External applied preparation for etodolac

Abstract

Osteoarthritis and rheumatoid arthritis are common chronic diseases, which have high morbidity and hard to heal, therefore a long period medicine treatment is required. Life of the patient can be threatened if the long period medicine treatment is not well insisted. Currently, among medicine for arthritis, nonsteroidal anti-inflammatory drugs are most important. But currently oral preparation account for the most portions, which has more side effects. Etodolac belongs to the indole nonsteroidal anti-inflammatory drugs, which play an important role in arthritis treatment. But the current oral preparation has a plurality of side effects, which brings trouble to the long period treatment in patients. Therefore the present invention develops an external preparation of Etodolac, which not only greatly reduces side effects of the drugs, but also applicable for long period treatment of arthritis particularly.

Description

Technical field

[0001] The invention belongs to new pharmaceutical preparations. Background technique

[0002] Arthritis is a common chronic disease, the most common of which are osteoarthritis and rheumatoid arthritis. It is estimated that there are more than 100 million arthritis patients in my country, and the number is still increasing. According to statistics, half of the people over the age of 50 in my country suffer from osteoarthritis; 90% of the women and 80% of the men over the age of 65 suffer from osteoarthritis. The prevalence of rheumatoid arthritis in my country is 0.34% to 0.36%. According to reports, the life expectancy of patients with severe rheumatoid arthritis is shortened by about 10 to 15 years. Arthritis is not a disease of old age and can affect people of all ages, including children.

[0003] (1) Osteoarthritis (OA) is a chronic joint disease characterized by degeneration and destruction of articular cartilage and bone hyperplasia. Osteoarthritis...