Application of Flabelliferin B in preparing anti-tuberculosis drugs

An anti-tuberculosis and tuberculosis technology, applied in antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc. Strong inhibitory activity, outstanding substantive features, and wide variety of effects

Inactive Publication Date: 2016-04-06
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. great difficulty at work

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Flabelliferin B in preparing anti-tuberculosis drugs
  • Application of Flabelliferin B in preparing anti-tuberculosis drugs
  • Application of Flabelliferin B in preparing anti-tuberculosis drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: the preparation of the compound Flabelliferin B tablet involved in the present invention:

[0020] Take 5 grams of compound Flabelliferin B, add 195 grams of dextrin, mix well, and make 1000 tablets with a conventional tablet machine.

Embodiment 2

[0021] Embodiment 2: the preparation of compound Flabelliferin B capsules involved in the present invention:

[0022] Take 5 grams of the compound Flabelliferin B, add 195 grams of starch, mix well, and make 1000 capsules.

[0023] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0024] Experimental Example 1 Solid Medium Dilution Method Determination of FlabelliferinB Anti-Bacillus Calmette-Guerin (BCG) Absolute Concentration

[0025] Scrape the BCG culture from the inclined surface, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1). Turbidity, that is to make 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension. Flabelliferin B is made into a high-concentration stock solution with DMSO, and the stock solution is diluted to the required concentration with 5% Tween-80 sterile ultrapure water, and the diluted Flabelliferin B is added to 4ml Middlebrook7H11 agar medium according to the required dose (the culture Base has been sterilized by high-pressure steam at 121°C for 15 minutes, cooled to 50-55°C), mixed evenly, and made to contain Flabelliferin B, the conc...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses application of Flabelliferin B in preparing anti-tuberculosis drugs. The invention, in accordance with the current situation that the morbidity and mortality of tuberculosis are on the rise due to the high morbidity of the tuberculosis and the appearance multiple drug-resistant strains of the tuberculosis at present, discovers that the Flabelliferin B has an activity of significantly inhibiting tuberculosis, and the Flabelliferin B is good in application prospect. The invention discovers the application of the Flabelliferin B in preparing anti-tuberculosis drugs firstly; a completely new skeleton type is adopted and the activity on inhibiting the tuberculosis is extraordinarily strong, and the invention is impossible to be inspired by other compounds in any forms, therefore outstanding substantive features are achieved; and meanwhile, on the prevention and treatment of tuberculous infection, a significant progress is obviously made.

Description

technical field [0001] The present invention relates to a new application of the compound Flabelliferin B, in particular to the application of the Flabelliferin B in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. According to the World Health Organization (WHO) estimates, the population infected by Mycobacterium tuberculosis (MTB) accounts for one-third of the world's population, and 5-10% of them are infected. become tuberculosis patients. There are 1.3 million cases of active tuberculosis patients in my country every year, including about 600,000 cases of infectious tuberculosis, and about 600,000 cases of infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P31/06
CPCA61K31/56A61K9/2059A61K9/4866
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap