A stent sleeve for treating intravascular injury and bleeding and preparation method thereof

Abstract

The invention discloses a stent sleeve for treating injury and bleeding in a blood vessel cavity and a preparation method thereof. The stent cover utilizes the degradability of polylactide, and uses the polylactide as a degradable basic stent to obtain a stent cover for treating intravascular injury and bleeding. A developing belt is arranged in the middle of the outer surface of the stent cover, which is convenient for determining the release position of the stent cover, and ensures that the bleeding site is covered after the stent cover is released. At the same time, the development belt is located in the middle position so that the development belt is not easy to fall off during the transportation process; the surface of the stent sleeve contains growth factors, which can slowly release the growth factors, effectively block the damaged blood vessels, and at the same time promote the tissue at the damaged site to the greatest extent. heal. The stent sleeve provided by the present invention has good biocompatibility, does not cause thrombus or inflammation after being implanted in blood vessels, is easy to operate, can be implanted without special equipment, and has high drug loading capacity, Good hemostatic effect and other advantages.

Description

technical field [0001] The invention relates to the technical fields of macromolecule materials and biomedical engineering, in particular to a stent sleeve for treating intravascular injury and bleeding and a preparation method thereof. Background technique [0002] With the development of medical technology, endovascular treatment of stents is widely used in various clinical fields. However, the incidence of iatrogenic injuries caused by various reasons also increases during stent implantation, and even injuries to large blood vessels are not uncommon. For example, in the process of stent implantation, the arterial wall is weak, the stenosis often spreads to the lenticulostriate artery, and the plaque shape is complex. During the implantation process, the stent can easily cause rupture and bleeding of the target vessel and side branch arteries. The iatrogenic injury caused by the guide wire and catheter penetrating the large artery can also lead to massive bleeding in a sh...

AI Technical Summary

Problems solved by technology

[0005] The Chinese invention patent application with the publication number CN102908673A discloses a stent coating with hemostatic and antibacterial functions. The stent coating is a mixed solution composed of organic polymer materials, drug molecules, and microspheres containing antibacterial drugs. Made by spinning technology; the main function of the stent coating is to sterilize and stop bleeding, and has no effect on promoting the healing of endothelial tissue, and the microspheres have the disadvantage of low drug loading, so they cannot be used to treat intravascular hemorrhage injuries

[0006] The Chinese invention patent application with publication number CN103948453A discloses a degradable magnesium alloy covered stent graft and a covered stent system. Consistent, it will cause blood vessel repair, but the magnesium alloy is not completely degraded; or the magnesium alloy has been completely degraded, but the blood vessel is not completely repaired, resulting in a greatly reduced therapeutic effect

In addition, if the degradation products of magnesium alloy cannot be absorbed by the human body in time, it will affect the recovery of tissue function and may have adverse reactions to the human body.

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