Embolic microspheres containing ion exchange functional groups

Abstract

The invention discloses a preparation method of embolic microspheres containing ion exchange functional groups. According to the preparation method, AMPS (2-acrylamide-2-methylpro panesulfonic acid) is prepared into a mild crosslinking prepolymer and then blended with SA (sodium alginate), a PAMPS and SA polymer blend solution is added into liquid paraffin, interpenetrating polymer network microspheres prepared with a reversed phase suspension crosslinking method are in regular spherical shape, the particle sizes range between 300 microns and 700 microns in a concentrated manner, the drug loading rate of the microspheres can be 25%-45%, the performance after high temperature sterilization and sealing is stable, and the embolic microspheres have application prospect in anti-tumor embolism chemotherapy.

Description

technical field [0001] The invention discloses the preparation of embolism microspheres containing ion-exchange functional groups, and belongs to the field of medical material preparation. Background technique [0002] Sodium alginate (SA) is a natural polysaccharide composed of D-glucuronic acid and D-guluronic acid, which has the characteristics of good biocompatibility, non-toxicity and degradability. Among them, guluronic acid is easily combined with Ca 2+ 、Ba 2+ Waiting for the metal divalent ions to form electrostatic interaction, cross-linking to obtain sodium alginate microspheres. Based on the above characteristics, sodium alginate is widely used in the food and pharmaceutical industries. [0003] The efficacy of traditional transarterial chemoembolization in the treatment of advanced liver cancer has been recognized. After the embolic agent is injected into the hepatic artery through the catheter, it will block the capillaries around the cancer cells, block the...

AI Technical Summary

Problems solved by technology

[0004] Most of the traditional vascular embolic agents cannot be loaded with chemotherapy drugs and can only serve the purpose of physical embolism, which has certain limitations in clinical application. Although some drug-loaded microspheres have been reported in domestic and foreign literature in recent years, most of them have passed Physical embedding of loaded drugs has disadvantages such as low drug loading and cumbersome preparation process. At present, in the United States, the only commercially available drug-loaded elution microspheres are non-biodegradable DC beads, which are composed of PVA hydrogel.

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