Application of quinine compound in preparing anti-tubercle bacillus drugs

An anti-tuberculosis and compound technology, applied in antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of difficult tuberculosis prevention and control, and the treatment and management of tuberculosis patients is not very standardized, and achieves the expansion of types, The effect of broad application prospects

Inactive Publication Date: 2010-10-20
SUN YAT SEN UNIV
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Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more s

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  • Application of quinine compound in preparing anti-tubercle bacillus drugs
  • Application of quinine compound in preparing anti-tubercle bacillus drugs
  • Application of quinine compound in preparing anti-tubercle bacillus drugs

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Abstract

The invention discloses an application of a quinine compound in preparing anti-tubercle bacillus drugs. A structure general formula of the quinine compound of the invention is shown in a formula (1), wherein R is H or OH. In the invention, aiming to current situations that the current tuberculosis has high morbidity, and multidrug-resistant tuberculosis (TB) strains of tubercle bacillus occur so that the morbidity and mortality of the tuberculosis are in a rising trend, and according to characteristics of anti-tubercle bacillus and tolerance tubercle bacillus activities of the quinine compound, the quinine compound is used for preparing the anti-tubercle bacillus drugs. The quinine compound of the invention is derived from marine microorganisms, is easy to be extracted, has low cost and wide application prospect, and can be used for preparing the anti-tubercle bacillus drugs.

Description

technical field The invention relates to the application field of pharmaceutical compounds, in particular to the application of quinone compounds in the preparation of anti-tuberculosis drugs. Background technique Since the discovery of cephalosporins from marine fungi in the 1960s, metabolites of marine microorganisms have increasingly become a rich source of drugs. According to Professor John's report in "Natural Product Reports" in 1010, more than 1,000 new compounds of marine natural products were discovered for the first time in 2008, and marine microorganisms were one of the main sources (accounting for about 23%). Due to the special environment of marine microorganisms, they can metabolize compounds with novel structures and have good pharmacological activities. A large number of active compounds such as anti-tumor, treatment of cardiovascular diseases, and immunomodulators have been discovered. In addition, marine microorganisms are easy to collect and cultivate, a...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P31/06
Inventor 佘志刚赖小敏林永成陈省平黄宇虹陈洪陈伊
Owner SUN YAT SEN UNIV
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