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A stent sleeve for treating intravascular injury and bleeding and preparation method thereof

A technology of injury bleeding and stent sleeves, which is applied in the fields of polymer materials and biomedical engineering, can solve the problems of vascular repair, inability to treat intravascular bleeding injuries, and incomplete degradation of magnesium alloys.

Active Publication Date: 2021-09-14
SHANDONG RIENTECH MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The Chinese invention patent application with the publication number CN102908673A discloses a stent coating with hemostatic and antibacterial functions. The stent coating is a mixed solution composed of organic polymer materials, drug molecules, and microspheres containing antibacterial drugs. Made by spinning technology; the main function of the stent coating is to sterilize and stop bleeding, and has no effect on promoting the healing of endothelial tissue, and the microspheres have the disadvantage of low drug loading, so they cannot be used to treat intravascular hemorrhage injuries
[0006] The Chinese invention patent application with publication number CN103948453A discloses a degradable magnesium alloy covered stent graft and a covered stent system. Consistent, it will cause blood vessel repair, but the magnesium alloy is not completely degraded; or the magnesium alloy has been completely degraded, but the blood vessel is not completely repaired, resulting in a greatly reduced therapeutic effect
In addition, if the degradation products of magnesium alloy cannot be absorbed by the human body in time, it will affect the recovery of tissue function and may have adverse reactions to the human body.

Method used

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  • A stent sleeve for treating intravascular injury and bleeding and preparation method thereof
  • A stent sleeve for treating intravascular injury and bleeding and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: Polyester stent cover

[0044] 1. Preparation of growth factor suspension: take 100 mg of nano-sized growth factors and place them in 4 mL of absolute ethanol, and prepare growth factor suspensions by ultrasonic dispersion;

[0045] 2. Synthesis of flexible and degradable copolymers: 1,4-butanediol was used as the initiator, stannous octoate was used as the catalyst, and ε-caprolactone and lactide were characterized by ring-opening polymerization at a ratio of 50 / 50 (mol / mol) A copolymer with a viscosity number of 1.0dL / g;

[0046] 3. Preparation of co-solvent solution: Weigh 1.0g of the above-mentioned copolymer, dissolve it in a blend solution of N,N dimethylformamide and tetrahydrofuran to prepare a 40% concentration of co-solvent solution, in which N,N dimethylformamide The volume ratio with tetrahydrofuran is 1:1;

[0047] 4. Preparation of a stent sleeve for treating intravascular injury and bleeding

[0048] Take 1mL of growth factor solution, mi...

Embodiment 2

[0054] Example 2: Polyester stent cover

[0055] 1. Preparation of growth factor suspension: take 100 mg of nano-sized growth factors and place them in 5 mL of absolute ethanol, and prepare growth factor suspensions by ultrasonic dispersion;

[0056] 2. Synthesis of flexible and degradable copolymers: 1,4-butanediol was used as the initiator, stannous octoate was used as the catalyst, and ε-caprolactone and lactide were characterized by ring-opening polymerization at a ratio of 40 / 60 (mol / mol) A copolymer with a viscosity number of 1.2dL / g;

[0057] 3. Preparation of co-solvent solution: Weigh 1.0g of the above-mentioned copolymer, dissolve it in a blend solution of N,N dimethylformamide and tetrahydrofuran to prepare a 45% concentration of co-solvent solution, in which N,N dimethylformamide The volume ratio with tetrahydrofuran is 3:1;

[0058] 4. Preparation of a stent sleeve for treating intravascular injury and bleeding

[0059] Take 1mL of growth factor solution, mi...

Embodiment 3

[0065] Embodiment 3: Polyester stent cover

[0066] 1. Preparation of growth factor suspension: take 100 mg of nano-sized growth factors and place them in 5 mL of absolute ethanol, and prepare growth factor suspensions by ultrasonic dispersion;

[0067] 2. Synthesis of flexible and degradable copolymers: 1,4-butanediol was used as the initiator, stannous octoate was used as the catalyst, and ε-caprolactone and lactide were characterized by ring-opening polymerization at a ratio of 80 / 20 (mol / mol) A copolymer with a viscosity number of 1.2dL / g;

[0068] 3. Preparation of co-solvent solution: Weigh 1.0g of the above-mentioned copolymer, dissolve it in the blend solution of N,N dimethylformamide and tetrahydrofuran to prepare a solution with a concentration of 50%, in which N,N dimethylformamide and tetrahydrofuran The volume ratio is 1:3;

[0069] 4. Preparation of a stent sleeve for treating intravascular injury and bleeding

[0070] Take 1mL of growth factor solution, mi...

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Abstract

The invention discloses a stent sleeve for treating injury and bleeding in a blood vessel cavity and a preparation method thereof. The stent cover utilizes the degradability of polylactide, and uses the polylactide as a degradable basic stent to obtain a stent cover for treating intravascular injury and bleeding. A developing belt is arranged in the middle of the outer surface of the stent cover, which is convenient for determining the release position of the stent cover, and ensures that the bleeding site is covered after the stent cover is released. At the same time, the development belt is located in the middle position so that the development belt is not easy to fall off during the transportation process; the surface of the stent sleeve contains growth factors, which can slowly release the growth factors, effectively block the damaged blood vessels, and at the same time promote the tissue at the damaged site to the greatest extent. heal. The stent sleeve provided by the present invention has good biocompatibility, does not cause thrombus or inflammation after being implanted in blood vessels, is easy to operate, can be implanted without special equipment, and has high drug loading capacity, Good hemostatic effect and other advantages.

Description

technical field [0001] The invention relates to the technical fields of macromolecule materials and biomedical engineering, in particular to a stent sleeve for treating intravascular injury and bleeding and a preparation method thereof. Background technique [0002] With the development of medical technology, endovascular treatment of stents is widely used in various clinical fields. However, the incidence of iatrogenic injuries caused by various reasons also increases during stent implantation, and even injuries to large blood vessels are not uncommon. For example, in the process of stent implantation, the arterial wall is weak, the stenosis often spreads to the lenticulostriate artery, and the plaque shape is complex. During the implantation process, the stent can easily cause rupture and bleeding of the target vessel and side branch arteries. The iatrogenic injury caused by the guide wire and catheter penetrating the large artery can also lead to massive bleeding in a sh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/18A61L31/14A61L31/10A61L31/16
CPCA61L31/10A61L31/14A61L31/16A61L31/18A61L2300/414A61L2300/602A61L2400/04C08L67/04C08L89/00C08L77/00C08L69/00
Inventor 张海军葛均波鲁手涛尹玉霞侯文博周超段翠海刘光
Owner SHANDONG RIENTECH MEDICAL TECH
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