Hyaluronic acid flushing fluid for nasal cavity as well as preparation method and application of hyaluronic acid flushing fluid

A hyaluronic acid and nasal irrigation technology, applied in the field of medicine, can solve the problems of speeding up the recovery of patients with nasal cavity, affecting the recovery of patients with rhinitis or nasal cavity surgery, not having moisturizing and repairing effects, etc. effect of flushing

Inactive Publication Date: 2015-12-16
NANJING TZONE BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, most nasal irrigation agents in the market are mainly salt water. Saline irrigation can only remove pathogenic bacteria and dirt. It does not have the effect of moisturizing and repairing the damaged nasal mucosa caused by nasal inflammation, which will affect rhinitis or nasal cavity. For the recovery of surgical patients, the invention can speed up the recovery of nasal cavity patients by adding hyaluronic acid, a raw material with moisturizing and repairing effects, into the nasal cavity rinse, which has very important significance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A hyaluronic acid nasal rinse, comprising the following components in mass percentage: 0.06% middle molecular weight hyaluronic acid, 0.03% small molecular weight hyaluronic acid, 2.0% sodium chloride, 0.01% peppermint extract, 0.06% Tween 80 , 0.01% potassium chloride, 0.02% calcium chloride, 0.02% magnesium chloride, and the balance is distilled water.

[0042] Medium molecular weight hyaluronic acid has a molecular weight of 1.0×106 Da; the molecular weight of small molecular weight hyaluronic acid is 5000.

[0043] The preparation method of the above-mentioned hyaluronic acid nasal rinse solution comprises the following steps:

[0044] Step 1: Add Tween 80 to the required distilled water, stir evenly at room temperature at a stirring speed of 500r / min, and use it as the first component;

[0045] Step 2: add peppermint extract into component 1 at room temperature, stir evenly at a stirring speed of 500r / min, and use it as the second component;

[0046] Step 3: Spri...

Embodiment 2

[0049] A hyaluronic acid nasal rinse, comprising the following components in mass percentage: 0.06% medium molecular weight hyaluronic acid, 0.03% small molecular weight hyaluronic acid, 0.9% sodium chloride, 0.008% peppermint extract, 0.4% Tween 80 , 0.05% potassium chloride, 0.04% calcium chloride, 0.03% magnesium chloride, and the balance is distilled water.

[0050] The molecular weight of medium molecular weight hyaluronic acid is 1.4×10 6 Da; the molecular weight of small molecular weight hyaluronic acid is 3000.

[0051] The preparation method of the above-mentioned hyaluronic acid nasal rinse solution comprises the following steps:

[0052] Step 1: Add Tween 80 into the required distilled water, stir evenly at room temperature at a stirring speed of 550r / min, and use it as the first component;

[0053] Step 2: Add the peppermint extract into component 1 at room temperature, stir evenly at a stirring speed of 550r / min, and use it as the second component;

[0054] Ste...

Embodiment 3

[0057] A hyaluronic acid nasal rinse, comprising the following components in mass percentage: 0.08% middle molecular weight hyaluronic acid, 0.04% small molecular weight hyaluronic acid, 0.9% sodium chloride, 0.009% peppermint extract, 0.2% Tween 80 , 0.05% potassium chloride, 0.05% calcium chloride, 0.03% magnesium chloride, and the balance is distilled water.

[0058] Medium molecular weight hyaluronic acid has a molecular weight of 1.5×10 6 Da; the molecular weight of small molecular weight hyaluronic acid is 4800.

[0059] The preparation method of the above-mentioned hyaluronic acid nasal rinse solution comprises the following steps:

[0060] Step 1: Add Tween 80 into the required distilled water, stir evenly at room temperature at a stirring speed of 480r / min, and use it as the first component;

[0061] Step 2: Add the peppermint extract into component 1 at room temperature, stir evenly at a stirring speed of 480r / min, and use it as the second component;

[0062] Step...

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PUM

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Abstract

The invention relates to hyaluronic acid flushing fluid for the nasal cavity as well as a preparation method and an application of the hyaluronic acid flushing fluid. The hyaluronic acid flushing fluid is prepared from the following components in percentage by weight: 0.01-0.3% of middle-molecular-weight hyaluronic acid, 0.01-0.3% of small-molecular-weight hyaluronic acid, 0.9-5.0% of sodium chloride, 0.005-0.1% of mint extract, 0.01-0.07% of potassium chloride, 0.02-0.08% of calcium chloride, 0.01-0.1% of magnesium chloride, and the balance of distilled water. The hyaluronic acid flushing fluid for the nasal cavity has the efficacies of preserving moisture, repairing, diminishing inflammation, and flushing, and is suitable for daily care for the nasal cavity, the adjuvant therapy for acute and chronic rhinitis, and nasosinusitis, as well as the chemotherapy and postoperative care for the nasal cavity.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a hyaluronic acid nasal rinse solution and its preparation method and application. Background technique [0002] In daily life, upper respiratory tract infection, immune response, nasal polyps, and air pollution can all cause irritation to the nasal mucosa and cause edema or ciliary dysfunction. When the nasal mucosa and cilia cannot effectively remove secretions, it will lead to acute sinusitis. Clinically, antibiotics, antihistamines, and topical glucocorticoids are commonly used to treat sinusitis in order to reduce inflammation and reduce congestion. However, the above measures sometimes cannot quickly relieve the symptoms of patients with sinusitis. As an effective supportive therapy, bilateral nasal cavity irrigation (nasalirrigation) has been widely used in the treatment of nasal cavity and sinuses, and has been accepted by more and more clinicians. It is important to note that in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/534A61P11/02
Inventor 徐林金玉
Owner NANJING TZONE BIOLOGICAL SCI & TECH
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