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Preparation method of rare earth upconversion composite nanomaterial, product and application

A composite nanomaterial and rare earth up-conversion technology, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, and materials for wave energy or particle radiation treatment. It can solve the problems of no PDT preparations and achieve good Biological safety, good possibility of clinical transformation, and efficient killing of tumor cells

Active Publication Date: 2018-08-28
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far there is no PDT formulation based on rare-earth upconversion nanomaterials for tumor-intrinsic stimuli-responsiveness

Method used

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  • Preparation method of rare earth upconversion composite nanomaterial, product and application
  • Preparation method of rare earth upconversion composite nanomaterial, product and application
  • Preparation method of rare earth upconversion composite nanomaterial, product and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1: Synthesis of rare earth up-conversion nanomaterials

[0051] Add 0.5mmol sodium trifluoroacetate, 0.09mmol yttrium trifluoroacetate, 0.4mmol ytterbium trifluoroacetate and 0.01mmol erbium trifluoroacetate to the mixture of 5mmol octadecene and 5mmol oleic acid, under vacuum condition at 120°C Stir to remove water and gas for 10 minutes.

[0052] Subsequently, the reaction solution was injected into a mixture of 5 mmol octadecene and 5 mmol oleic acid at a temperature of 310° C. at a rate of 0.3 mL / min, and reacted for 1 h.

[0053] Subsequently, a mixture of 5 mmol octadecene and 5 mmol oleic acid dissolved in 2 mmol calcium trifluoroacetate was injected twice at 0.3 mL / min, reacted for 30 min, cooled to room temperature, precipitated with ethanol, and centrifuged to obtain rare earth Convert nanomaterials.

[0054] Carry out X-ray diffraction analysis to the obtained rare earth up-conversion nanomaterial, the result is as attached figure 1 shown; the r...

Embodiment 2

[0055] Embodiment 2: Synthesis of Rare Earth Upconversion Nanomaterials

[0056] Add 0.5mmol sodium trifluoroacetate, 0.39mmol yttrium trifluoroacetate, 0.1mmol ytterbium trifluoroacetate and 0.01mmol erbium trifluoroacetate to the mixture of 8mmol octadecene and 8mmol oleic acid, under vacuum condition at 110°C Stir to remove water and air for 20 minutes.

[0057] Subsequently, the reaction solution was injected at a rate of 1 mL / min into a mixture of 8 mmol octadecene and 8 mmol oleic acid at a temperature of 300° C., and reacted for 1.5 h.

[0058] Subsequently, a mixture of 8 mmol octadecene and 8 mmol oleic acid dissolved in 2 mmol calcium trifluoroacetate was injected twice at 1 mL / min, reacted for 20 min, cooled to room temperature, precipitated with ethanol, and centrifuged to obtain rare earth upconversion nanomaterials.

Embodiment 3

[0059] Embodiment 3: Synthesis of rare earth up-conversion nanomaterials

[0060] Add 0.5mmol sodium trifluoroacetate, 0.09mmol yttrium trifluoroacetate, 0.4mmol ytterbium trifluoroacetate and 0.01mmol erbium trifluoroacetate to the mixture of 5mmol octadecene and 5mmol oleic acid, under vacuum condition at 120°C Stir to remove water and gas for 10 minutes.

[0061] Subsequently, the reaction solution was injected into a mixture of 5 mmol octadecene and 5 mmol oleic acid at a temperature of 310° C. at a rate of 0.3 mL / min, reacted for 1 h, cooled to room temperature, precipitated with ethanol, and centrifuged to obtain rare earth upconversion nanomaterials.

[0062] The fluorescence spectra of the rare earth up-conversion nanomaterials obtained in Examples 1 and 3 were measured at 980 nm. The result is as image 3 As shown, the luminescence intensity of rare earth up-conversion nanomaterials is significantly improved after coating with calcium fluoride.

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Abstract

The invention relates to a preparation method of a rare earth upconversion composite nanomaterial, a product and application. The preparation method comprises the following steps that 1, sodium trifluoroacetate, yttrium trifluoroacetate, ytterbium trifluoroacetate and erbium trifluoroacetate are added into mixed liquid of octadecene and oleic acid; water removal and degassing treatment is performed to obtain reaction liquid; 2, then, the reaction liquid is added into the mixed liquid of octadecene and oleic acid at the temperature of 270 to 320 DEG C for reaction; after the separation, the rare earth upconversion nanomaterial is obtained; 3, the rare earth upconversion nanomaterial is subjected to assembly and modification of an amphiphilic macromolecular photosensitizer by an emulsified solvent volatilization method; the rare earth upconversion composite nanomaterial is obtained. The composite material can respond and disintegrate under the stimulation of tumor microenvironment; underthe irradiation of near-infrared light with high tissue penetrating force and through the absorption by the upconversion nanomaterial, a visible light excited photosensitizer molecule is formed through conversion; the photodynamic reaction is generated for killing tumor cells; the selective photodynamic therapy on deep tumor is realized.

Description

technical field [0001] The invention belongs to the field of preparation of composite materials, and in particular relates to a preparation method, product and application of rare earth up-conversion composite nanomaterials. Background technique [0002] Photodynamic therapy (Photodynamic Therapy, PDT) is to inject a photosensitizer (Photosensitizer, Ps) into the human body, and after a certain period of time, irradiate the lesion with light of a specific wavelength, through a series of photochemical and photobiological reactions, with the participation of molecular oxygen , produce reactive oxygen species (ROS), oxidize and destroy various biomacromolecules in tissues and cells, cause irreversible damage to abnormally proliferating cells, and eventually cause cell death to achieve therapeutic purposes. Due to the non-invasive and spatiotemporal response of photodynamic therapy, it has been applied to the clinical treatment of tumors. [0003] In 1976, Kelly and Snell appli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/10A61K47/34A61P35/00
CPCA61K41/0057A61K41/0071A61K47/10A61K47/34
Inventor 凌代舜李方园杜阳
Owner ZHEJIANG UNIV
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