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A microcapsule for recovering the susceptibility of drug-resistant bacteria and its preparation method

A technology for sensitive and drug-resistant bacteria, applied in the direction of bacteria, etc., to achieve strong effects, improve bioavailability, and improve absorption

Active Publication Date: 2018-03-30
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in order to maximize the synergistic effect of restoring sensitivity when β-galactosylated azocenediol and ampicillin are used to treat drug-resistant bacteria, how should the NO donor be linked to ampicillin to achieve targeting? How to choose the best solvent for dissolving NO donor drug and ampicillin? What is the ratio? What kind of preparation technology can be used to make the combination drug more stable, have a longer duration of action, and have a better effect? None of these issues have been resolved

Method used

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  • A microcapsule for recovering the susceptibility of drug-resistant bacteria and its preparation method

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Effect test

Embodiment 1

[0014] A microcapsule for recovering the susceptibility of drug-resistant bacteria consists of β-galactosylated azocenediol, ampicillin, lysine reaction product, isopropylthiogalactoside, capsule material, emulsifier, Sweeteners, preservatives, antioxidants and additives are formulated and emulsified; the mass ratio of β-galactosylated azocenediol, ampicillin, isopropylthiogalactoside and lysine is 1:6:4:8; based on the total mass percentage of microcapsules, capsule material is 1.5%, emulsifier is 0.1%, sweetener is 0.03%, preservative is 0.01%, antioxidant is 0.1%, additive 0.25%. The capsule material is sodium alginate; the sweetener is sodium saccharin; the emulsifier is Tween 80; the preservative is eucalyptus oil 80; the antioxidant is sodium metabisulfite; Lidocaine is a topical analgesic. The preparation method of the microcapsules for recovering the sensitivity of drug-resistant bacteria, the preparation method is specifically: 1) at room temperature, the β-galactos...

Embodiment 2

[0016] A microcapsule for recovering the susceptibility of drug-resistant bacteria consists of β-galactosylated azocenediol, ampicillin, lysine reaction product, isopropylthiogalactoside, capsule material, emulsifier, Sweeteners, preservatives, antioxidants and additives are formulated and emulsified; the mass ratio of β-galactosylated azocenediol, ampicillin, isopropylthiogalactoside and lysine is 2:1:4:2; based on the total mass percentage of microcapsules, capsule material is 2.0%, emulsifier is 0.3%, sweetener is 0.03%, preservative is 0.05%, antioxidant is 0.2%, additive 0.25%. The capsule material is sodium alginate; the sweetener is sodium saccharin; the emulsifier is Tween 80; the preservative is eucalyptus oil 80; the antioxidant is sodium metabisulfite; Lidocaine is a topical analgesic. The preparation method of the microcapsules for recovering the sensitivity of drug-resistant bacteria, the preparation method is specifically: 1) at room temperature, the β-galactos...

Embodiment 3

[0018] A microcapsule for recovering the susceptibility of drug-resistant bacteria consists of β-galactosylated azocenediol, ampicillin, lysine reaction product, isopropylthiogalactoside, capsule material, emulsifier, Sweeteners, preservatives, antioxidants and additives are formulated and emulsified; the mass ratio of β-galactosylated azocenediol, ampicillin, isopropylthiogalactoside and lysine is 2:3:2:1; based on the total mass percentage of microcapsules, capsule material is 2.5%, emulsifier is 0.5%, sweetener is 0.03%, preservative is 0.03%, antioxidant is 0.1%, additive 0.25%. The capsule material is sodium alginate; the sweetener is sodium saccharin; the emulsifier is Tween 80; the preservative is eucalyptus oil 80; the antioxidant is sodium metabisulfite; Lidocaine is a topical analgesic. The preparation method of the microcapsules for recovering the sensitivity of drug-resistant bacteria, the preparation method is specifically: 1) at room temperature, the β-galactos...

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Abstract

The invention belongs to the technical field of medicine preparation, and specifically relates to a microcapsule for restoring the sensitivity of drug-resistant bacteria and a preparation method thereof. The microcapsule is composed of β-galactosylated azocenediol, ampicillin, reaction product of lysine and isopropyl thiogalactopyranoside, capsule material, emulsifier, sweetener, preservative, Prepared by emulsification of antioxidants and additives; the mass ratio of β-galactosylated azocenediol, ampicillin, isopropylthiogalactoside and lysine is 1-2:1-6 :1‑4:1‑8; based on the total mass percentage of microcapsules, the capsule material is 1.5%‑3.5%, the emulsifier is 0.1%‑0.5%, the sweetener is 0.03%, and the preservative is 0.01%‑0.05% , Antioxidant is 0.1%-0.2%, additive is 0.25%. Compared with the prior art, the β-galactosylated azocenediol and ampicillin in the microcapsules of the present invention have a stronger synergistic effect, can prevent decomposition, and achieve stable and controllable quality.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and specifically relates to a microcapsule for restoring the sensitivity of drug-resistant bacteria and a preparation method thereof. Background technique [0002] Nitric oxide (NO) is a gaseous small molecular substance with various biological activities. In the body, NO and L-guanidine are produced from NO precursor substance L-arginine under the catalysis of nitric oxide synthase (NOS) and oxygen molecules. NO is ubiquitous in various cells of vertebrates, such as endothelial cells, macrophages, and nerve cells. It is an important regulator of intercellular and intracellular information transmission, and is also a cytotoxic factor in the host immune response. It has been proven to have a variety of biological activities, including regulation of vasodilation and blood flow, nerve signal transmission, signal transduction, immune modulation, redox state of cells, apoptosis of liver ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20
Inventor 陈畅姬金丽黄光美
Owner BEIJING UNIV OF CHEM TECH
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