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Method for preparing alginate microsphere/high polymer composite nanometer fiber by electrostatic spinning

A composite nanofiber and alginate technology, applied in wet spinning, fiber chemical characteristics, rayon manufacturing, etc., to achieve good economic benefits, broad application prospects, and simple operation

Inactive Publication Date: 2009-10-14
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Theoretically, as long as any polymer can find a suitable solvent system, it is possible to electrospun into nanofibers, which has the possibility of mass production

Method used

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  • Method for preparing alginate microsphere/high polymer composite nanometer fiber by electrostatic spinning
  • Method for preparing alginate microsphere/high polymer composite nanometer fiber by electrostatic spinning
  • Method for preparing alginate microsphere/high polymer composite nanometer fiber by electrostatic spinning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]Weigh 0.1g of sodium alginate with a balance and dissolve it in 10mL of ultrapure water, stir and oscillate to dissolve completely to obtain sodium alginate hydrogel; under stirring conditions, add 1mL of sodium alginate hydrogel drop by drop Add 0.05g SPAN-80 in 10ml of dichloromethane solution; then add 0.5ml of 5% calcium chloride solution by mass fraction, then continue to stir until a uniform and stable emulsion is formed; finally add 0.8g poly(lactic acid-caprolactone )P(LLA-CL)[75:25], continue stirring until the polymer is completely dissolved in the solution. Electrospinning was performed on the obtained solution, the applied voltage was 20kv, the receiving distance was 15cm, the spinning speed was 1.0mL / h, and the diameter of the spinneret was 0.9mm. The diameter of the obtained nanofiber is between 500nm and 1500nm, and the diameter of the microsphere attached to the fiber is between 1000nm and 3000nm.

Embodiment 2

[0032] Weigh 0.05g potassium alginate with a balance and dissolve it in 5mL ultrapure water, stir and oscillate to dissolve completely to obtain alginate hydrogel; under stirring conditions, add 0.8mL alginate hydrogel drop by drop Add 0.05g SPAN-80 into 10ml of dichloromethane solution; then add 0.4ml of 5% calcium chloride solution by mass fraction, then continue to stir until a uniform and stable emulsion is formed; finally add 0.7g poly(lactic acid-caprolactone Ester) P(LLA-CL)[75:25], continue to stir until the polymer is completely dissolved in the solution. Electrospinning was performed on the obtained solution, the applied voltage was 16kv, the receiving distance was 16cm, the spinning speed was 1.2mL / h, and the diameter of the spinneret was 0.9mm. The diameter of the obtained nanofiber is between 500nm and 1500nm, and the diameter of the microsphere attached to the fiber is between 1000nm and 3000nm.

Embodiment 3

[0034] Weigh 0.07g sodium alginate with a balance and dissolve it in 7mL ultrapure water, stir and oscillate to dissolve completely to obtain sodium alginate hydrogel; under stirring conditions, add 0.4mL sodium alginate hydrogel dropwise Add 0.02g Tween-80 into 5ml of chloroform solution; then add 0.2ml of 5% calcium chloride solution by mass fraction, then continue to stir until a uniform and stable emulsion is formed; finally add 0.35g poly(lactic acid-hexyl Ester) P(LLA-CL)[50:50], continue to stir until the polymer is completely dissolved in the solution. The obtained solution was electrospun with an applied voltage of 18kv, a receiving distance of 19cm, a spinning speed of 1.1mL / h, and a spinneret diameter of 0.9mm. The diameter of the obtained nanofiber is between 500nm and 1500nm, and the diameter of the microsphere attached to the fiber is between 1000nm and 3000nm.

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Abstract

The invention relates to a method for preparing an alginate microsphere / high polymer composite nanometer fiber by electrostatic spinning. The method comprises the following steps of: dissolving alginate or alginate blend in distilled water or super purified water to obtain uniform alginate aquagel and water phase solution A; evenly mixing a surface activate agent and an organic solvent to obtain oil phase solution B; mixing the water phase solution A and the oil phase solution B according to a volume ratio of 1:10-15 with the addition of 0.1 to 0.5ml of calcium chloride solution, and shaking and evenly mixing the mixture to obtain mixed solution; adding a high polymer spinning material into the mixed solution for electrostatic spinning to obtain the alginate microsphere / high polymer composite nanometer fiber. The preparation method has simple operation and excellent economic benefit, is friendly to environment and is applicable to large-scale production; and the method combines the microsphere into the nanometer fiber, so that the prepared fiber performs excellence in both mechanical performance and slow release property compared with common electrospun fibers and has wider application prospect.

Description

technical field [0001] The invention belongs to the field of preparation of polymer composite nanofibers, in particular to a method for preparing alginate microsphere / high polymer composite nanofibers by electrospinning. Background technique [0002] Alginic acid is a natural polysaccharide mainly derived from marine plants, namely Chlorophyceae, Cyanophyceae, Rhodophyceae and Phaeophyceae. In addition, alginic acid can also be extracted from nitrogen-fixing bacteria and pseudomonas, and this type of product is also called bacterial alginic acid. [0003] The chemical composition of alginic acid is very simple, consisting of β-D-mannuronic acid (referred to as M unit) and α-L-guluronic acid (referred to as G unit) connected by 1,4-glycosidic bonds. Because the following three situations will appear during the connection process, that is, the MG of a single MMM or GGG and MGGGMM is mixed and alternated. The different ratios of G units and M units in the molecule determine i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/92D01F1/10D01D5/06
Inventor 莫秀梅周叙李晓强苏艳高蔡玖
Owner DONGHUA UNIV
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