The present invention provides a composition comprising i) a pseudotyped retroviral vector particle or
virus-like particle thereof comprising a) one envelope
protein with
antigen-binding activity, wherein said envelope
protein is a recombinant
protein that does not interact with at least one of its native
receptor(s) and is fused at its
ectodomain to a polypeptide comprising an
antigen binding domain specific for a tag of a tagged polypeptide, and wherein said envelope protein is
protein G, HN or H derived from the
Paramyxoviridae family, and b) one envelope protein with fusion activity derived from the
Paramyxoviridae family, and ii) said tagged polypeptide, wherein said tagged polypeptide binds specifically to an
antigen expressed on the surface of a target
cell, thereby transducing thetarget
cell with said retroviral vector particle or thereby inducing uptake of the
virus-like particle into the target
cell. A pharmaceutical composition thereof and an
in vitro method for transduction of targets cells with said vector particle are also disclosed.