Method and preparation for reducing irritation and/or inflammatory reaction in human skin

a technology of inflammatory reaction and skin irritation, which is applied in the field of preparation for reducing can solve the problems of considerable discomfort, irritation and/or inflammatory reaction, and complain of skin irritation, and achieve the effect of reducing the occurrence of irritation and/or inflammatory reaction in human skin

Inactive Publication Date: 2005-09-08
WIELAND EBERHARD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0017] It is therefore an object of the present invention to provide a method for

Problems solved by technology

Unfortunately, certain of these compounds may cause irritation and/or inflammatory reactions when they are topically applied onto the skin or mucous membranes.
However, administration of these derivatives presents a problem since they can cause stinging, itching and tautness after they have been applied, which may result in considerable discomfort.
It is also widely described that some users of cosmetic products comprising surfactants, preservatives, fragrances, solvents or propellants complain that their skin is irritated after applying one or more of the above substrates thereto.
However, because of their irritant nature, these products are generally employed at very low doses.
Formulation of these products in small amounts may, therefore, prove to be relatively disadvantageous with respect to administration of other active species which are less active, but which are formulated in greater amounts since they are less or not irritant.
It is also known to this a

Method used

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  • Method and preparation for reducing irritation and/or inflammatory reaction in human skin
  • Method and preparation for reducing irritation and/or inflammatory reaction in human skin
  • Method and preparation for reducing irritation and/or inflammatory reaction in human skin

Examples

Experimental program
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Effect test

example 1

Retinoid Irritation

[0067] In a test, idebenone was applied to the facial skin of humans. Two different test sites were setup whereby, one site was applied with idebenone twice a day for 2 weeks followed by a 2 week application period of a prescription retinoid (once a day, as prescribed). The remaining site was applied for 2 weeks just the prescription retinoid (once a day, as prescribed). Each test site was evaluated by a trained clinician for irritation and roughness using a 0 (none) to 4 (severe) scale pre and post retinoid treatment. Additionally, transepidermal water loss measurements (TEWL) were also made at the same time as visual evaluations. At the end of the treatment period, the site treated only with the prescription retinoid exhibited significant increases in TEWL, irritation and roughness compared to a moderate to minimal increase in the same parameters measured when the site was treated with Idebenone for 2 weeks prior to retinoid applications.

[0068]FIG. 1 graphical...

example 2

Methyl Gentisate / Glycolic Acid Irritation

[0070] In another test, idebenone was applied to the backs of humans. Approximately 0.2 ml of a two formulas, one containing Methyl Gentisate and Glycolic Acid and the other the same combination of Methyl Gentisate and Glycolic Acid with 0.5% idebenone. Both were applied to a 2 cm×2 cm square of Webril cotton fabric (affixed to Scanpor semi-occlusive surgical tape) and placed on the back of each subject between the scapulae and waist, adjacent to the spinal mid-line. Patches were removed 24 hours after each application and the test site was allowed to rest for an additional 24 hours prior to repatching. All test sites were graded for erythema and edema prior to reapplication of the next patch. Patch testing was stopped upon the development of moderate irritation at the test sites. The combination of Methyl Gentisate and Glycolic Acid alone produced moderate irritation with edema after 1 patch in 4 out 100 subjects, whereas the combination of...

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Abstract

A method for reducing an occurrence of irritation and/or inflammatory reaction in human skin includes applying a topical preparation to the skin. The preparation includes an amount of an agent effective to reduce an occurrence of irritation and/or inflammatory reaction in human skin. The agent includes idebenone or a derivative of idebenone.

Description

[0001] Priority is claimed to provisional application 60 / 544,359, filed Feb. 13, 2004.[0002] The present invention in general relates to human skin, and in particular relates to reduction of irritation and / or inflammatory reaction in human skin. BACKGROUND [0003] A wide variety of compounds are formulated into cosmetics to, inter alia, improve the appearance of the skin, to beautify the skin, to treat skin conditions, or to render the skin less dry or more supple. Unfortunately, certain of these compounds may cause irritation and / or inflammatory reactions when they are topically applied onto the skin or mucous membranes. [0004] It is known to this art to administer salicylic acid derivatives as keratolytic agents for treating acne; these are also useful anti-aging agents in cosmetic and / or dermatological compositions. Thus, FR-A-2,581,542 and EP-A-378,936 describe such salicylic acid compounds. [0005] Salicylic acid derivatives are of great value, given their biological effects on t...

Claims

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Application Information

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IPC IPC(8): A61K31/12
CPCA61K8/355A61K31/12A61Q19/005A61K2800/75A61K31/122A61P29/00
Inventor DINARDO, JOSEPH C.LEWIS, JOSEPH A. IINEUDECKER, BIRGITDIEDRICH, FALKOWIELAND, EBERHARD
Owner WIELAND EBERHARD
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