Application of Yb<3+>-based fluoride nanocrystal as photosensitizer in photodynamic therapy

A technology of photodynamic therapy and photodynamic therapy, which is applied to medical preparations containing active ingredients, drug combinations, wave energy or particle radiation treatment materials, etc., and can solve problems such as poor penetration depth of excitation light.

Active Publication Date: 2016-01-13
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to solve the problem that the excitation light wavelength of the photosensitizer in the traditional photodynamic therapy causes the tissue pen

Method used

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  • Application of Yb&lt;3+&gt;-based fluoride nanocrystal as photosensitizer in photodynamic therapy
  • Application of Yb&lt;3+&gt;-based fluoride nanocrystal as photosensitizer in photodynamic therapy
  • Application of Yb&lt;3+&gt;-based fluoride nanocrystal as photosensitizer in photodynamic therapy

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Example Embodiment

[0022] Specific embodiment 1: This embodiment is based on Yb 3+ The application of fluoride nanocrystals as photosensitizers in photodynamic therapy is based on Yb 3+ The fluoride nanocrystals are used as photosensitizers in photodynamic therapy, which are based on Yb 3+ The preparation method of fluoride nanocrystals is realized by the following steps:

[0023] 1. Put YbCl at room temperature 3 ·6H 2 O was added to the reaction vessel, and then oleic acid and octadecene were added to obtain a mixed liquid;

[0024] 2. Under the protection of Ar gas, heat the mixture obtained in step 1 to 160~170℃, stir and keep warm to make YbCl 3 ·6H 2 O is completely dissolved to obtain a reaction liquid;

[0025] 3. The massage ratio is 5: (7~8) NaOH and NH 4 F was added to methanol, stirred until dissolved to obtain a raw material liquid;

[0026] 4. Add the raw material liquid of step 3 to the reaction liquid obtained in step 2, stir the reaction and then raise the temperature to 80°C, wait until...

Example Embodiment

[0030] Specific embodiment two: this embodiment is different from specific embodiment one in step one YbCl 3 ·6H 2 The molar ratio of O to the volume of oleic acid is 1mmol: 6ml, YbCl 3 ·6H 2 The molar ratio of O to the volume of octadecene is 1 mmol: 15 ml. Other steps and parameters are the same as in the first embodiment.

Example Embodiment

[0031] Specific embodiment three: This embodiment is different from specific embodiment one or two in that the stirring speed in step two is 300-500 r / min. Other steps and parameters are the same as those in the first or second embodiment.

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Abstract

The invention relates to application of an Yb<3+>-based fluoride nanocrystal as a photosensitizer in a photodynamic therapy and belongs to the field of the photodynamic therapy. According to the application, the problem of poor tissue penetration depth of exciting light caused by the wavelength of the exciting light of the photosensitizer in a visible region rang in the traditional photodynamic therapy is solved. The Yb<3+>-based fluoride nanocrystal is used as the photosensitizer to be applied to the photodynamic therapy. A preparation method of the Yb<3+>-based fluoride nanocrystal comprises the following steps: (1) adding YbCl3.6H2O into oleic acid and octadecene; (2) heating and dissolving; (3) adding NaOH and NH4F into methanol; (4) heating to react after mixing and water removal; (5) collecting NaYbF4 nanocrystals; (6) carrying out bond linking with Tween; and (7) carrying out bond linking with folic acid. According to the application, by irradiating by virtue of a light source with the wavelength of about 1 micron, deep tissue solid tumors can be treated by virtue of the wavelength in a biological tissue penetration window range.

Description

technical field [0001] The invention belongs to the field of photodynamic therapy, in particular to a Yb-based 3+ Application of fluoride nanocrystals in near-infrared photodynamic therapy. Background technique [0002] Photodynamic therapy is a minimally invasive tumor treatment method that involves three basic elements: photosensitizer, excitation light and oxygen. When light of a specific wavelength irradiates the photosensitizer, the photosensitizer is excited, and the photosensitizer in the excited state undergoes a photochemical reaction with oxygen, converting oxygen into reactive oxygen species, causing irreversible tumor tissue damage. Compared with traditional chemotherapy, surgery and radiotherapy, PDT has several potential advantages: relatively non-invasive treatment, can accurately locate the target tumor tissue, repeatable treatment, relatively convenient operation and minimal side effects, etc. However, for traditional PDT, the excitation light wavelength o...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P35/00
Inventor 张治国张佳音秦峰赵华郑仰东
Owner HARBIN INST OF TECH
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