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Method for preparing medicine carryed nanometer particle of polycyanoacrylate

The technology of polycyanoacrylate and cyanoacrylate is applied in the field of preparation of polycyanoacrylate drug-loaded nanoparticles, which can solve the problems of limited drug-loading rate of loaded hydrophobic drugs and the like, and achieves improved coating rate, The effect of high drug loading

Inactive Publication Date: 2007-10-03
YOUSHUN CHEM TAISHAN CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the above method is still limited to improve the drug loading rate of PACA particles loaded with hydrophobic drugs.

Method used

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  • Method for preparing medicine carryed nanometer particle of polycyanoacrylate
  • Method for preparing medicine carryed nanometer particle of polycyanoacrylate
  • Method for preparing medicine carryed nanometer particle of polycyanoacrylate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: the n-butyl cyanoacrylate nanoparticle of loaded paclitaxel

[0021]Paclitaxel is extracted from the bark of Pacific yew (Taxus brevifolia), and is a highly hydrophobic anticancer drug. At present, the drug is facing two main problems to be overcome and improved in clinical application. The first is the source of paclitaxel. Since this drug is extracted from the bark of the yew tree which is rare and grows slowly, how to obtain a larger amount of paclitaxel from other methods is one of the problems that must be solved. Another problem is how to improve the injection formulation for administration. Since the solubility of highly hydrophobic paclitaxel in water is less than 3 μg / ml, it cannot be dissolved in a large amount in aqueous solution. Therefore, it cannot be directly dissolved in aqueous solution for intravenous injection. . At present, the injection formula used in actual clinical use is to dissolve paclitaxel in a solution mixed with ethanol and...

Embodiment 2

[0063] Example 2: Poly(n-butyl cyanoacrylate) nanoparticles loaded with flutamide

[0064] Flutamide is an anti-prostate cancer drug, which is also a highly hydrophobic drug.

[0065] In this example, after dissolving flutamide in BCA monomer, the BCA monomer solution containing flutamide was dispersed in the surfactant Pluronic F68 [poly(ethyleneoxide)-poly (propylene oxide)-poly(ethylene oxide); MW 8,400Da] acidic aqueous solution to prepare PBCA nano drug-loaded particles loaded with flutamide. The concentration of surfactant F68 in the acidic solution was 0.5%, and other preparation conditions were the same as in Example 1. The effect of the content of flutamide in the BCA monomer on the properties of the obtained drug-loaded particles is shown in Table 3.

[0066] Flutamide content

Flutamide

content

(%, w / w)

The average particle size

Average

diameter±S.D.

(nm)

particle size dispersion

Polydispersity

particle ...

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Abstract

A medicine carried polycyanoacrylate nanoparticle as medicine carrier with high covering percentage is prepared through dissolving medicine in the cyanoacrylate monomers, and fine emulsion polymerizing reaction.

Description

technical field [0001] The invention relates to a preparation method of polymer drug-loaded nanoparticles, in particular to a preparation method of drug-loaded polycyanoacrylate drug-loaded nanoparticles. Background technique [0002] In the past decades, the research on biodegradable poly(alkyl cyanoacrylates); PACAs nanoparticles as drug-loaded particles found that this material can be prepared to load many different types of drugs, such as Anticancer drugs, antibiotics, peptides and genes, etc., and can effectively prolong and control the release time of the loaded drugs, and can carry the loaded drugs into the tissues or organs to be treated for release. [0003] The general method for preparing PACA particles is to add cyanoacrylic acid monomers into an acidic aqueous solution containing a surfactant, and use emulsion polymerization or dispersion polymerization to synthesize drug-loaded particles. There are two ways to coat drugs with PACA. One is to pre-dissolve the d...

Claims

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Application Information

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IPC IPC(8): A61K47/32
Inventor 李育德黄基毓陈志鸣
Owner YOUSHUN CHEM TAISHAN CITY
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