Traditional Chinese medicine composition and application as radiotherapy sensitizer

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve the problems of unsatisfactory radiosensitizing drugs, high toxicity of sensitizer drugs, poor drug targeting, etc., and achieve good anticancer activity, easy availability of raw materials, and preparation simple effect

Active Publication Date: 2012-03-28
张剑
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The research on radiosensitizers has a history of 40 to 50 years, but there is still no satisfactory radiosensitizer for clinical use
The current clinical use of radiosensitizer drugs has problems such as high toxicity of sensitizer drugs, poor drug targeting or poor sensitization effect

Method used

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  • Traditional Chinese medicine composition and application as radiotherapy sensitizer
  • Traditional Chinese medicine composition and application as radiotherapy sensitizer
  • Traditional Chinese medicine composition and application as radiotherapy sensitizer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 Chinese medicine composition mixture of the present invention

[0021] Prescription: 10 parts of toad skin, 6 parts of mylabris, 10 parts of Panax notoginseng, 10 parts of leech, 20 parts of curcuma, 20 parts of wood beetle, 10 parts of pangolin, 15 parts of astragalus, 30 parts of coix seed, 5 parts of angelica, 10 parts of licorice.

[0022] Preparation method: Take the medicinal materials of the above weight components, add water 5 times the total weight of the medicinal materials, soak for 30 minutes, decoct twice for 2 hours each time, filter, combine the filtrates, and concentrate the filtrates under reduced pressure to a relative density of 1.1 The extract, the relative density is the test result at 60 degrees Celsius, add ethanol until the alcohol content is 75% (v / v), let it stand for 24 hours, take the supernatant, recover the ethanol to concentrate, add water to 1000ml, stir Mix evenly, sub-package, and sterilize with circulating steam for 35 min...

Embodiment 2

[0023] Embodiment 2 Chinese medicine composition tablet of the present invention

[0024] Prescription: 5 parts of toad skin, 6 parts of mylabris, 5 parts of Panax notoginseng, 10 parts of leech, 20 parts of curcuma, 20 parts of ground beetle, 5 parts of pangolin, 10 parts of astragalus, 20 parts of coix seed, 5 parts of angelica, and 5 parts of licorice.

[0025] Preparation method: Take each medicinal material of the above weight components, add water 10 times the total weight of the medicinal materials, soak for 60 minutes, decoct once, 1 hour each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of 1.25 The extract, the relative density is the test result at 60 degrees Celsius, add ethanol until the alcohol content is 80% (v / v), let it stand for 24 hours, take the supernatant, recover the ethanol until concentrated, vacuum dry, and prepare Granules, ready to be compressed into tablets.

Embodiment 3

[0026] Embodiment 3 Chinese medicine composition capsule of the present invention

[0027] Prescription: 10 parts of toad skin, 8 parts of mylabris, 10 parts of Panax notoginseng, 15 parts of leech, 30 parts of curcuma, 30 parts of wood beetle, 10 parts of pangolin, 15 parts of astragalus, 30 parts of coix seed, 15 parts of angelica, 15 parts of licorice.

[0028] Preparation method: Take the medicinal materials of the above weight components, add water 8 times the total weight of the medicinal materials, soak for 45 minutes, decoct 4 times for 1.5 hours each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of 1.2 The extract, the relative density is the test result at 60 degrees Celsius, add ethanol until the alcohol content is 90% (v / v), let it stand for 24 hours, take the supernatant, recover the ethanol to concentrate, vacuum dry, and prepare Capsules, ready to pack into capsules.

[0029] The second part, the p...

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Abstract

The invention discloses a traditional Chinese medicine composition and its application as a radiotherapy sensitizer, and belongs to the field of traditional Chinese medicine. Since no quite effective pharmacotherapy is provided for solid tumors currently, a first purpose of the invention is to provide a traditional Chinese medicine composition for treating solid tumors, which comprises the following components: 5-10 parts of toad skin, 6-8 parts of mylabris, 5-10 parts of panax notoginseng, 10-15 parts of leeches, 20-30 parts of curcuma rhizome, 20-30 parts of ground beetles, 5-10 parts of pangolins, 10-15 parts of radix astragali, 20-30 parts of coix seeds, 5-15 parts of angelica, and 5-15 parts of licorice. The traditional Chinese medicine composition has very good anticancer activity with respect to solid tumors such as lung cancer and the like, and can be used as a radiotherapy sensitizer.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine composition and its application as a radiotherapy sensitizer. Background technique [0002] In the field of medicine, cancer is one of the major diseases that seriously affect human health and threaten human life. Together with cardiovascular and cerebrovascular diseases and accidents, cancer constitutes the top three causes of death in all countries in the world today. Therefore, the World Health Organization and the health departments of governments of various countries have listed conquering cancer as a top priority. There are three main ways to treat cancer in the world: surgery, chemotherapy and radiotherapy. About 45% of cancer patients can be cured, of which 18% are cured by radiotherapy. In the treatment of cancer patients, about 70% have received radiation therapy. [0003] Radiation therapy is to irradiate cancer tissue with radiation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/00A61K35/36A61K35/56A61K35/62A61K35/64A61K35/65
Inventor 黄丙俭
Owner 张剑
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