents and chemical modifiers either often make the preparation steps more complicated and difficult to control, or they often have toxicity.
On the other hand, because it is in the form of an amorphous hydrogel, it cannot be quickly frozen to form a wound protective film after being applied to the wound. It often requires another layer of dressing to be used together to protect it from indirect contact with the outside world. Inconvenient to use

Method used

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  • Fibrous hydrogel and preparation method thereof
  • Fibrous hydrogel and preparation method thereof
  • Fibrous hydrogel and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0027] 【Preparation method of fiber hydrogel】

[0028] The preparation method of the above-mentioned fiber hydrogel comprises the following steps: preparing hydrophilic fibers, stirring and dispersing them in the aqueous phase solution, preparing a temperature-sensitive polymer solution, preparing a polysaccharide solution, and dissolving them in the hydrophilic fiber dispersion according to Add temperature-sensitive polymer solution, polysaccharide solution, and functional ingredients in sequence to form a hydrogel solution, and then slowly add a compounding agent while stirring to form a fiber-shaped hydrogel.

[0029] refer to figure 1 , which is a flow chart of the manufacturing method of fiber hydrogel. exist figure 1 Among them, the manufacturing method of the above-mentioned fiber hydrogel includes dispersing hydrophilic fibers in the water phase (step 110), adding a temperature-sensitive polymer solution (step 120), adding a polysaccharide solution (step 130), adding...

Embodiment 1

[0033] Embodiment one: various fiber hydrogels of carboxymethyl cellulose fibers

[0034] Firstly, for the preparation of carboxymethyl cellulose fibers, for example, reference can be made to the method disclosed in WO93 / 12275 "Cellulosic Fibers". The main methods are as follows. Firstly, the cotton fiber (Tencell or Lyocell fiber) is soaked in alkali solution (mixed solution of 40% NaOH and 95% EtOH, volume ratio 2:3) and reacted for 2 hours. Then react in an organic solvent solution of chloroacetic acid or sodium chloroacetate (mixture of 40% NaOH and 95% EtOH, volume ratio 2:3) for 20 hours to etherify to obtain sodium carboxymethyl cellulose Salt. Then, wash with 70-95% alcohol for several times, and dry in an oven at 65°C for 48 hours to obtain carboxymethyl cellulose fibers. In the aforementioned etherification reaction, factors such as the amount of chloroacetic acid or sodium chloroacetate, reaction temperature, and reaction time can be adjusted to regulate the hydr...

Embodiment 2

[0046] Example 2: Various fiber hydrogels of alginate fibers

[0047] In embodiment two, the alginate fibers used are all made by wet spinning, the spinning solution of wet spinning is 5wt% sodium alginate, and the forming solution is 5wt% calcium chloride (the solvent is a volume ratio of 1:1 alcohol and water). The diameter of the alginate fiber is 10-20 μm, and the fiber diameter and length of the alginate fiber can be 0.1-500 μm and 0.1 μm-10 cm, respectively, for example, 1-50 μm and 0.1 mm-5 cm, respectively.

[0048] Next, the production method of the alginate fiber hydrogel will be described. Take an appropriate amount of alginate fibers with a diameter and length of 12 μm and 0.1 mm-5 cm, respectively, add an appropriate amount of water phase solution and stir, so that the alginate fibers are dispersed in the water phase solution. Next, as in Example 1, add an appropriate amount of thermosensitive polymer solution at a temperature lower than the thermosensitive poly...

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Abstract

The invention provides fibrous hydrogel and a preparation method thereof and particularly relates to fibrous hydrogel of a fiber architecture, which is prepared by compounding hydrophilic fibers, temperature-sensitive macromolecules, polysaccharides and functional materials through charge gathering or ion exchanging. The fibrous hydrogel has better mechanical properties than those of the general hydrophilic macromolecules, so that the problems that the known hydrogel is relatively weak in strength and can encounter dissolution or decomposition loss can be solved; and the fibrous hydrogel can be applied to the preparation of a fibrous-hydrogel medical appliance, such as a hemostatic material, a wound dressing material, a tissue regeneration guiding substrate, a tissue adhesion preventing substrate, a tissue engineering substrate or an active substance controlled release substrate.

Description

technical field [0001] The present invention relates to a medical material and a preparation method thereof, in particular to a fiber-forming hydrogel and a preparation method thereof. Background technique [0002] With the prolongation of the average human life span and the increase of chronic diseases, the forms of clinical wounds are varied and complex. According to the wound site, size, exudate volume and nature, various wound dressing products have been developed. . Generally speaking, when the tissue is partial or full-thickness wound with little or no exudate, first to fourth degree pressure sore, lower extremity ulcer wound or first to second degree burn and necrotic tissue, you can choose the one with lower adsorption force. Hydrogel dressings. Because the hydrogel dressing can maintain a moist wound environment, avoid excessive drying of the wound, and promote the activation of polymorphonuclear leukocytes and macrophages, achieve autologous debridement, reduce t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/28A61L15/32A61L27/52A61L27/24A61L27/20A61L31/14A61L31/04C08J3/075
Inventor 游正仁廖淑贞尤中甫
Owner JOLLITY ENTERPRISE
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