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The pplication of Polyflavanostilbene A in preparing an anti-tubercle bacillus medicine

An anti-tuberculosis and drug technology, applied in the field of compounds, can solve the problems of difficulty in tuberculosis prevention and control, and the treatment and management of tuberculosis patients is not very standardized, and achieves the effects of strong tuberculosis inhibitory activity, prominent substantive characteristics, and broad application prospects.

Inactive Publication Date: 2013-09-11
李正梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. great difficulty at work

Method used

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  • The pplication of Polyflavanostilbene A in preparing an anti-tubercle bacillus medicine
  • The pplication of Polyflavanostilbene A in preparing an anti-tubercle bacillus medicine
  • The pplication of Polyflavanostilbene A in preparing an anti-tubercle bacillus medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of the compound Polyflavanostilbene A tablet involved in the present invention:

[0016] Take 5 grams of compound Polyflavanostilbene A, add 195 grams of dextrin, mix well, and make 1000 tablets with a conventional tablet machine.

Embodiment 2

[0017] Embodiment 2: the preparation of the compound Polyflavanostilbene A capsules involved in the present invention:

[0018] Get 5 grams of compound Polyflavanostilbene A, add 195 grams of starch, mix well, pack into capsules and make 1000 capsules. Experimental Example 1 Determination of Absolute Concentration of Polyflavanostilbene A Anti-Bacillus Calmette-Guerin (BCG) by Solid Medium Dilution Method

experiment example 1

[0018] Get 5 grams of compound Polyflavanostilbene A, add 195 grams of starch, mix well, pack into capsules and make 1000 capsules. Experimental Example 1 Determination of Absolute Concentration of Polyflavanostilbene A Anti-Bacillus Calmette-Guerin (BCG) by Solid Medium Dilution Method

[0019] Scrape the BCG culture from the slant, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1) Turbidity, that is, to prepare 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0020] Make Polyflavanostilbene A into a high-concentration stock solution with DMSO, dilute the stock solution to the required concentration with 5% Tween-80 sterile ultrapure water, and add the diluted Polyflavanostilbene A to 4ml Middlebrook7H11 agar medium according to the required dose ( The medium has been sterili...

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Abstract

The invention discloses the applications of Polyflavanostilbene A in preparing an anti-tubercle bacillus medicine. Aimed at the current situation that the morbidity and mortality of tuberculosis are on the rise due to the high morbidity of tuberculosis and the appearance of multi-drug resistant strain of mycobacterium tuberculosis at present, the invention discovers that Polyflavanostilbene A has obvious activity in suppressing tubercle bacillus, and has good application prospects. The application of Polyflavanostilbene A in preparing an anti-tubercle bacillus medicine is disclosed for the first time; and since the skeleton type is a brand new one and the activity in suppressing tubercle bacillus is unexpectedly high, the possibility of any prompt given by other compounds does not exist, and prominent substantive features are provided and a remarkable progress in preventing and treating tubercle bacillus infection.

Description

technical field [0001] The present invention relates to a new application of compound Polyflavanostilbene A, in particular to the application of Polyflavanostilbene A in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. According to the World Health Organization (WHO) estimates, the population infected by Mycobacterium tuberculosis (MTB) accounts for one-third of the world's population, of which 5-10% Infected people become TB patients. There are 1.3 million cases of active tuberculosis patients in my country every year, including about 600,000 cases of infectious tuberculosis, and about 600,000 cases of infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the ir...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P31/06
Inventor 不公告发明人
Owner 李正梅
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