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Wound repair composition and preparation method and application thereof

A wound repairing and composition technology, applied in the field of wound repairing compositions and preparation thereof, can solve the problems of slow wound healing, inconvenient nursing, strong pain, and achieve the effect of inhibiting infection, no adverse side effects, and alleviating pain. Effect

Active Publication Date: 2012-07-04
SHANGHAI RUNZHI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the defects of slow wound healing, poor curative effect, inconvenient nursing and strong pain during treatment of the existing wound repair composition, and to provide a brand-new wound repair composition especially The spray, gel and biofilm agent of the composition, and its preparation method and application

Method used

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  • Wound repair composition and preparation method and application thereof
  • Wound repair composition and preparation method and application thereof
  • Wound repair composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 Wound Repair Spray

[0042] (1) 0.3 kg of chitosan is dissolved in 1% (volume concentration) of dilute hydrochloric acid solution, stirred at room temperature until fully dissolved, left standing to remove insoluble matter, and making mass concentration is 1% chitosan glue 30Kg, spare.

[0043] (2) 30Kg Engefe is added to the chitosan glue of 30Kg, then add 40Kg normal saline, shake up, adjust the pH value to 6 after defoaming, subpackage in bottles under sterile environment, use Ultraviolet sterilized for 15 minutes to obtain a spray.

[0044] The content of the chitosan glue in the thus prepared wound repair composition is 30 wt%, the content of the extract of the metabolite of Staphylococcus aureus is 30 wt%, and the content of the physiological saline is 40 wt%.

Embodiment 2

[0045] Embodiment 2 Wound Repair Spray

[0046] (1) dissolving chitosan 1.5kg in the dilute hydrochloric acid solution of concentration 1% (volume concentration) makes mass concentration be that 3% chitosan glue 50Kg is subsequent use;

[0047] (2) Mix 50Kg of the chitosan glue with 30Kg of Engelfe, then mix with 20Kg of normal saline, let it stand for defoaming, put it in a spray bottle in a sterile environment, and irradiate it with gamma rays for 15 minutes Sterilize and that's it.

[0048] The content of the chitosan mucilage in the prepared wound surface repairing spray is 50 wt%, the content of the extract of the metabolite of Staphylococcus aureus is 30 wt%, and the content of the physiological saline is 20 wt%.

Embodiment 3-7

[0050] (1) Chitosan is dissolved in the dilute hydrochloric acid solution of concentration 1% (volume concentration), is stirred at room temperature until dissolving completely, leaves standstill to remove insoluble matter, makes the chitosan glue that mass concentration is 2%, spare.

[0051] (2) Add Engefi to the chitosan glue, then add physiological saline, shake well, adjust the pH value to 7.5 after defoaming, subpackage in bottles under a sterile environment, and irradiate with gamma rays Sterilize for 15 minutes to obtain a spray.

[0052] Wherein, the consumption of described chitosan mucilage, Engelfe and normal saline is as shown in Table 1.

[0053] The content of the chitosan mucilage in the thus prepared wound repair spray is 20wt%, and the content of the extract of the metabolites of Staphylococcus aureus is respectively 10wt%, 20wt%, 30wt%, 40wt% and 50wt%.

[0054] Table 1

[0055]

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Abstract

The invention provides a wound repair composition. A formula of the wound repair composition comprises the following components in percentage by weight: 10-50 percent of chitosan mucilage, 10-50 percent of an extracting solution of a staphylococcus aureus metabolic product and 0-80 percent of medicament auxiliary materials, wherein the chitosan mucilage is a solution consisting of chitosan and an aqueous solution of an acid; the volume concentration of the acid in the aqueous solution of the acid is 0.8-1.2 percent; and the mass concentration of the chitosan in the chitosan mucilage is 1-3 percent. The invention further provides a preparation method of the wound repair composition and an application thereof as a medicament for treating skin or mucosal injure. The wound repair composition provided by the invention has the advantages of capabilities of promoting tissue repair, promoting wound healing and promoting the growth of epidermal cells, good infection inhibiting effect, high biocompatibility, realization of flat healed wounds, freeness from adverse side reactions, relieving in patient pain, convenience for nursing and using, easiness for storing, and the like.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a wound repair composition and its preparation method and application. Background technique [0002] Wound repair is one of the most important and fundamental issues in the field of trauma surgery. Ulcers, moderate to severe bedsores, wounds, erosions, burns and other chronic and difficult-to-heal wounds will form various wounds, which will cause the body to lose its natural barrier, inhibit the immune function of the body, and cause other diseases. [0003] There are many factors that affect wound healing, such as infection, growth factors, local nutritional barriers, etc., and they are very complex. At present, there are drugs that promote wound healing through external application of antibacterial drugs and growth factors in China, such as Bactobang and Beifuji. However, these medicines are mostly powders, ointments, creams or injections, with poor uniformity, adhesion and target...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61K9/12A61K9/06A61K9/70A61P17/02A61P31/00A61L15/40A61L15/28A61L15/44A61K31/722
Inventor 汤春琳
Owner SHANGHAI RUNZHI BIOTECH
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