External applied preparation for etodolac

A technology of etodolac and external preparations, applied in the new field of pharmaceutical preparations

Active Publication Date: 2008-02-13
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no other dosage form clinically at present, and the inventi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] etodolac common liniment

[0064] etodolac 45g

[0065] Ethanol 35ml

[0066] Propylene glycol 180ml

[0067] Add phosphate buffered saline (PBS) to 1000ml

[0068] Preparation Process:

[0069] First dissolve etodolac in the prescribed amount of ethanol and propylene glycol, and then add the prescribed amount of phosphate buffer saline (PBS).

Embodiment 2

[0071] etodolac common liniment

[0072] etodolac 45g

[0073] Ethanol 200ml

[0074] Propylene glycol 500ml

[0075] Add distilled water to 1000ml

[0076] Preparation Process:

[0077] First dissolve etodolac in the prescribed amount of ethanol and propylene glycol, and then add distilled water to 1000ml. The preparation described in this method can also be made into a liniment in a specific container.

Embodiment 3

[0079] etodolac ointment

[0080] etodolac 45g

[0081] Capomer 940 20

[0082] Hypromellose 40g

[0083] Glycerin 400g

[0084] Ethylparaben 2g

[0085] Add distilled water to 1000ml

[0086] Preparation Process:

[0087] Disperse hydroxypropyl methylcellulose in hot water at about 80°C, cool it to form a clear solution, and disperse Carbomer 940 in water and mix it with glycerin, mix the above solution, and then add the dissolved prescription amount Put the hot distilled water of etodolac until it swells into a gel, then add an aqueous solution containing ethylparaben, and add water to a sufficient amount to obtain etodolac ointment.

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Abstract

Osteoarthritis and rheumatoid arthritis are common chronic diseases, which have high morbidity and hard to heal, therefore a long period medicine treatment is required. Life of the patient can be threatened if the long period medicine treatment is not well insisted. Currently, among medicine for arthritis, nonsteroidal anti-inflammatory drugs are most important. But currently oral preparation account for the most portions, which has more side effects. Etodolac belongs to the indole nonsteroidal anti-inflammatory drugs, which play an important role in arthritis treatment. But the current oral preparation has a plurality of side effects, which brings trouble to the long period treatment in patients. Therefore the present invention develops an external preparation of Etodolac, which not only greatly reduces side effects of the drugs, but also applicable for long period treatment of arthritis particularly.

Description

Technical field [0001] The invention belongs to new pharmaceutical preparations. Background technique [0002] Arthritis is a common chronic disease, the most common of which are osteoarthritis and rheumatoid arthritis. It is estimated that there are more than 100 million arthritis patients in my country, and the number is still increasing. According to statistics, half of the people over the age of 50 in my country suffer from osteoarthritis; 90% of the women and 80% of the men over the age of 65 suffer from osteoarthritis. The prevalence of rheumatoid arthritis in my country is 0.34% to 0.36%. According to reports, the life expectancy of patients with severe rheumatoid arthritis is shortened by about 10 to 15 years. Arthritis is not a disease of old age and can affect people of all ages, including children. [0003] (1) Osteoarthritis (OA) is a chronic joint disease characterized by degeneration and destruction of articular cartilage and bone hyperplasia. Osteoarthritis...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K9/06A61K9/107A61K9/12A61K31/407A61P19/02A61P29/00
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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