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Idebenone-embedded nanolipid carrier as well as preparation method and application thereof

A technology of nano-lipid carrier and lecithin, which is applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of few nano-structured lipid carriers and no reports, etc. The effect of high volume, good skin absorption and high entrapment rate

Inactive Publication Date: 2020-06-09
上海格兰化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are relatively few studies on nanostructured lipid carriers, and the research on coating idebenone with nanostructured liposomes has not been reported.

Method used

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  • Idebenone-embedded nanolipid carrier as well as preparation method and application thereof
  • Idebenone-embedded nanolipid carrier as well as preparation method and application thereof
  • Idebenone-embedded nanolipid carrier as well as preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0049] The invention provides the preparation method of the nano-lipid carrier embedding idebenone, comprising the following steps:

[0050] (1) mixing and heating Hawaiian soybean oil, palm wax and idebenone to obtain an oil phase;

[0051] (2) mixing and heating water, polyhydric alcohol, surfactant and lecithin to obtain an aqueous phase;

[0052] (3) adding the oil phase to the water phase to obtain a mixed phase;

[0053] (4) Pre-emulsify and high-pressure homogenize the mixed phase successively to obtain a nano-lipid carrier embedding idebenone;

[0054] The steps (1) and (2) are not limited by time sequence.

[0055] The invention mixes and heats macadamia oil, palm wax and idebenone to obtain an oil phase. In the present invention, the heating temperature is preferably 85-90°C. In the present invention, the macadamia soybean oil and palm wax are preferably mixed and heated to the desired temperature, and then idebenone is added therein for mixing. The present inve...

Embodiment 1

[0063] A nano-lipid carrier for embedding idebenone, each component and the corresponding mass percentage are shown in Table 1, and are prepared by the following steps:

[0064] (1) heating macadamia soybean oil and palm wax to 90°C at a constant temperature, then adding idebenone to it, and macadamia soybean oil, palm wax and idebenone are all dissolved to obtain an oil phase;

[0065] (2) Heat water, 1,2-pentanediol, surfactant and soybean lecithin to 90°C at a constant temperature, dissolve all of them, and obtain an aqueous phase;

[0066] (3) Add the oil phase to the water phase, and keep the temperature at 90°C to obtain a mixed phase;

[0067] (4) Utilize the emulsifier to pre-emulsify the mixed phase. The rotating speed of the emulsifier is 8000rpm, and the time of pre-emulsification is 5min; The operating pressure was 700 bar, and after 5 cycles, it was naturally cooled to room temperature to obtain a nano-lipid carrier embedded with idebenone.

Embodiment 2～9

[0069] A nano-lipid carrier embedded with idebenone is different from Example 1 in that the components and their corresponding mass percentages are shown in Table 1.

[0070] Each component and corresponding mass percent content in table 1 embodiment 1~9

[0071]

[0072]

[0073] The particle size, interface potential, crystallinity and embedding rate of the idebenne-embedded nano-lipid carriers (NO.1-NO.9) prepared in Examples 1-9 were tested:

[0074] (1) Particle size detection

[0075] The size and distribution of particle size are very important to the stability of the system. Table 2 shows the average particle size data of idebenne-embedded nano lipid carriers (NO.1-NO.9) stored for 1-56 days. It can be seen from Table 2 that the average particle size of the prepared idebenne-embedded nano-lipid carrier is between 161nm and 919nm after storage for 1 day, and the change in particle size is relatively stable after 56 days.

[0076] Table 2 Average particle size da...

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Abstract

The invention provides an idebenone-embedded nanolipid carrier as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The nanolipid carrier providedby the invention includes the following components in percentages by mass: 10-30% of macadamia nut oil, 5-15% of palm wax, 1-5% of idebenone, 6-10% of a surfactant, 1-5% of polyol, 0.5-1.5% of lecithin, and the balance of water. According to the carrier, the macadamia nut oil, the palm wax, the surfactant, the polyol and the lecithin are used together to coat the idebenone, so that the provided idebenone-embedded nanolipid carrier has the advantages of good stability, a high embedding rate, a high drug loading amount and good skin absorption, and can be well applied in cosmetics. The inventionprovides a preparation method of the idebenone-embedded nanolipid carrier. The preparation method provided by the invention adopts a heat high-pressure homogenization technology, and can effectivelyrealize the stable embedding of the idebenone by the nano-lipid carrier.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a nano-lipid carrier for embedding idebenone and its preparation method and application. Background technique [0002] With the advancement of society and the continuous improvement of living standards, people pay more and more attention to skin care and care. There are countless skin care products on the market. Skin care products are rich in active ingredients, which can achieve repairing, moisturizing or moisturizing functions. Idebenone is a fat-soluble orange substance, a new generation of antioxidant, which has been used in some skin care products in recent years. The anti-oxidation effect of idebenol surpasses L-C, vitamin A, vitamin E and coenzyme Q10, and it has become one of the popular ingredients in anti-aging skin care products. [0003] How to slow down the release of active ingredients in skin care products, avoid instability and ensure that they can be delivere...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/14A61K8/34A61K8/35A61K8/55A61Q19/00A61Q19/08
CPCA61K8/553A61K8/922A61K8/345A61K8/355A61K8/14A61Q19/08A61Q19/00A61K2800/56
Inventor 陈宝祺庞文心潘颀钧李秋涛
Owner 上海格兰化妆品有限公司
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