The invention discloses a high-protein high-yield feed for river crabs. The high-protein high-yield feed is prepared from the following raw materials: rapeseed dregs, cottonseed dregs, distiller grains, corn flour, bran, handmade noodles, sweet potato flour, soy bean meal, alpha-starch, wheat middling, dried bean curd stick powder, white fish meal, silkworm chrysalis meal, inkfish paste, yellow mealworm powder, neural alfalfa powder, water barnyardgrass, herb of rice galingale, seaweed meal, zeolite powder, monocalcium phosphate, bentonite, vegetable oil, whey powder, saccharicterpenin, manno-oligosaccharides, allicin, glycine betaine, glucose sorbic acid, polyvinylpyrrolidone, multi-vitamins, compound amino acid, compound mineral elements, complex enzyme, a compound microbe additive, a non-protein nitrogen compound supplement, propyl gallate, a phagostimulant, sodium sorbate, sodium glutamate and sodium alginate. After being used for culturing river crabs, the feed is capable of effectively improving the yield and quality of the river crabs.