Anti-infection venous catheter and preparation method thereof

An intravenous catheter and anti-infection technology, applied in the medical field, can solve the problems of high equipment and material cost, uneven drug distribution, poor anti-infection effect, etc., and achieve the effect of good anti-infection effect, uniform drug distribution and short drug effect.

Active Publication Date: 2012-06-20
BEIJING DEMAX MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Throughout the process, there is a risk of microbial infection, which has always been a difficult problem for clinicians. In order to better solve catheter infection, various anti-infection catheters have emerged as the times require, but most of the current anti-infection catheters have complex processes and cost. Higher, only coated on the surface, low drug content and other disadvantages
[0003] Chinese Patent Application No. 200980113241.4 discloses an anti-infective catheter comprising a composition in the form of a coating, the composition comprising pyrimidine analogs, polyurethane and cellulose or cellulose derivative polymers, this technology only Anti-infective drugs are coated on the surface of the catheter with low drug content, and the antibacterial agent is an uncommon broad-spectrum antibacterial drug with a narrow antibacterial range
Chinese Patent Application No. 200310111794.0 discloses a method for preparing a polyurethane medical anti-infection interventional catheter, which is to prepare an anti-infection masterbatch containing a composite anti-bacterial agent, mix it with polyurethane raw materials, and extrude it to obtain an anti-infection catheter. Functional polyurethane medical interventional catheter, the process is more complicated, the drug distribution is uneven, and the anti-infection effect is poor
Chinese patent application No. 97216603.3 discloses a medical anti-infection catheter. There is a silver-plated layer on the outer surface of the catheter. The silver and silver ions on the silver-coated layer on the outer surface of the catheter can inhibit and kill bacteria around it to prevent infection. , but the cost of equipment and materials required to implement this technology is high, and the process is complicated

Method used

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  • Anti-infection venous catheter and preparation method thereof
  • Anti-infection venous catheter and preparation method thereof
  • Anti-infection venous catheter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] The preparation process of the catheter body tube 1 includes the following steps:

[0075] 1) Prepare the soaking solution: prepare 40 mg / ml minocycline methanol solution, store it in a light-proof glass container with a cover, and the ambient temperature for operation and storage is 18-25°C;

[0076] 2) At a temperature of 18-25°C, completely immerse the main tube 1 (7F tube, 2.4mm in diameter) of the medical polyurethane catheter into the drug soaking solution, and when immersing, one end of the main tube enters first, and the air in the tube is discharged;

[0077] 3) The soaking time of the catheter main body tube 1 is 15 minutes, and the soaking process is protected from light; the ambient temperature for storage is 18-25°C;

[0078] 4) Take out the main tube 1 of the catheter, and dry it naturally at an ambient temperature of 18-25°C for 30 minutes, then put it into a vacuum drying oven, set the temperature at 60°C, and dry it in vacuum for 24 hours in the dark. ...

Embodiment 2

[0081] The preparation process of the catheter body tube 1 includes the following steps:

[0082] 1) Prepare the soaking solution: prepare 40 mg / ml minocycline methanol solution, store it in a light-proof glass container with a cover, and the ambient temperature for operation and storage is 18-25°C;

[0083] 2) At a temperature of 18-25°C, completely immerse the main tube 1 (7F tube, 2.4mm in diameter) of the medical polyurethane catheter into the drug soaking solution, and when immersing, one end of the main tube enters first, and the air in the tube is discharged;

[0084] 3) The soaking time of the catheter main body tube 1 is 30 minutes, and the soaking process is protected from light; the ambient temperature for storage is 18-25°C;

[0085] 4) Take out the main tube 1 of the catheter, and dry it naturally at an ambient temperature of 18-25°C for 30 minutes, then put it into a vacuum drying oven, set the temperature at 60°C, and dry it in vacuum for 24 hours in the dark. ...

Embodiment 3

[0088] The preparation process of the catheter body tube 1 includes the following steps:

[0089] 1) Prepare the soaking solution: prepare 40 mg / ml rifampicin methanol solution, store it in a light-proof glass container with a cover, and the ambient temperature for operation and storage is 18-25°C;

[0090] 2) At a temperature of 18-25°C, completely immerse the main tube 1 (7F tube, 2.4mm in diameter) of the medical polyurethane catheter into the drug soaking solution, and when immersing, one end of the main tube enters first, and the air in the tube is discharged;

[0091] 3) The soaking time of the catheter main body tube 1 is 15 minutes, and the soaking process is protected from light; the ambient temperature for storage is 18-25°C;

[0092] 4) Take out the main tube 1 of the catheter, and dry it naturally at an ambient temperature of 18-25°C for 30 minutes, then put it into a vacuum drying oven, set the temperature at 60°C, and dry it in vacuum for 24 hours in the dark.

...

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Abstract

The invention relates to an anti-infection venous catheter and a preparation method thereof. The venous catheter comprises a conduit main body tube, a tip end and a tube seat, and preferably also comprises a connecting seat and a plurality of epitaxial tubes, wherein the parts retained in a human body are the conduit main body tube and the tip end; and an anti-infection medicament rifampicin, an anti-infection medicament minocycline or combination of the two are uniformly loaded on the conduit main body tube. The preparation method of the venous catheter comprises the following steps of: dissolving the anti-infection medicament or the medicament combination to form soak solution; soaking the conduit into the soak solution to fully soak medicaments into the conduit; and drying to remove solvent to prepare the anti-infection venous catheter. During use, the medicaments are slowly released to fulfill the anti-infection aim of the conduit and avoid infection of the conduit during retention in the human body in surgery.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to an anti-infection medical catheter and a preparation method thereof. Background technique [0002] Venous catheters are mainly used for infusion of irritating and foaming drugs, intravenous infusion for more than seven days, measurement of central venous pressure and multiple blood samples; it is of great significance for the rescue of critically ill patients, major anesthesia and chemotherapy administration for cancer patients. Common venous catheters include central venous catheter (CVC), peripheral central catheter (PICC), hemodialysis catheter, etc. The catheter material is mainly medical polyurethane, and a few use medical silicone. Since the catheter is used in the internal environment of the human body, wounds will be generated during the operation, and the catheter needs to stay in the body for a period of time. Throughout the process, there is a risk of microbial infec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M25/00A61M1/14A61L29/16A61K31/65A61K31/496A61P31/04
CPCA61L29/16A61L2300/406A61L2300/45A61L2300/606A61M2025/0008A61M2025/0056
Inventor 戴华英邢雷王倩倩贾登强
Owner BEIJING DEMAX MEDICAL TECH
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