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Preparation method of composite magnetic nano photosensitizer

A composite magnetic and magnetic nanotechnology, applied in the field of genetic engineering, can solve problems such as non-tissue specificity

Inactive Publication Date: 2019-03-12
SOUTHEAST UNIV
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Problems solved by technology

However, in these studies, bioluminescence as the energy source of PDT is not tissue-specific, and its main constraint is that, in order to meet the conditions of energy resonance transfer, the luciferase that produces bioluminescence usually needs to be compatible with the energy acceptor. Covalently bonded together, but not specifically expressed in tumor cells

Method used

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  • Preparation method of composite magnetic nano photosensitizer
  • Preparation method of composite magnetic nano photosensitizer
  • Preparation method of composite magnetic nano photosensitizer

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Embodiment Construction

[0028] The present invention will be further specifically described below by way of examples.

[0029] Main steps of the present invention include:

[0030] (1) Fe 3 o 4 @SiO 2 Preparation of @Qdots / PS Composite Nanoparticles: Co-precipitation Method to Prepare Iron Tetroxide Magnetic Nanoparticles Fe 3 o 4 , coated with a thin layer of silicon dioxide on its surface to form Fe 3 o 4 @SiO 2 ; Select quantum dots (Qdots) with an emission wavelength of 630nm and a photosensitizer dihematoporphyrin ether (PS) with an absorption wavelength of 630nm, and assemble them on Fe through adsorption 3 o 4 @SiO 2 On the surface, the photosensitizer dihematoporphyrin ether was dissolved in saline to make 0.1mg / ml, mixed with CdTe colloidal solution (0.1mg / ml), and slowly dropped into Fe 3 o 4 @SiO 2 (0.1mg / ml) solution, pass N 2 Stir the reaction at room temperature overnight, 1×10 6 rpm ultracentrifugation to precipitate Fe 3 o 4 @SiO 2 @Qdots / PS nanoparticles, resuspended...

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Abstract

The invention relates to a preparation method of a composite magnetic nano photosensitizer. The preparation method includes preparing Fe3O4 magnetic nanoparticles, using tetraethoxysilane as a modifier to coat the surface of the Fe3O4 magnetic nanoparticles with a thin layer of silica, and fitting quantum dots CdT and a photosensitizer on the surface under the adsorbing action of silica mesoporousmicrospheres to obtain magnetic nano photosensitizer particles Fe3O4@SiO2@Qdots / PS. Specific bioluminescence of tumor cells can be used as a light source; the photosensitizer is excited to generate active oxygen clusters and convert electricity energy of an alternating electric field into thermal energy; the composite magnetic nano photosensitizer is a novel multifunctional photosensitizer.

Description

technical field [0001] The invention belongs to the field of genetic engineering, and in particular relates to a preparation method and application of a composite magnetic nano photosensitizer. Background technique [0002] Photodynamic therapy (PDT) uses a light source of a certain wavelength to irradiate the photosensitizer, and the excited photosensitizer interacts with oxygen molecules to generate reactive oxygen species (ROS) mainly composed of singlet oxygen (single oxygen), thereby Toxic to cells. Photodynamics is an effective, non-invasive means of tumor killing. However, in the more than 30 years of its clinical application, photodynamics has not been able to become the main means of tumor killing (except for superficial skin cancer), only as a palliative killing or an auxiliary of other killing methods, the main reason is that it kills tumor tissue limitations and gradually revealed adverse reactions. Whether the laser is directly irradiated or the optical fiber...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/14A61K47/04A61P35/00B82Y5/00
CPCA61K9/143A61K41/0052A61K41/0076A61P35/00B82Y5/00
Inventor 袁晨燕安艳丽张东生
Owner SOUTHEAST UNIV
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