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Weight management composition

一种组合物、体重的技术，应用在药物组合、食物科学、植物原材料等方向，能够解决替代品不适口、脂肪不足以满足、缺乏获得食物费用和更多时间等问题

Pending Publication Date: 2020-12-22
ASERKIN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, similar to exercise, there are many barriers to eating healthy foods, such as lack of access to food, more expense and more time required to prepare food, and the fact that many healthy foods or meals are less palatable in comparison than unhealthy alternatives
Furthermore, even when weight loss is achieved through food and exercise, the amount of fat loss is often insufficient to meet the full weight loss an individual needs to maintain optimal health

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Example 1 Weight management composition improves body weight, fat mass and mitochondrial capacity in vivo.

[0093] According to one embodiment of the present invention, it is determined whether a weight management composition comprising a weight loss agent and a mitochondrial enhancing agent can: 1) reduce body weight and body fat, and improve mitochondrial capacity; and / or 2) enhance exercise-regulated body weight, body To improve lipid and mitochondrial capacity, mice fed a high-fat diet (HFD) were given a weight management composition or one of several control compositions and either exercised or sedentary for 30 days.

[0094] All experiments were approved by the McMaster University Animal Ethics Committee and performed in accordance with appropriate Canadian guidelines for animal research. Sixty C57 / B16 diet-induced obese mice were ordered from Jackson Laboratories, placed on a HFD (Teklad #TD.06414) containing 60% fat-derived energy at 6 weeks, and fed ad libitum...

Embodiment 2

[0102] An alternate form of the weight management composition of Example 2 improves body weight, body fat and mitochondrial capacity in vivo.

[0103] To demonstrate that an alternative embodiment of a weight management composition can similarly reduce body weight and body fat and increase mitochondrial capacity as observed in Example 1, a second study was performed in which HFD-fed mice were administered a compound containing 3 A single formulation of food weight management combined with exercise or no exercise (intermediate) for 1 month.

[0104]All experiments were approved by the McMaster University Animal Ethics Committee and performed in accordance with appropriate Canadian guidelines for animal research. Seventy-two C57 / B16 diet-induced obese mice were ordered from Jackson Laboratories, placed on HFD (Teklad #TD.06414) containing 60% fat energy at 6 weeks, and fed ad libitum. At approximately 12 weeks of age, mice were divided into experimental groups, which were norma...

Embodiment 3

[0119] Example 3 Alternative Forms of Weight Management Compositions Improve Body Fat Oxidation.

[0120] To assess some possible ways in which weight management compositions may reduce body weight or body fat to promote weight management, HFD-fed mice were placed in metabolic cages while being administered weight management compositions.

[0121]All experiments were approved by the McMaster University Animal Ethics Committee and performed in accordance with appropriate Canadian guidelines for animal research. Twenty-four C57 / B16 chow-induced obese mice were ordered from Jackson Laboratories and placed on a 60% fat-energy HFD (Teklad #TD.06414) at 6 weeks and fed ad libitum. At approximately 12 weeks of age, mice were divided into experimental groups, normalized to mean body weight, placed in metabolic cages (Columbus Laboratory Animal Monitoring System; Columbus Instruments), and allowed to acclimate to their new environment for approximately 12 weeks. Hour. After the accli...

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PUM

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Abstract

A method for promoting weight management in a mammal is provided, comprising administering to the mammal a composition comprising at least one weight loss agent and at least one mitochondria enhancingagent. The weight loss agent may be selected from the group consisting of psyllium, guar gum, capsaicin, chitosan, caffeine, garcinia cambogia, Pinus densiflora, capsaicin, yohimbre, hoodia, glucomannan, African mango, guarana, pyruvate, carnitine, beta-glucan, fucoxanthin, raspberry ketone, white kidney bean, kola nut, chromium, ginseng, psyllium, St. John's wort, dandelion, hydroxycitric acid,conjugated linoleic acid, green tea, black tea, green coffee beans extract, forskolin and bitter orange. The mitochondria enhancing agent may be selected from the group consisting of beetroot extract,nitrate, idebenone, nicotinamide riboside, elamepratide, vitamin C, vitamin D, vitamin E, thiamine, riboflavin, magnesium, calcium, phosphate, phospholipid, creatine, pyruvate, coenzyme Q10, NADH, nicotinic acid, L-camitine, dicholoracetate, curcumin, schisandrin and resveratrol. Compositions for weight management are also provided.

Description

technical field [0001] The present invention relates generally to compositions and methods for improving the health of an individual, and more particularly to compositions and methods for promoting weight management in an individual. Background technique [0002] The epidemic of overweight and obesity has become one of the most significant health problems facing the world. The incidence of obesity has almost tripled in the past 30 years, and globally, about 40% of adults over the age of 18 are now overweight and about 13% obese. The presence of obesity is known to be associated with the development of many other diseases such as fatty liver disease, cardiovascular disease, type 2 diabetes, hypertension, dyslipidemia, gallbladder disease, osteoarthritis, sleep apnea, asthma, chronic kidney disease and depression disease. Obesity is caused by an imbalance between an individual's total energy expenditure and energy intake. Therefore, these obesity-related comorbidities can b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K31/122A61K31/353A61K31/355A61K31/385A61K36/36A61K36/74A61P3/04C07C50/28C07D311/78C07D339/04
CPCA61K31/355A61K36/74A61K36/21A61K36/82A61K31/198A61P3/04A61K31/122A61K31/353A61K31/385A61K36/185A61K36/38A61K36/15A61K45/06A61K31/201A61K31/352A23L33/105A23L33/15A23L33/10A23L33/30A61K2300/00A61K31/197A61K36/61
Inventor 马克·塔诺波斯基
Owner ASERKIN CO LTD
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