Preparation method of rare earth fluoride/poly-azobenzene/N-isopropyl acrylamide composite multifunctional nano-particles

A technology of isopropylacrylamide and propylacrylamide, which is applied in the field of preparation of rare earth fluoride/polyazobenzene/N-isopropylacrylamide composite multifunctional nanoparticles, can solve the problem of on-demand delivery of difficult drugs Controlled release, load limitation, poor therapeutic effect, etc., to achieve the effect of improving solubility, increasing stability, and satisfying luminescence performance
CN108148570AInactive Publication Date: 2018-06-12HUBEI UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUBEI UNIV OF TECH
Publication Date
2018-06-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a preparation method of rare earth fluoride / poly-azobenzene / N-isopropyl acrylamide composite multifunctional nano-particles. The composite multifunctional nano-particle is provided with a yolk structure, and has the intelligent response characteristic due to the dual-responsiveness of a shell layer; the yolk structure enables the nano-particle has sufficient storage space, thereby realizing the effective load and controllable release of the anti-tumor medicine. The method comprises the following steps: 1) synthesis of homogeneous rare earth nuclear shell nano-particle; 2) cladding a silica layer with shell layer thickness of about 15nm through a reverse micro-emulsion method; 3) preparing dual-responsive shell by taking photo-responsive azobenzene as crosslinking agent and N-isopropyl acrylamide as the monomer; and 4) preparing the multifunctional nano-particle of the yolk structure with inner core as the rare earth nano-particle and the shell as the dual-responsive shell layer through a HF etching silica layer. The multifunctional rare earth nano-particle provided by the invention can be applied in the biological medicine field to a certain degree.
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Description

technical field

[0001] The invention relates to a preparation technology of rare earth fluoride / polyazobenzene / N-isopropylacrylamide composite multifunctional nano particles, and is a preparation method of a nano carrier with a special egg yolk structure. Background technique

[0002] With the development of smart material research, upconversion nanoluminescent materials have been widely studied because of their unique optical and physical properties. Upconversion luminescent materials are a class of materials with upconversion luminescence properties. Upconversion Luminescence (UCL) is an anti-Stokes process, which means that rare earth particles continuously absorb multiple low-energy long-wavelength photons and convert low-energy photons to The process of converting to high-energy short-wavelength photons. The luminescence process uses near-infrared light for excitation, and near-infrared light has obvious advantages over high-energy light sources. It has strong tissue p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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