121results about How to "Easy to inactivate" patented technology

A gas-introducing system for plasma CVD and cleaning includes: a showerhead including a top plate with a gas inlet port and a shower plate; a rectifying plate installed in the interior space of the showerhead and dividing the interior space into an upper space and a lower space; a structure for inhibiting inactivation of active species of the activated cleaning gas at the rectifying plate; and a piping unit for connecting the gas inlet port of the showerhead to a remote plasma unit and a reaction gas introduction port.

Disclosed are compositions for collecting, storing, and transporting populations of nucleic acids from biological specimens, and clinical, forensic, or environmental samples. Also disclosed are methods for using these compositions as one-step formulations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing or assay. In particular embodiments, the invention provides a single, one-step, sample collection / transport / storage formulation containing a known quantity of a non-genomic, nucleic acid carrier molecule that serves as an internal reference control to monitor the fidelity of the collection / transportation medium, and measure the integrity of nucleic acids subsequently isolated and purified from the processed sample.

PCT No. PCT / JP98 / 01904 Sec. 371 Date Aug. 13, 1999 Sec. 102(e) Date Aug. 13, 1999 PCT Filed Apr. 24, 1998 PCT Pub. No. WO98 / 48043 PCT Pub. Date Oct. 29, 1998A sample containing a glycated protein is treated with Protease XIV or a protease from Aspergillus genus, thereafter (or while treating the sample with the above protease) FAOD (fructosyl amino acid oxidase) is caused to react with the sample so as to measure the amount of oxygen consumed by the FAOD reaction or the amount of the resultant reaction product, thereby to measure the glycated protein. According to the above method, the glycated protein can be fragmented while the decomposition of the FAOD itself is prevented, thereby to facilitate the binding of the protein with the FAOD and to improve the sensitivity of the detection.

Disclosed are compositions for collecting, storing, and transporting populations of nucleic acids from biological specimens, and clinical, forensic, or environmental samples. Also disclosed are methods for using these compositions as one-step formulations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing or assay. In particular embodiments, the invention provides a single, one-step, sample collection / transport / storage formulation containing a known quantity of a non-genomic, nucleic acid carrier molecule that serves as an internal reference control to monitor the fidelity of the collection / transportation medium, and measure the integrity of nucleic acids subsequently isolated and purified from the processed sample.

A highly sensitive method is provided for the detection of prions in a sample. These methods may be used to diagnose prion mediated transmissible spongiform encephalopathies such as bovine spongiform encephalopathy, Creutzfeldt-Jakob disease, scrapie, or chronic wasting disease. In particular a method for serial automated cyclic amplification of prion is disclosed. The method is both rapid and highly sensitive making it ideal for high throughput testing.

The present invention discloses a preparation process of heavy oil hydrogenating, demetallizing and desulfruizing catalyst. Aluminum containing material in two different forms, including roasted alumina and dry aluminum hydroxide glue powder, is used. Of the assistant alkali metal element and / or alkali earth metal element, part is mixed with dry aluminum hydroxide glue powder and part is loaded onto the carrier via soaking process, so as to result in the inhomogeneous distribution of the assistant on the carrier. The catalyst has high demetalizing activity and desulfurizing activity, and highactivity stability, especially high desulfurizing activity stability. The catalyst may be used in the hydrodemetalizing and hydrodesulfurizing treatment of heavy oil and residual oil.

The invention discloses a preparation method of heavy oil hydrogenation demetallization and desulfurization catalyst, which uses two kinds of aluminum-containing materials in different forms, one is calcined alumina, the other is aluminum hydroxide dry rubber powder, and the alkali metal And / or alkaline earth metal elements are additives, the additives are pre-mixed with aluminum hydroxide dry rubber powder, and part is loaded on the catalyst by impregnation method, so that the additives are unevenly distributed on the catalyst. The catalyst prepared by the method of the invention has high demetallization activity and desulfurization activity at the same time, and the stability of activity, especially the stability of desulfurization activity is good. It can be used in hydrodemetallization and hydrodesulfurization of heavy and residual oil.

The present invention relates to methods arid compositions for isolating hemoglobin from red blood cells. Such methods and compositions also facilitate viral inactivation in a manner that allows recovery of biologically active hemoglobin. More particularly, this method relates to the use of solvents and detergents that are capable of facilitating red blood cell lysis to release hemoglobin (and solubilizing red blood cell membranes), while simultaneously inactivating viruses.

The invention disclosed in this application relates to a pharmaceutical formulation prepared from the biotyped variety of the medicinal plant, Phyllanthus amarus which is useful for the treatment of Hepatitis B (both acute and chronic), Hepatitis C (both acute and chronic) and other related viral infections of the liver with antihepatotoxic and liver cell regenerating potentials and immunomodulating properties. The invention confirms, that when pars of the biotyped variety of the medicinal plant, Phyllanthus amarus are extraceted separately with a polar solvent alone, polar solvent and water in specific ratios and water alone and when such extracts are mixed together, the resultant formulation has all the essential antiviral and biological properties, while the individual polar or aqueous extracts alone does not possess one or more of these properties. The present invention also relates to a process for the preparation of the above said new pharmaceutical formulation with biological and chemical standardisation protocols.

Washing and cleaning agents containing benzophenone or benzole anilide derivatives containing carboxyl groups, which function as protease inhibitors and are suitable as enzyme stabilizers. Additional subjects are the use of such compounds as reversible inhibitors of a protease and consequently for a washing or cleaning agent formulation, and additional methods and uses relating thereto.

Disclosed is an anti-viral member which can inactivate a virus. Specifically disclosed is an anti-viral member which is characterized by comprising a base material, univalent copper compound microparticles, and inorganic microparticles which are provided for the purpose of retaining the univalent copper compound microparticles on the base material and each of which has a silane monomer bound to the surface thereof via a chemical bond, wherein the inorganic microparticles are bound to one another via chemical bonds formed between the silane monomers provided on the surfaces thereof, and each of the inorganic microparticles is bound to the base material via a chemical bond between the silane monomer and the base material to form spaces in which the univalent copper compound microparticles are to be retained. The anti-viral member has an extremely high anti-viral activity compared to those achieved by the conventional binder immobilization techniques, and is applicable to various materials or various products to which the materials are applied.

An air treatment system includes a housing defining a chamber, and an ultraviolet lamp positioned within the chamber. The housing further defines an air inlet at a first end portion of the housing and an air outlet at a second end portion of the housing opposing the first end portion. The chamber provides flow communication between the air inlet and the air outlet. At least one ultraviolet lamp is positioned within the chamber. The at least one ultraviolet lamp is positioned about a first axis and includes a first end and a second end spaced with respect to the first end along the first axis. The at least one ultraviolet lamp is configured for facilitating inactivating contaminants within air channeled through the chamber.

The invention provides an article of manufacture comprising a substantially non-immunogenic xenograft for implantation into humans. The xenograft is a body part dissected from a transgenic 1,3-α-galactosyltransferase gene-deficient animal, wherein the cells of the body part are dead. The invention also provides methods for preparing a xenograft by removing a body part from a transgenic animal, which is 1,3-α-galactosyltransferase gene-deficient, to provide a xenograft; optionally washing the xenograft in saline and alcohol; subjecting the xenograft to a cellular disruption treatment; optionally treating the xenograft with crosslinking agents, and optionally treating the xenograft with a proteoglycan-depleting factor. The invention further provides a method for sterilizing xenograft material, having the steps of obtaining substantially non-immunogenic xenograft material; treating the xenograft material with at least one crosslinking agent; and subjecting the crosslinked xenograft material to a radiation treatment.

The present invention relates to an indoor air cleaning unit which mainly comprises a dust removing unit, an active carbon absorbing unit and an ultraviolet sterilizing unit. The dust removing unit adopts an electrostatic dust collecting structure and is provided with dust collecting plates parallel with each other and discharge electrodes distributed between the dust collecting boards. The active carbon absorbing unit is obtained by stacking a plurality of activated carbon fiber blocks. The ultraviolet sterilizing unit is provided with a plurality of photocatalytic modules which are arranged transversely and are composed of a plurality of layers of photocatalytic wire meshes. An ultraviolet lamp and an ultrasonic atomizer are installed between each photocatalytic module. The ultrasonic atomizer is provided with a water supplying device. The device has a simple structure, fully exerts the synthetic predominance of a plurality of purifying techniques and effectively settles the problem of indoor air pollution.

The invention discloses a liposome calcium phosphate nanoparticle (Lipide calcium phosphate nanoparticles LCP NP), which is specifically prepared by using liposome-wrapped calcium phosphate nanoparticles as a carrier and a delivery medium, and wrapping cell growth factor (FGF) therein It can be used as cosmetic raw material or active additive, and can be further prepared into foam, water, emulsion, gel or cream. The composition has the functions of moisturizing, moisturizing, repairing, and anti-aging. The liposomal calcium phosphate nanoparticles can also make the active ingredients carried deep into the deep skin, activate deep skin cells, and play a role in rebuilding the skin barrier, repairing sensitive skin, and anti-wrinkle. The role of skin rejuvenation.

Described herein are improved purification methods for virus vaccines and compositions. Also described are Zika, Chikungunya, dengue and yellow fever vaccines and methods of producing and administering said vaccines to subjects in need thereof.

The invention provides a catalyst for conversion of ethyl levulinate into gamma-valerolactone and a preparation method of the catalyst. The catalyst comprises two parts, namely, sulfonic acid functionalized hafnium-based-metal organic framework material SO3H-MOF (Hf) and noble metal Ru nano-particles, wherein the noble metal Ru accounts for 0.5%-5% of the total weight of the catalyst, and the sulfonic acid group SO3H accounts for 0-20% of the total weight of the catalyst. The preparation method comprises the steps as follows: adding hafnium tetrachloride, terephthalic acid and monosodium 2-sulfoterephthalate to a mixed solution of dimethylformamide and acetic acid, and performing crystallizing, washing and drying to obtain the sulfonic acid functionalized hafnium-based-metal organic framework material SO3H-MOF (Hf); then, adding a RuCl3 solution dropwise to obtain a catalyst precursor, performing reduction on the catalyst precursor with sodium borohydride, and performing aftertreatment on the catalyst precursor with hydrochloric acid to obtain the catalyst. The catalyst has better catalytic activity, selectivity and reusability when used for conversion of ethyl levulinate into gamma-valerolactone.

The invention discloses a method for preparing an anti-microbial, mildew-resistant and corrosion-resistant membrane layer on a magnesium metal surface. Firstly a magnesium metal is pretreated, and then is put in an oxidation fluid. An alternating current with a current density of 0.5-2.5 A / dm<2> is connected. A layer of oxidation functional membrane is formed after the treatment is carried out for 10-40 minutes at the temperature of 15-30 DEG C. Then the magnesium metal is rinsed by deionized water and is sealed t in the pure water. The oxidation membrane layer with the thickness of 3-15[mu]m is obtained on the magnesium metal surface. The oxidation fluid contains the following solute: 40-80g / L NaOH, 50-90g / L Na2SiO3, 40-80g / L Na2B4O7, and 8-16g / L citric acid, and also contains soluble anti-microbial and mildew-resistant functional element salts. The magnesium metal surface after treatment by the method of the invention has a layer of the oxide membrane which takes a magnesia ceramic phase as a matrix. The anti-microbial and mildew-resistant functional elements Ag and Ni are dispersed and distributed in a matrix phase. The membrane layer has the good anti-microbial and mildew-resistant performance and good corrosion resistance, and can be used in many fields such as package and storage of food and clothing, and human body implantation medical instruments.

The invention relates to a raoultella ornithinolytica GJ-5 strain and an application thereof. The strain has a collection number of CGMCC NO. 9837; and a 16SrDNA sequence is shown in SEQ ID NO. 1. The raoultella ornithinolytica is streaked on a solid isolation culture medium and is cultured for 24 hours at 30 DEG C; a single colony is inoculated into a 100mL LB culture medium and is cultured for 24 hours in a 150r.min<-1> constant-temperature shaker at 30 DEG C; the single colony is then inoculated into liquid culture media under different conditions and is cultured for 24 hours in a 150r.min<-1> constant-temperature shaker at 30 DEG C, and then the removal efficiency of ammonia nitrogen and the OD600 value are measured. According to the strain, when the ratio of C to N is 6, the removal efficiency of ammonia nitrogen is 52.8% and the strain has good nitrosation and denitrification effects under aerobic condition and is easily inactivated.

A two-way CATV system is easy of maintenance, stable of a transmission quality and capable of restraining inter-modulation distortion noises of downstream RF signal carriers which are caused by non-linearity of electric contact members of coaxial connectors among upstream ingress noises becoming a problem when performing communications services by utilizing a CATV transmission path. The two-way CATV system comprises at least one bidirectional amplifier provided on a CATV transmission path for connecting a CATV center station to a subscriber home, a bias voltage superposing element for superposing, with a bias voltage, a downstream signal transmitted along a coaxial transmission path subordinate to an amplifier at the terminal among the bidirectional amplifiers, and a bias current adjusting load element, provided at the end of the coaxial transmission path, for setting the bias current corresponding to an application of the bias voltage superposed by the bias voltage superposing element.

The invention relates to a preparation method of a compound microbial flocculant for cyanobacterial bloom. The preparation method comprises the following steps: respectively inoculating Serratia and Bacillus into a sterilized nutrient broth medium for culture; respectively taking out 1mL of bacterial liquids of Serratia and Bacillus after culturing for 24h, and inoculating into a sterilized fermentation medium for fermentation culture; treating a broth as a seed liquid after culturing for 72 h and carrying out complex culture for 72h under conditions of a culture temperature of 35 DEG C, a rotation speed of 160rpm, an initial pH of a medium of 8.0, and an inoculation amount of the seed liquid of 10 ml / L; and carrying out centrifugal separation on the broth, and taking out a supernatant liquor. So the compound microbial flocculant is obtained. The preparation method is simple, fast and low cost, the flocculant prepared in the invention has the advantages of small dosage in use, strong stability and easy storage, can effectively flocculate cyanobactreial water samples with a flocculation rate of 92%, and has an excellent application prospect.

The invention relates to an ethinyl estradiol high-efficiency degrading strain and a preparation method thereof. The thallus length of the strain is 0.4-0.8um; and the bacterial colony has a diameter of 1-2.5mm, is round in shape, has regular edges and a low convex surface, is golden yellow in color with no luster and no transparency, and appears as negative through Gram staining. The preparation method comprises the following steps: carrying out directional domestication and culture on active sludge, enriching, separating, and purifying to obtain the ethinyl estradiol high-efficiency degrading strain. The ethinyl estradiol high-efficiency degrading strain can effectively degrade ethinyl estradiol, has an ethinyl estradiol degradation rate up to 80% or above, has no resistance to common antibiotics, and can be inactivated easily, thereby ensuring the ecological safety in use. Besides, the ethinyl estradiol high-efficiency degrading strain has the advantages of easy acquisition of sources and convenient separation and purification method.

The present invention provides an sgRNA specifically targeting a human DNMT1 gene based on a CRISPR / Cas9 system, a use thereof for guiding the CRISPR / Cas9 system in a drug for treatment and / or prevention of tumors, and a method correspondingly constructing a sgRNA expression vector. The CRISPR / Cas9 system can rapidly, efficiently and specifically knock out the human DNMT1 gene, induces inactivation of the DNMT1 gene in tumor cells, inhibits expression of the DNMT1 and methylation of DNA and thus inhibits tumor cell growth.

The invention discloses banana and brown rice blended powder capable of relaxing bowels. The banana and brown rice blended powder is prepared from the following raw materials in parts by weight: 60 to 90 parts of brown rice, 20 to 30 parts of buckwheat, 10 to 15 parts of purple sweet potato whole wheat flour, 8 to 12 parts of jack bean meal, 15 to 20 parts of oat bran, 10 to 15 parts of bananas, 10 to 15 parts of figs, 6 to 9 parts of dragon fruit flowers, 4 to 6 parts of whey protein powder, 4 to 6 parts of corn gluten meal, 1 to 2 parts of Momordica grosvenori, an appropriate amount of high temperature resistant alpha-amylase and an appropriate amount of a stabilizer. By adopting germination, extrusion and coprocessing of the high temperature resistant alpha-amylase, the blending property of puffing powder can be obviously improved, the digestion utilization rate of the powder is greatly improved, water-soluble dietary fiber is extracted through ultrasonic enzymolysis after oat bran degreasing, the raw materials are low in cost, the content of the dietary fiber in a finished product reaches the specification of national high dietary fiber food, the raw materials such as bananas and figs are added to improve the single mouth feel of grains, the palatability of the finished product is improved, and the banana and brown rice blended powder has the health efficacy of relaxing bowels after long-term eating.

The present invention relates to a levofloxacin hydrochloride micropill capsule and its preparation method. It is composed of capsule external shell and micropill, the micropill is formed from levofloxacin hydrochloride, blank pill core and adhesive, every pill contains (by wt%) 10%-80% of levofloxacin hydrochloride, 15%-60% of medicine micropill pill core and 5%-30% of adhesive. Besides, said invention also provides the concrete steps of its preparation method.