Preparation method of rare earth fluoride/poly-azobenzene/N-isopropyl acrylamide composite multifunctional nano-particles

A technology of isopropylacrylamide and propylacrylamide, which is applied in the field of preparation of rare earth fluoride/polyazobenzene/N-isopropylacrylamide composite multifunctional nanoparticles, can solve the problem of on-demand delivery of difficult drugs Controlled release, load limitation, poor therapeutic effect, etc., to achieve the effect of improving solubility, increasing stability, and satisfying luminescence performance

Inactive Publication Date: 2018-06-12
HUBEI UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the loading of drugs on mesoporous channels will limit the loading capacity, it is difficult to achieve on-demand and controlled release of drugs, and the therapeutic effect is not good

Method used

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  • Preparation method of rare earth fluoride/poly-azobenzene/N-isopropyl acrylamide composite multifunctional nano-particles
  • Preparation method of rare earth fluoride/poly-azobenzene/N-isopropyl acrylamide composite multifunctional nano-particles
  • Preparation method of rare earth fluoride/poly-azobenzene/N-isopropyl acrylamide composite multifunctional nano-particles

Examples

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Embodiment 1

[0028] A preparation method of rare earth fluoride / polyazobenzene / N-isopropylacrylamide composite multifunctional nanoparticles. The composite nanoparticle has an egg yolk structure, and the core is a homogeneous core-shell rare earth nanoparticle. Its chemical formula is: NaYF 4 : Tm 3+ , Yb 3+ ,Tm 3+ / NaYF 4 , the shell is a PNIPAM shell (PAZO-NIPAM @UCNPs) with BMAAB as a crosslinking agent, the core size is 40 nm; the shell thickness is 60 nm, and its preparation includes the following steps:

[0029] (1) 20%Yb 3+ / 0.5%Tm 3+ Preparation of upconverting nanoparticles: 15 mL of 1-octadecene (ODE), 7 mL of oleic acid (OA), 3.975 mL of yttrium chloride (YCl 3 ) aqueous solution (0.2mol / L), 1 mL ytterbium chloride (YbCl 3 ) aqueous solution (0.2mol / L) and 25 µL thulium chloride (TmCl 3 ) aqueous solution (0.1mol / L), heated up to 120 °C under nitrogen flow, removed the moisture and oxygen in the system, then raised the temperature to 150 °C, kept it warm for 50 min, then...

Embodiment 2

[0035] (1) 20%Yb 3+ / 0.5%Tm 3+ Preparation of upconverting nanoparticles: 10 mL of 1-octadecene (ODE), 5 mL of oleic acid (OA), 1 mL of yttrium chloride (YCl 3 ) aqueous solution (0.2mol / L), 1 mL ytterbium chloride (YbCl 3 ) aqueous solution (0.2mol / L) and 10 µL thulium chloride (TmCl 3 ) aqueous solution (0.1mol / L), heated up to 110 °C under nitrogen flow, removed the moisture and oxygen in the system, then raised the temperature to 140 °C, kept it warm for 45 min, then cooled it, and added 5 mL of sodium hydroxide methanol solution (0.5 mol / L) and 8mL methanolic ammonium fluoride solution (0.5mol / L), stirred at room temperature for 1 h; heated to 100 °C to remove methanol and moisture, then raised to 290 °C, kept warm for 60 min, cooled to room temperature, added 7 The product was precipitated with mL of ethanol, and the mixed solution was centrifuged at 5000 rpm for 10 min, washed with ethanol three times, and the product was dispersed in 10 mL of chloroform for use.

...

Embodiment 3

[0041] (1) 20%Yb 3+ / 0.5%Tm 3+ Preparation of upconverting nanoparticles: 20 mL of 1-octadecene (ODE), 10 mL of oleic acid (OA), 5 mL of yttrium chloride (YCl 3 ) aqueous solution (0.2mol / L), 4 mL ytterbium chloride (YbCl 3 ) aqueous solution (0.2mol / L) and 30 µL thulium chloride (TmCl 3 ) aqueous solution (0.1mol / L), heated up to 120 °C under nitrogen flow, removed the moisture and oxygen in the system, then raised the temperature to 160 °C, kept it warm for 55 min, then cooled it, and added 7 mL of sodium hydroxide methanol solution (0.5 mol / L) and 10 mL ammonium fluoride methanol solution (0.5mol / L), stirred at room temperature for 2 h; heated to 150 °C to remove methanol and water, then heated to 300 °C, kept for 90 min, cooled to room temperature, added The product was precipitated with 13 mL of ethanol, and the mixed solution was centrifuged at 10,000 rpm for 20 min. After washing with ethanol three times, the product was dispersed in 15 mL of chloroform for use.

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Abstract

The invention provides a preparation method of rare earth fluoride/poly-azobenzene/N-isopropyl acrylamide composite multifunctional nano-particles. The composite multifunctional nano-particle is provided with a yolk structure, and has the intelligent response characteristic due to the dual-responsiveness of a shell layer; the yolk structure enables the nano-particle has sufficient storage space, thereby realizing the effective load and controllable release of the anti-tumor medicine. The method comprises the following steps: 1) synthesis of homogeneous rare earth nuclear shell nano-particle; 2) cladding a silica layer with shell layer thickness of about 15nm through a reverse micro-emulsion method; 3) preparing dual-responsive shell by taking photo-responsive azobenzene as crosslinking agent and N-isopropyl acrylamide as the monomer; and 4) preparing the multifunctional nano-particle of the yolk structure with inner core as the rare earth nano-particle and the shell as the dual-responsive shell layer through a HF etching silica layer. The multifunctional rare earth nano-particle provided by the invention can be applied in the biological medicine field to a certain degree.

Description

technical field [0001] The invention relates to a preparation technology of rare earth fluoride / polyazobenzene / N-isopropylacrylamide composite multifunctional nano particles, and is a preparation method of a nano carrier with a special egg yolk structure. Background technique [0002] With the development of smart material research, upconversion nanoluminescent materials have been widely studied because of their unique optical and physical properties. Upconversion luminescent materials are a class of materials with upconversion luminescence properties. Upconversion Luminescence (UCL) is an anti-Stokes process, which means that rare earth particles continuously absorb multiple low-energy long-wavelength photons and convert low-energy photons to The process of converting to high-energy short-wavelength photons. The luminescence process uses near-infrared light for excitation, and near-infrared light has obvious advantages over high-energy light sources. It has strong tissue p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/85B82Y20/00B82Y30/00A61K47/04A61K47/34A61K49/00
CPCA61K47/02A61K47/34A61K49/0013A61K49/0093B82Y20/00B82Y30/00C09K11/02C09K11/7773
Inventor 王小涛刘小平叶晓铁
Owner HUBEI UNIV OF TECH
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