Self-setting calcium phosphate micro spheres, method for preparing same and application thereof

A calcium phosphate microsphere, self-curing technology, used in dental preparations, pharmaceutical formulations, medical science and other directions, can solve the problem of inability to combine the anti-disintegration and degradability of microspheres at the same time, and achieve good bone defect repair and performance. Therapeutic effect, good biodegradability and non-toxic effect

Inactive Publication Date: 2010-10-06
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The primary purpose of the present invention is to overcome the shortcomings and deficiencies that the Ca-P salt microspheres in the prior art cannot combine the disintegration resistance and degradability of the microspheres well, and provide a self-curing calcium phosphate microsphere Ball Preparation Method

Method used

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  • Self-setting calcium phosphate micro spheres, method for preparing same and application thereof
  • Self-setting calcium phosphate micro spheres, method for preparing same and application thereof
  • Self-setting calcium phosphate micro spheres, method for preparing same and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] The steps of preparing self-curing calcium phosphate microspheres using gelatin and oxidized starch as binder include:

[0038] (1) Add gelatin particles (Sinopharm Chemical Reagent Co., Ltd., F20071019, chemically pure) to 42°C deionized water at a ratio of 4g / 100mL to fully swell, and stir with a stirrer. After the gelatin particles are completely dissolved, Obtain a 4% (w / v) gelatin solution;

[0039] (2) Add oxidized starch granules (Shanghai Huipu Industrial Chemicals Co., Ltd., chemically pure) to 39°C deionized water at a ratio of 0.2g / 100mL to fully swell, and stir with a stirrer until the oxidized starch granules are completely After dissolving, a 0.2% (w / v) oxidized starch solution is obtained;

[0040] (3) The gelatin solution obtained in step (1) and the oxidized starch solution obtained in step (2) are mixed in equal volumes to obtain gelatin / oxidized starch solution as calcium phosphate bone cement blend (wherein the concentrations of gelatin and oxidized...

Embodiment 2

[0051] The steps of preparing self-curing calcium phosphate microspheres using gelatin and carboxymethyl starch as a binder include:

[0052] (1) Add gelatin particles (Sinopharm Chemical Reagent Co., Ltd., F20071019, chemically pure) to 39°C deionized water at a ratio of 6g / 100mL to fully swell, and stir with a stirrer. After the gelatin particles are completely dissolved, Obtain a 6% (w / v) gelatin solution;

[0053] (2) Add carboxymethyl starch granules (Guangzhou Jinzhujiang Chemical Co., Ltd., chemically pure) to 40°C deionized water at a ratio of 0.6g / 100mL to fully swell, and stir with a stirrer until carboxymethyl After the starch granules were completely dissolved, a 0.6% (w / v) carboxymethyl starch solution was obtained;

[0054] (3) The gelatin solution obtained in step (1) and the carboxymethyl starch solution obtained in step (2) are mixed in equal volumes to obtain gelatin / carboxymethyl starch solution as calcium phosphate bone cement blend (wherein gelatin and ca...

Embodiment 3

[0065] The steps for preparing self-curing calcium phosphate microspheres using gelatin and hydroxypropyl starch as a binder include:

[0066] (1) Add gelatin particles (Sinopharm Chemical Reagent Co., Ltd., F20071019, chemically pure) to 60°C deionized water at a ratio of 8g / 100mL to fully swell, and stir with a stirrer. After the gelatin particles are completely dissolved, Obtain 8% (w / v) gelatin solution;

[0067] (2) Add hydroxypropyl starch granules (Shanghai Huipu Industrial Chemicals Co., Ltd., chemically pure) to 40°C deionized water at a ratio of 1.2g / 100mL to fully swell, and stir with a stirrer until the hydroxypropyl starch After the starch granules were completely dissolved, a 1.2% (w / v) hydroxypropyl starch solution was obtained;

[0068] (3) The gelatin solution obtained in step (1) and the hydroxypropyl starch solution obtained in step (2) are mixed in equal volumes to obtain a gelatin / hydroxypropyl starch solution as a calcium phosphate bone cement blend (whe...

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Abstract

The invention discloses self-setting calcium phosphate micro spheres, a method for preparing the same and application thereof. The preparation method comprises the following steps of: mixing glutin and deionized water to obtain solution of glutin; mixing polysaccharide gum and deionized water to obtain solution of polysaccharide gum; mixing completely dissolved solution of glutin and solution of polysaccharide gum to obtain solution of glutin/polysaccharide gum; fully mixing the solution of glutin/polysaccharide gum and calcium phosphate cement by stirring to obtain pasty self-setting calciumphosphate slurry, fully dispersing the self-setting calcium phosphate slurry into soybean oil by stirring, removing the soybean oil by filtration, and repeatedly washing the micro spheres by acetone and alcohol to obtain the wet micro spheres; and performing curing hydration and drying of the wet micro spheres to obtain the self-setting calcium phosphate micro spheres. The method has the advantages that: the sintering treatment of the micro spheres is unnecessary, medicaments, growth factors or other active (functional) components can be synchronously loaded in the preparation process, the grain size of the obtained self-setting calcium phosphate micro spheres is 0.12 to 2.61mm, and the obtained self-setting calcium phosphate micro spheres are not disintegrated in 6 to 32 hours.

Description

technical field [0001] The invention belongs to the field of medical materials for bone defect repair, and in particular relates to a self-solidifying calcium phosphate microsphere and a preparation method and application thereof. Background technique [0002] The particle size of the microspheres used in the field of dental surgery is usually 0.25-1 mm, and the diameter of the microspheres used in plastic surgery is usually 1-2 mm. In order to meet the clinical requirements of filling and restoration in dental and plastic surgery, it is necessary to develop a particle size between 0.25 and 2mm, which has good biocompatibility, good degradability, fillability, easy handling and convenient loading functions Bone repair material microspheres with active ingredients. [0003] Ca-P salt microspheres with a smooth surface (commonly HA, β-TCP or biphasic calcium phosphate ceramic microspheres) are easy to fill due to their good fluidity, and their regular spherical structure allo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/12A61L27/54A61K6/033A61K6/838
Inventor 叶建东李江波李继彦王迎军
Owner SOUTH CHINA UNIV OF TECH
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