Wound repair composition and preparation method and application thereof

A wound repairing and composition technology, applied in the field of wound repairing compositions and preparation thereof, can solve the problems of slow wound healing, inconvenient nursing, strong pain, and achieve the effect of inhibiting infection, no adverse side effects, and alleviating pain. Effect

Active Publication Date: 2012-07-04
SHANGHAI RUNZHI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the defects of slow wound healing, poor curative effect, inconvenient nursing and strong pain during treatment of t

Method used

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  • Wound repair composition and preparation method and application thereof
  • Wound repair composition and preparation method and application thereof
  • Wound repair composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0041] Example 1 Wound repair spray

[0042] (1) Dissolve 0.3 kg of chitosan in a 1% (volume concentration) dilute hydrochloric acid solution, stir at room temperature until it is completely dissolved, and let stand to remove insoluble materials to prepare a chitosan glue with a mass concentration of 1% 30Kg, spare.

[0043] (2) Add 30Kg of Engelfi to 30Kg of the chitosan glue, then add 40Kg of physiological saline, shake well, adjust the pH to 6 after defoaming, and dispense into bottles in a sterile environment. A spray was obtained after 15 minutes of ultraviolet sterilization.

[0044] The content of the chitosan mortar in the wound healing composition prepared in this way is 30% by weight, the content of the extract of Staphylococcus aureus metabolites is 30% by weight, and the content of the physiological saline is 40% by weight.

Example Embodiment

[0045] Example 2 Wound repair spray

[0046] (1) Dissolve 1.5 kg of chitosan in a dilute hydrochloric acid solution with a concentration of 1% (volume concentration) to prepare 50 kg of chitosan glue with a mass concentration of 3% for use;

[0047] (2) Mix 50Kg of the chitosan mortar with 30Kg of Engelfi, then mix it with 20Kg of physiological saline, leave it to stand for defoaming, in a sterile environment, divide it into a spray bottle and irradiate it with gamma rays for 15 minutes Sterilize it.

[0048] The content of the chitosan mortar in the wound healing spray prepared in this way is 50% by weight, the content of the extract of Staphylococcus aureus metabolites is 30% by weight, and the content of the physiological saline is 20% by weight.

Example Embodiment

[0049] Example 3-7

[0050] (1) Dissolve chitosan in a dilute hydrochloric acid solution with a concentration of 1% (volume concentration), stir at room temperature until it is completely dissolved, and let stand to remove insoluble materials to prepare a chitosan slurry with a mass concentration of 2%. spare.

[0051] (2) Add Engelfi to the chitosan glue, then add physiological saline, shake well, adjust the pH value to 7.5 after defoaming, pack it into bottles in a sterile environment, and irradiate with gamma rays Sterilize for 15 minutes to get a spray.

[0052] Wherein, the dosages of the chitosan glue, Engelfi and physiological saline are shown in Table 1.

[0053] The content of the chitosan mortar in the wound healing spray prepared in this way is 20wt%, and the content of the extract of the Staphylococcus aureus metabolites is 10wt%, 20wt%, 30wt%, 40wt% and 50wt%.

[0054] Table 1

[0055]

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Abstract

The invention provides a wound repair composition. A formula of the wound repair composition comprises the following components in percentage by weight: 10-50 percent of chitosan mucilage, 10-50 percent of an extracting solution of a staphylococcus aureus metabolic product and 0-80 percent of medicament auxiliary materials, wherein the chitosan mucilage is a solution consisting of chitosan and an aqueous solution of an acid; the volume concentration of the acid in the aqueous solution of the acid is 0.8-1.2 percent; and the mass concentration of the chitosan in the chitosan mucilage is 1-3 percent. The invention further provides a preparation method of the wound repair composition and an application thereof as a medicament for treating skin or mucosal injure. The wound repair composition provided by the invention has the advantages of capabilities of promoting tissue repair, promoting wound healing and promoting the growth of epidermal cells, good infection inhibiting effect, high biocompatibility, realization of flat healed wounds, freeness from adverse side reactions, relieving in patient pain, convenience for nursing and using, easiness for storing, and the like.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a wound repair composition and its preparation method and application. Background technique [0002] Wound repair is one of the most important and fundamental issues in the field of trauma surgery. Ulcers, moderate to severe bedsores, wounds, erosions, burns and other chronic and difficult-to-heal wounds will form various wounds, which will cause the body to lose its natural barrier, inhibit the immune function of the body, and cause other diseases. [0003] There are many factors that affect wound healing, such as infection, growth factors, local nutritional barriers, etc., and they are very complex. At present, there are drugs that promote wound healing through external application of antibacterial drugs and growth factors in China, such as Bactobang and Beifuji. However, these medicines are mostly powders, ointments, creams or injections, with poor uniformity, adhesion and target...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61K9/12A61K9/06A61K9/70A61P17/02A61P31/00A61L15/40A61L15/28A61L15/44A61K31/722
Inventor 汤春琳
Owner SHANGHAI RUNZHI BIOTECH
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