Embolic microspheres containing ion exchange functional groups

A technology of ion exchange and functional groups, which is applied in the field of preparation of embolic microspheres, can solve the problems of cumbersome preparation process and low drug loading, and achieve the effects of simplified preparation methods, large drug loading, and good stability

Inactive Publication Date: 2015-01-07
嘉兴嘉湖骨科医院管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the traditional vascular embolic agents cannot be loaded with chemotherapy drugs and can only serve the purpose of physical embolism, which has certain limitations in clinical application. Although some drug-loaded microspheres have been reported in domestic and foreign literature in recent years, most of them have passed Physical embedding of loaded drugs has disadvantages such as low drug loading and cumbersome preparation process. At present, in the United States, the only commercially available drug-loaded elution microspheres are non-biodegradable DC beads, which are composed of PVA hydrogel.

Method used

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  • Embolic microspheres containing ion exchange functional groups
  • Embolic microspheres containing ion exchange functional groups
  • Embolic microspheres containing ion exchange functional groups

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of the embolization microsphere that contains ion-exchange functional group

[0016] (1) Synthetic poly 2-acrylamide-2-methylpropanesulfonic acid prepolymer, the AMPS of 0.5g is dissolved in deionized water and forms the aqueous solution of 0.5w%, adds polyethylene glycol dimethacrylate (0.065 w%) as a mild cross-linking reagent, potassium persulfate (0.020w%) is an initiator, stirred and dissolved and mixed uniformly, heated in a water bath to 70°C, and reacted for 5 hours to form a viscous fluid prepolymer. The polymer solution was dropped into the ether solution to precipitate, after three times of dissolution-reprecipitation, and finally vacuum-dried to obtain the pure polymer PAMPS;

[0017] (2) Prepare a blended polymer solution, dissolve sodium alginate in deionized water to form a 1.5w% solution, add pure polymer PAMPS to deionized water to form a 2w% solution, according to the mass ratio of PAMPS to SA is 1 :1~1:8 Mix the two comp...

Embodiment 2

[0019] Example 2: Activation of the Ion Exchange Group of Embolization Microspheres

[0020] After drying the embolism microspheres prepared in Example 1, re-immerse them in 8-10w% hydrochloric acid solution and stir for half an hour, filter the microspheres, repeatedly soak and wash with deionized water to remove residual hydrochloric acid, and vacuum-dry to obtain Final product.

Embodiment 3

[0021] Embodiment 3: Optical microscope pictures and particle size distribution of microspheres

[0022] Take the dried embolization microspheres containing ion-exchange functional groups on a glass slide, adjust the magnification of the optical microscope so that there are as many microspheres as possible in one field of view, and observe the surface morphology of the microspheres to further accurately Measure the particle size of the microspheres and observe their distribution trend.

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Abstract

The invention discloses a preparation method of embolic microspheres containing ion exchange functional groups. According to the preparation method, AMPS (2-acrylamide-2-methylpro panesulfonic acid) is prepared into a mild crosslinking prepolymer and then blended with SA (sodium alginate), a PAMPS and SA polymer blend solution is added into liquid paraffin, interpenetrating polymer network microspheres prepared with a reversed phase suspension crosslinking method are in regular spherical shape, the particle sizes range between 300 microns and 700 microns in a concentrated manner, the drug loading rate of the microspheres can be 25%-45%, the performance after high temperature sterilization and sealing is stable, and the embolic microspheres have application prospect in anti-tumor embolism chemotherapy.

Description

technical field [0001] The invention discloses the preparation of embolism microspheres containing ion-exchange functional groups, and belongs to the field of medical material preparation. Background technique [0002] Sodium alginate (SA) is a natural polysaccharide composed of D-glucuronic acid and D-guluronic acid, which has the characteristics of good biocompatibility, non-toxicity and degradability. Among them, guluronic acid is easily combined with Ca 2+ 、Ba 2+ Waiting for the metal divalent ions to form electrostatic interaction, cross-linking to obtain sodium alginate microspheres. Based on the above characteristics, sodium alginate is widely used in the food and pharmaceutical industries. [0003] The efficacy of traditional transarterial chemoembolization in the treatment of advanced liver cancer has been recognized. After the embolic agent is injected into the hepatic artery through the catheter, it will block the capillaries around the cancer cells, block the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/16
Inventor 倪才华刘明张丽萍杨期颐奚林陶蕾谭骏
Owner 嘉兴嘉湖骨科医院管理有限公司
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