Traditional Chinese medicine composition having anticancer effect and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the direction of drug combination, medical preparations containing active ingredients, antineoplastic drugs, etc., to achieve the effect of simple preparation method, obvious effect and good therapeutic effect

Inactive Publication Date: 2011-10-26
TIANJIN UNIV
View PDF7 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no anticancer effect has been found, and the traditional Chinese medicine composition composed of papaya saponin extract and turmeric water extract has been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Traditional Chinese medicine composition having anticancer effect and preparation method thereof
  • Traditional Chinese medicine composition having anticancer effect and preparation method thereof
  • Traditional Chinese medicine composition having anticancer effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1) Extraction of saponins

[0018] (1) With 500g of the coarse powder of Chonglou after passing through a 4-mesh sieve, soak the sieved coarse powder in 2 liters of ethanol solution with a mass concentration of 60% for 1 hour, then heat and reflux for extraction at a temperature of 90° C. for 2 hours, and recover and extract 1.8 liters of liquid, and reflux extraction was carried out twice according to the operating conditions of the first reflux extraction. After combining 5.4 liters of the three extractions, evaporate at a concentration temperature of 80°C to obtain a concentrated solution with a volume of 0.5 L.

[0019] (2) Add 0.5L of the concentrated solution from step (1) into 5L of a 1% ethanol solution to disperse evenly, and centrifuge to obtain 4.8L of supernatant.

[0020] (3) 4.8L supernatant is 0.8L by column volume with the flow rate of 2.4L per hour, and diameter-to-height ratio is the D101 large adsorption resin chromatography column of 1: 5, discards e...

Embodiment 2

[0025] 1) Extraction of saponins

[0026] (1) With 500g of the coarse powder of Chonglou after passing through a 4 mesh sieve, soak the sieved coarse powder in 2.5 liters of ethanol solution with a mass concentration of 70% for 1 hour, then heat and reflux for extraction at a temperature of 90° C. for 2 hours, and recover and extract 2.3 liters of liquid, and reflux extraction was carried out twice according to the operating conditions of the first reflux extraction. After combining 6.9 liters of the three extractions, evaporate at a concentration temperature of 80°C to obtain a concentrated solution with a volume of 0.5 L.

[0027] (2) Add 0.5 L of concentrated solution obtained in step (1) into 4 L of 10% ethanol solution to disperse evenly, and centrifuge to obtain 3.9 L of supernatant.

[0028] (3) The 3.9L supernatant is passed through a column volume of 800mL at a flow rate of 1.6L per hour, and the diameter-to-height ratio is a D101 large adsorption resin chromatography...

Embodiment 3

[0034] 1) Extraction of saponins

[0035](1) With 500 g of the coarse powder of Chonglou after passing through a 4-mesh sieve, soak the sieved coarse powder in 3 liters of ethanol solution with a mass concentration of 70% for 1 hour, then heat and reflux for extraction at a temperature of 90° C. for 2 hours, and recover and extract 2.8 liters of liquid, and reflux extraction was carried out twice according to the operating conditions of the first reflux extraction. After combining 8.4 liters of the three extractions, evaporate at a concentration temperature of 80°C to obtain a concentrated solution with a volume of 0.5 L.

[0036] (2) Add 0.5 L of the concentrated solution obtained in step (1) into 3.5 L of 20% ethanol solution to disperse evenly, and centrifuge to obtain 3.9 L of supernatant.

[0037] (3) The 3.9L supernatant is passed through a column volume of 800mL at a flow rate of 1.6L per hour, and the diameter-to-height ratio is a D101 large adsorption resin chromatogr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a traditional Chinese medicine composition having an anticancer effect and a preparation method thereof. The traditional Chinese medicine composition is a medicament mixture composed of a polyphyllin extract and a turmeric water extract in a mass ratio of 2:3. The preparation process of the traditional Chinese medicine composition comprises the following steps: preparing the polyphyllin extract; preparing the turmeric water extract; and preparing a mixture of the polyphyllin extract and the turmeric water extract. The traditional Chinese medicine composition has the advantages that: the preparation process is simple; the obtained traditional Chinese medicine composition has the anticancer effect, and the anticancer activity of the composition is high and has broad spectrum; and compared with singly applied polyphyllin extract or turmeric water extract, the composition has stronger antitumour activity, smaller toxic and side effects and immunity-enhancing function.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition with anticancer effect and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] The traditional Chinese medicine Zhonglou is the rhizome of Paris polyphylla Smith var. yannanensis (Paris polyphylla Smith var. yannanensis) and Paris polyphylla Smith var. It has the effects of relieving swelling and pain, cooling the liver and relieving convulsions. It is used to treat bloated, sore throat, poisonous snake bites, bruises, cold wind convulsions, etc. It is a famous Chinese patent medicine Yunnan Baiyao, Jidesheng snake tablet, Gongxuening capsule, etc main components of the drug. Modern pharmacological effects show that the drug has the effects of hemostasis, expectoration, bacteriostasis, analgesia and sedation, anti-early pregnancy, spermicide, and anti-cytotoxicity. It is clinically used in the treatment of func...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K36/896A61P35/00
Inventor 高文远尹双双满淑丽刘振
Owner TIANJIN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap