Embolic microspheres containing ion exchange functional groups

A technology of ion exchange and functional groups, which is applied in the field of preparation of embolic microspheres, can solve the problems of cumbersome preparation process and low drug loading, and achieve the effects of simplified preparation methods, large drug loading, and good stability
CN104258474AInactive Publication Date: 2015-01-07嘉兴嘉湖骨科医院管理有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
嘉兴嘉湖骨科医院管理有限公司
Publication Date
2015-01-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of embolic microspheres containing ion exchange functional groups. According to the preparation method, AMPS (2-acrylamide-2-methylpro panesulfonic acid) is prepared into a mild crosslinking prepolymer and then blended with SA (sodium alginate), a PAMPS and SA polymer blend solution is added into liquid paraffin, interpenetrating polymer network microspheres prepared with a reversed phase suspension crosslinking method are in regular spherical shape, the particle sizes range between 300 microns and 700 microns in a concentrated manner, the drug loading rate of the microspheres can be 25%-45%, the performance after high temperature sterilization and sealing is stable, and the embolic microspheres have application prospect in anti-tumor embolism chemotherapy.
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Description

technical field

[0001] The invention discloses the preparation of embolism microspheres containing ion-exchange functional groups, and belongs to the field of medical material preparation. Background technique

[0002] Sodium alginate (SA) is a natural polysaccharide composed of D-glucuronic acid and D-guluronic acid, which has the characteristics of good biocompatibility, non-toxicity and degradability. Among them, guluronic acid is easily combined with Ca 2+ 、Ba 2+ Waiting for the metal divalent ions to form electrostatic interaction, cross-linking to obtain sodium alginate microspheres. Based on the above characteristics, sodium alginate is widely used in the food and pharmaceutical industries.

[0003] The efficacy of traditional transarterial chemoembolization in the treatment of advanced liver cancer has been recognized. After the embolic agent is injected into the hepatic artery through the catheter, it will block the capillaries around the cancer cells, block the...

Claims

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