Nano-silver porous silicone rubber/polyurethane-containing double-layer artificial skin and preparation method thereof

An artificial skin and polyurethane technology, applied in medical science, bandages, prostheses, etc., can solve the problems of no bactericidal and bacteriostatic effects, short storage time, thin thickness, etc.

Inactive Publication Date: 2014-07-30
SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, Integra also has disadvantages in clinical use: it cannot be used for a long time, has high requirements on the wound surface, and requires secondary skin grafting to cover the wound surface, and is prone to infection after transplantation
However, Integra also has disadvantages in clinical use: because the upper layer is composed of allogeneic epidermal cells with high immunogenicity, the immune re

Method used

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  • Nano-silver porous silicone rubber/polyurethane-containing double-layer artificial skin and preparation method thereof
  • Nano-silver porous silicone rubber/polyurethane-containing double-layer artificial skin and preparation method thereof
  • Nano-silver porous silicone rubber/polyurethane-containing double-layer artificial skin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] 1) Preparation of loose porous polyurethane dermis

[0087] Add 10 parts of polyurethane to 100 parts of solvent, stir and dissolve at a temperature of 50°C to obtain a polyurethane solution with a concentration of 10wt%, add 50 parts of particle porogen, stir and mix evenly, then let the above solution stand for defoaming for 3 hours, The film was cast into a tetrafluoroethylene template, and the solvent was volatilized in an oven at a temperature of 100°C for 5 hours, and then soaked in a mixed solution of deionized water / ethanol = 1:0.5 for 2 days, then the particles were leached, and dried to form a film. Obtain a loose and porous polyurethane corium layer with a thickness of 0.1 mm and an average pore diameter of 30 μm;

[0088] 2) Preparation of nano-silver porous silicone rubber skin layer

[0089] a. Add 1 part of nano-silver antibacterial agent to a solvent of 80 parts of silicone rubber, and disperse 10 min in a power of 300W ultrasonic wave to obtain a conce...

Embodiment 2

[0100] 1) Preparation of loose porous polyurethane dermis

[0101] Add 20 parts of polyurethane to 250 parts of solvent, stir and dissolve at a temperature of 85°C to obtain a polyurethane solution with a concentration of 10wt%, add 250 parts of particle porogen, stir and mix evenly, and then defoam the above solution at a vacuum degree of 0.8MPa 50min, cast in a glass template to form a film, and volatilize the solvent in an oven at a temperature of 110°C for 7h, then soak in a mixed solution of deionized water / ethanol = 1:0.5 for 2d, perform particle leaching, and dry to form a film , obtain a loose and porous polyurethane dermis, its thickness is 2mm, and the average pore diameter is 150 μm;

[0102] 2) Preparation of nano-silver porous silicone rubber skin layer

[0103] a, 20 parts of nano-silver antibacterial agent is added in the solvent of 150 parts of silicone rubber, and the power is 500W ultrasonic dispersion for 15min to obtain a concentration of 14wt% nano-silver...

Embodiment 3

[0114] 1) Preparation of loose porous polyurethane dermis

[0115] Add 15 parts of polyurethane to 150 parts of solvent, stir and dissolve at a temperature of 55°C to obtain a polyurethane solution with a concentration of 8wt%, add 150 parts of particle porogen, stir and mix evenly, and then defoam the above solution at a vacuum of 0.7MPa 30min, cast into a polyester template to form a film, and volatilize the solvent in an oven at a temperature of 105°C for 6h, then soak in a mixed solution of deionized water / ethanol = 1:0.5 for 2d, then leach the particles, and dry it into Membrane to obtain a loose and porous polyurethane dermis layer with a thickness of 0.5mm and an average pore size of 100 μm;

[0116] 2) Preparation of nano-silver porous silicone rubber skin layer

[0117] a 10 parts of nano-silver antibacterial agents are added in the solvent of 120 parts of silicone rubber, and the power is 400W ultrasonic dispersion for 12min to obtain a concentration of 12wt% nano-s...

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Abstract

The invention discloses a nano-silver porous silicone rubber/polyurethane-containing double-layer artificial skin and a preparation method thereof. The nano-silver porous silicone rubber/polyurethane-containing double-layer artificial skin is characterized in that the artificial skin contains a dermis and epidermis double-layer structure; a dermis layer is prepared from loose porous polyurethane; an epidermis layer is prepared from antibacterial agent-containing silicone rubber. A preparation method of the dermis layer comprises the following steps: dissolving the polyurethane, adding a pore-foaming agent, defoaming, carrying out curtain coating so as to form a film, volatilizing a solvent, soaking so as to leach out the pore-foaming agent, and drying so as to obtain a porous polyurethane film. A preparation method of the epidermis layer comprises the following steps: dissolving a silicone rubber precursor, carrying out ultrasonic dispersion on a nano-silver solution, adding the pore-foaming agent, defoaming, carrying out blade coating or curtain coating so as to form a film, volatilizing a solvent, curing so as to obtain an embryonic film, soaking so as to leach out the pore-foaming agent, and drying so as to obtain a silicone rubber microporous film. The preparation method of the double-layer artificial skin comprises the following steps: coating the polyurethane film with polyvinyl alcohol, acid liquor and a crosslinking agent, then covering the polyurethane film by using the silicone rubber film, volatilizing a solvent, and carrying out heat treatment so as to obtain the double-layer artificial skin. The nano-silver porous silicone rubber/polyurethane-containing double-layer artificial skin has the effects of water resistance, air permeability, bacterial inhibition, virus killing and effective absorption of hydrops.

Description

technical field [0001] The invention relates to a nano silver-containing porous silicon rubber / polyurethane double-layer artificial skin and a preparation method thereof, belonging to the field of preparation and application of medical polymer materials. Background technique [0002] The skin is the largest organ of the human body and also the barrier between us and the external environment. It plays the roles of protection, sensation, temperature regulation, secretion, excretion, absorption and immunity. When the skin suffers from severe burns, trauma, etc., water, electrolyte imbalance and wound infection are the main factors that threaten the life of the patient. At this time, autologous skin is urgently needed to cover the wound. However, due to problems such as insufficient autologous skin donor sites, it is particularly important to prepare an artificial skin with certain strength, toughness, good waterproof and breathable performance, good biocompatibility, and low pr...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/60A61L27/54A61L15/30A61L15/26A61L15/44
Inventor 夏和生吴军刘波罗高兴徐瑞赵健费国霞
Owner SICHUAN UNIV
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