Application of compound in preparation of medicaments for resisting tubercle bacillus

An anti-tuberculosis and compound technology, applied in antibacterial drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as difficulties in tuberculosis prevention and treatment, and non-standard treatment and management of tuberculosis patients, and achieve tuberculosis suppression The effect of strong activity, outstanding substantive features, and broad application prospects

Inactive Publication Date: 2013-09-11
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. great difficulty at work

Method used

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  • Application of compound in preparation of medicaments for resisting tubercle bacillus
  • Application of compound in preparation of medicaments for resisting tubercle bacillus
  • Application of compound in preparation of medicaments for resisting tubercle bacillus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of compound Aspeverin tablet involved in the present invention:

[0017] Get 20 grams of compound Aspeverin, add 180 grams of conventional adjuvants for tablet preparation, mix well, and make 1000 tablets with a conventional tabletting machine.

Embodiment 2

[0018] Embodiment 2: the preparation of compound Aspeverin capsules involved in the present invention:

[0019] Get 20 grams of compound Aspeverin, add conventional auxiliary materials for preparing capsules, such as 180 grams of starch, mix well, and make 1000 capsules.

experiment example 1

[0020] Experimental Example 1 Determination of the Absolute Concentration of Aspeverin Against Bacillus Calmette-Guerin (BCG) by the Solid Medium Dilution Method

[0021] Scrape the BCG culture from the slant, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1) Turbidity, that is, to prepare 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0022] Aspeverin was made into a high-concentration stock solution with DMSO, and the stock solution was diluted to the required concentration with 5% Tween-80 sterile ultrapure water, and the diluted Aspeverin was added to 4ml Middlebrook7H11 agar medium according to the required dose (the The medium has been sterilized by high-pressure steam at 121°C for 15 minutes, cooled to 50-55°C), mixed evenly, and made to contain Aspeverin, the concentr...

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PUM

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Abstract

The invention discloses an application of Aspeverin in preparation of medicaments for resisting tubercle bacillus. According to the application disclosed by the invention, Aspeverin is found to have an activity of remarkably inhibiting tubercle bacillus, and a great application prospect, aiming at the current situations that the morbidity and mortality of tuberculosis are on the rise due to the high morbidity of tuberculosis and the occurrence of multi-drug-resistant mycobacterium tuberculosis strains at present. The application of the Aspeverin in preparation of medicaments for resisting tubercle bacillus is disclosed for the first time; the Aspeverin has a new framework type, and an unexpectedly high inhibition activity on tubercle bacillus, so that the possibility of giving any revelation by other compounds is avoided; and the Aspeverin has prominent substantive features, and an obviously remarkable improvement in case of being used for preventing and treating tubercle bacillus infection.

Description

technical field [0001] The invention relates to a new application of compound Aspeverin, in particular to the application of Aspeverin in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. According to the World Health Organization (WHO) estimates, the population infected by Mycobacterium tuberculosis (MTB) accounts for one-third of the world's population, of which 5-10% Infected people become TB patients. There are 1.3 million cases of active tuberculosis patients in my country every year, including about 600,000 cases of infectious tuberculosis, and about 600,000 cases of infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the irregular treatment and management...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/537A61P31/06
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH
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