Preparation method of composite magnetic nano photosensitizer
A composite magnetic and magnetic nanotechnology, applied in the field of genetic engineering, can solve problems such as non-tissue specificity
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[0028] The present invention will be further specifically described below by way of examples.
[0029] Main steps of the present invention include:
[0030] (1) Fe 3 o 4 @SiO 2 Preparation of @Qdots / PS Composite Nanoparticles: Co-precipitation Method to Prepare Iron Tetroxide Magnetic Nanoparticles Fe 3 o 4 , coated with a thin layer of silicon dioxide on its surface to form Fe 3 o 4 @SiO 2 ; Select quantum dots (Qdots) with an emission wavelength of 630nm and a photosensitizer dihematoporphyrin ether (PS) with an absorption wavelength of 630nm, and assemble them on Fe through adsorption 3 o 4 @SiO 2 On the surface, the photosensitizer dihematoporphyrin ether was dissolved in saline to make 0.1mg / ml, mixed with CdTe colloidal solution (0.1mg / ml), and slowly dropped into Fe 3 o 4 @SiO 2 (0.1mg / ml) solution, pass N 2 Stir the reaction at room temperature overnight, 1×10 6 rpm ultracentrifugation to precipitate Fe 3 o 4 @SiO 2 @Qdots / PS nanoparticles, resuspended...
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