The application relates to the fields of
biological information processing,
computational biology and
intelligent computing technology, and discloses a candidate intervention generation method and
system based on multi-
modal biological data unified representation and structural anomaly inversion. The method acquires multi-
modal biological data of a target object, wherein the multi-
modal biological data comprises at least two types of
genomic data, transcriptomic data,
protein interaction data, metabolomic data and
phenotype data; the multi-modal biological data is subjected to
standardization processing and modality alignment, and a unified
structural representation is constructed; based on the unified
structural representation, a structural anomaly index of the target object relative to a reference steady-state object is calculated, and an abnormal
structural representation unit is determined, or a target structural constraint set is extracted based on a target functional state, a target
spatial configuration or a target structure input; a candidate intervention structure or a candidate functional structure output object is generated based on the abnormal structural representation unit or the target structural constraint set; consistency
verification, error correction, constraint compliance checking, scoring and sorting are performed on the candidate result through a multi-scale audit module, and the candidate result is output. The application can realize unified fusion of multi-modal biological data,
system-level
abnormal structure positioning, target-driven reverse generation and multi-scale audit
verification, reduce the candidate search space, and improve the explainability, reproducibility and priority sorting efficiency of the candidate output.