Preparation method of rare earth fluoride/poly-azobenzene/N-isopropyl acrylamide composite multifunctional nano-particles
A technology of isopropylacrylamide and propylacrylamide, which is applied in the field of preparation of rare earth fluoride/polyazobenzene/N-isopropylacrylamide composite multifunctional nanoparticles, can solve the problem of on-demand delivery of difficult drugs Controlled release, load limitation, poor therapeutic effect, etc., to achieve the effect of improving solubility, increasing stability, and satisfying luminescence performance
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0028] A preparation method of rare earth fluoride / polyazobenzene / N-isopropylacrylamide composite multifunctional nanoparticles. The composite nanoparticle has an egg yolk structure, and the core is a homogeneous core-shell rare earth nanoparticle. Its chemical formula is: NaYF 4 : Tm 3+ , Yb 3+ ,Tm 3+ / NaYF 4 , the shell is a PNIPAM shell (PAZO-NIPAM @UCNPs) with BMAAB as a crosslinking agent, the core size is 40 nm; the shell thickness is 60 nm, and its preparation includes the following steps:
[0029] (1) 20%Yb 3+ / 0.5%Tm 3+ Preparation of upconverting nanoparticles: 15 mL of 1-octadecene (ODE), 7 mL of oleic acid (OA), 3.975 mL of yttrium chloride (YCl 3 ) aqueous solution (0.2mol / L), 1 mL ytterbium chloride (YbCl 3 ) aqueous solution (0.2mol / L) and 25 µL thulium chloride (TmCl 3 ) aqueous solution (0.1mol / L), heated up to 120 °C under nitrogen flow, removed the moisture and oxygen in the system, then raised the temperature to 150 °C, kept it warm for 50 min, then...
Embodiment 2
[0035] (1) 20%Yb 3+ / 0.5%Tm 3+ Preparation of upconverting nanoparticles: 10 mL of 1-octadecene (ODE), 5 mL of oleic acid (OA), 1 mL of yttrium chloride (YCl 3 ) aqueous solution (0.2mol / L), 1 mL ytterbium chloride (YbCl 3 ) aqueous solution (0.2mol / L) and 10 µL thulium chloride (TmCl 3 ) aqueous solution (0.1mol / L), heated up to 110 °C under nitrogen flow, removed the moisture and oxygen in the system, then raised the temperature to 140 °C, kept it warm for 45 min, then cooled it, and added 5 mL of sodium hydroxide methanol solution (0.5 mol / L) and 8mL methanolic ammonium fluoride solution (0.5mol / L), stirred at room temperature for 1 h; heated to 100 °C to remove methanol and moisture, then raised to 290 °C, kept warm for 60 min, cooled to room temperature, added 7 The product was precipitated with mL of ethanol, and the mixed solution was centrifuged at 5000 rpm for 10 min, washed with ethanol three times, and the product was dispersed in 10 mL of chloroform for use.
...
Embodiment 3
[0041] (1) 20%Yb 3+ / 0.5%Tm 3+ Preparation of upconverting nanoparticles: 20 mL of 1-octadecene (ODE), 10 mL of oleic acid (OA), 5 mL of yttrium chloride (YCl 3 ) aqueous solution (0.2mol / L), 4 mL ytterbium chloride (YbCl 3 ) aqueous solution (0.2mol / L) and 30 µL thulium chloride (TmCl 3 ) aqueous solution (0.1mol / L), heated up to 120 °C under nitrogen flow, removed the moisture and oxygen in the system, then raised the temperature to 160 °C, kept it warm for 55 min, then cooled it, and added 7 mL of sodium hydroxide methanol solution (0.5 mol / L) and 10 mL ammonium fluoride methanol solution (0.5mol / L), stirred at room temperature for 2 h; heated to 150 °C to remove methanol and water, then heated to 300 °C, kept for 90 min, cooled to room temperature, added The product was precipitated with 13 mL of ethanol, and the mixed solution was centrifuged at 10,000 rpm for 20 min. After washing with ethanol three times, the product was dispersed in 15 mL of chloroform for use.
[...
PUM
Property | Measurement | Unit |
---|---|---|
thickness | aaaaa | aaaaa |
particle diameter | aaaaa | aaaaa |
particle diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com