Preparation for feather keratin membrane and use of feather keratin membrane as medicament carrier

A keratin and drug technology, applied in the polymer field, can solve the problems of unstable structure, unsuitable for injection drug, low drug loading rate, etc., and achieve the effects of good mechanical properties, low cost, and easy peeling

Inactive Publication Date: 2010-09-22
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Microspheres are suitable for chemical embolization and local injection, but not for injection; liposomes can be used in a variety of drug delivery routes and preparations, and when used as an anticancer drug carrier, the drug can selectively kill cancer cells and improve the curative effect, but Its structure is unstable, easily absorbed by reticuloendothelial cells, and the drug loading rate is low

Method used

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  • Preparation for feather keratin membrane and use of feather keratin membrane as medicament carrier
  • Preparation for feather keratin membrane and use of feather keratin membrane as medicament carrier
  • Preparation for feather keratin membrane and use of feather keratin membrane as medicament carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]Embodiment 1: take by weighing 0.8g feather keratin powder, add 15mL secondary water wherein, add the mass concentration 1.5% sodium hydroxide solution of 8mL (the speed of dropping and the speed of stirring should be slower, contribute to like this The rapid dissolution of keratin, and the chemical properties of keratin will not change during the dissolution process), until the keratin powder is completely dissolved to obtain a keratin solution; Adjust to 7.3 (acid drop rate should also be appropriate, should not be too fast or too slow), then add 0.8g plasticizer, 0.002g rhodamine B to the keratin solution, stir at room temperature for 30min, make the keratin The protein solution, plasticizer, and drug are fully mixed to obtain a keratin drug film solution; finally, the keratin drug film solution is poured into a petri dish with a diameter of 8 cm, and a film is formed at 80°C.

[0036] The mechanical properties of the keratin drug-loaded film prepared in this example ...

Embodiment 2

[0037] Embodiment 2: take by weighing 0.8g feather keratin powder, add 15mL secondary water wherein, add the mass concentration 1.5% sodium hydroxide solution of 8mL (the speed of dropping and the speed of stirring should be slow, contribute to like this The rapid dissolution of keratin, and the chemical properties of keratin will not change during the dissolution process), until the keratin powder is completely dissolved to obtain a keratin solution; Adjust to 8.5 (acid drop rate should also be appropriate, should not be too fast or too slow), then add 0.8g plasticizer, 0.005g rhodamine B to the keratin solution, stir at room temperature for 30min, make the keratin The protein solution, plasticizer, and drug are fully mixed to obtain a keratin drug film solution; finally, the keratin drug film solution is poured into a petri dish with a diameter of 8 cm, and a film is formed at 80°C.

[0038] The mechanical properties of the keratin drug-loaded film prepared in this example a...

Embodiment 3

[0039] Embodiment 3: take by weighing 0.8g feather keratin powder, add 15mL secondary water wherein, add the mass concentration 1.5% sodium hydroxide solution of 8mL (the speed of dropping and the speed of stirring should be slow, contribute to like this The rapid dissolution of keratin, and the chemical properties of keratin will not change during the dissolution process), until the keratin powder is completely dissolved to obtain a keratin solution; Adjust to 9.3 (acid drop rate should also be appropriate, should not be too fast or too slow), then add 0.8g plasticizer, 0.012g rhodamine B to the keratin solution, stir at room temperature for 30min, make the keratin The protein solution, plasticizer, and drug are fully mixed to obtain a keratin drug film solution; finally, the keratin drug film solution is poured into a petri dish with a diameter of 8 cm, and a film is formed at 80°C.

[0040] The mechanical properties of the keratin drug-loaded film prepared in this example a...

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Abstract

The invention provides a method for preparing a feather keratin membrane, which belongs to the technical field of polymer processing. The method comprises the following steps of: dissolving feather keratin powder serving as raw material in alkali; then adjusting the pH value to between 7 and 14 with acid solution; and adding plasticizer into the mixture to form the membrane a culture dish. The method has the characteristics of simple process and low cost; and the keratin prepared by the method has biodegradability and good mechanical properties, is easy to peel, and can be used as the medicament carrier for the preparation of membrane medicament. Experiment shows that the membrane agent medicament prepared by taking the feather keratin membrane as the carrier have large loading capacity and high releasing speed.

Description

technical field [0001] The invention belongs to the technical field of macromolecules, and relates to a keratin film and a preparation method thereof; at the same time, the invention also relates to the application of the keratin film as a carrier in the preparation of film medicines. Background technique [0002] Since the 1960s, the research on drug controlled release system has attracted more and more attention. Compared with the traditional drug delivery mode, the controlled release of drugs has many advantages, which can not only improve the effectiveness, accuracy, and safety of drug therapy, but also significantly reduce the side effects and production costs of drugs. [0003] The biocompatible polymer carrier materials currently used in the medical field are mainly synthetic biodegradable polymer systems and natural macromolecular systems. In recent years, there have been many reports on microspheres (particle size greater than 1 μm), liposomes, polymer micelles, et...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L89/00C08L71/08C08K5/053C08J5/18A61K9/70A61K47/42
Inventor 王荣民王小洁李芳莹何玉凤李晓晓
Owner NORTHWEST NORMAL UNIVERSITY
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