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Application of Yb<3+>-based fluoride nanocrystal as photosensitizer in photodynamic therapy

A technology of photodynamic therapy and photodynamic therapy, which is applied to medical preparations containing active ingredients, drug combinations, wave energy or particle radiation treatment materials, etc., and can solve problems such as poor penetration depth of excitation light.

Active Publication Date: 2016-01-13
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to solve the problem that the excitation light wavelength of the photosensitizer in the traditional photodynamic therapy causes the tissue penetration depth difference of the excitation light in the visible range, and proposes a method based on Yb 3+ Application of Fluoride Nanocrystals as Photosensitizers in Photodynamic Therapy

Method used

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  • Application of Yb&lt;3+&gt;-based fluoride nanocrystal as photosensitizer in photodynamic therapy
  • Application of Yb&lt;3+&gt;-based fluoride nanocrystal as photosensitizer in photodynamic therapy
  • Application of Yb&lt;3+&gt;-based fluoride nanocrystal as photosensitizer in photodynamic therapy

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specific Embodiment approach 1

[0022] Specific implementation mode one: this implementation mode is based on Yb 3+ The application of fluoride nanocrystals as photosensitizers in photodynamic therapy will be based on Yb 3+ The fluoride nanocrystals are used as photosensitizers in photodynamic therapy, wherein the Yb-based 3+ The preparation method of the fluoride nanocrystal is realized according to the following steps:

[0023] 1. At room temperature, YbCl 3 ·6H 2 O joins in the reaction vessel, then adds oleic acid and octadecene, obtains mixed solution;

[0024] 2. Under the protection of Ar gas, heat the mixed solution obtained in step 1 to 160-170°C, stir and keep warm to make YbCl 3 ·6H 2 O is completely dissolved to obtain a reaction solution;

[0025] Three, the molar ratio is 5: (7 ~ 8) NaOH and NH 4 F is added in methanol, stirred to dissolve, obtains raw material liquid;

[0026] 4. Add the raw material solution in step 3 to the reaction solution obtained in step 2, stir and react, then h...

specific Embodiment approach 2

[0030] Specific embodiment two: the difference between this embodiment and specific embodiment one is that step one YbCl 3 ·6H 2 The molar amount of O to the volume ratio of oleic acid is 1mmol: 6ml, YbCl 3 ·6H 2 The volume ratio of the molar amount of O to octadecene is 1 mmol: 15 ml. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0031] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that the stirring speed in step 2 is 300-500 r / min. Other steps and parameters are the same as those in Embodiment 1 or Embodiment 2.

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Abstract

The invention relates to application of an Yb<3+>-based fluoride nanocrystal as a photosensitizer in a photodynamic therapy and belongs to the field of the photodynamic therapy. According to the application, the problem of poor tissue penetration depth of exciting light caused by the wavelength of the exciting light of the photosensitizer in a visible region rang in the traditional photodynamic therapy is solved. The Yb<3+>-based fluoride nanocrystal is used as the photosensitizer to be applied to the photodynamic therapy. A preparation method of the Yb<3+>-based fluoride nanocrystal comprises the following steps: (1) adding YbCl3.6H2O into oleic acid and octadecene; (2) heating and dissolving; (3) adding NaOH and NH4F into methanol; (4) heating to react after mixing and water removal; (5) collecting NaYbF4 nanocrystals; (6) carrying out bond linking with Tween; and (7) carrying out bond linking with folic acid. According to the application, by irradiating by virtue of a light source with the wavelength of about 1 micron, deep tissue solid tumors can be treated by virtue of the wavelength in a biological tissue penetration window range.

Description

technical field [0001] The invention belongs to the field of photodynamic therapy, in particular to a Yb-based 3+ Application of fluoride nanocrystals in near-infrared photodynamic therapy. Background technique [0002] Photodynamic therapy is a minimally invasive tumor treatment method that involves three basic elements: photosensitizer, excitation light and oxygen. When light of a specific wavelength irradiates the photosensitizer, the photosensitizer is excited, and the photosensitizer in the excited state undergoes a photochemical reaction with oxygen, converting oxygen into reactive oxygen species, causing irreversible tumor tissue damage. Compared with traditional chemotherapy, surgery and radiotherapy, PDT has several potential advantages: relatively non-invasive treatment, can accurately locate the target tumor tissue, repeatable treatment, relatively convenient operation and minimal side effects, etc. However, for traditional PDT, the excitation light wavelength o...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P35/00
Inventor 张治国张佳音秦峰赵华郑仰东
Owner HARBIN INST OF TECH
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