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Preparation method of composite whitening lipid nanoparticle emulsion

A lipid nanoparticle, whitening technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve problems such as extensive use of active substances, poor stability, crystallization, etc., and is conducive to skin absorption and stability. Good sex, increase the effect of transdermal absorption rate

Active Publication Date: 2012-11-14
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the whitening agent tetrahydrocurcumin has the problem of poor stability, and it is very easily oxidized in water-containing cosmetics. If the mass percent of tetrahydrocurcumin 40% ethanol aqueous solution is 0.15%, it will be placed at room temperature for 14 days, and the color of the solution will change. Dark brown, this property of being easily oxidized seriously hinders its use in cosmetics
Glycyrrhiza glabra root extract and tetrahydropiperine are soluble in ethanol. The solubility of the two substances in water is less than 0.1%, and the solubility in oils commonly used in cosmetics is very small. If they are directly added to cosmetic oils, even if they are dissolved at high temperature, they will recover It is also easy to crystallize at room temperature, which directly affects the wide use of these active substances in cosmetics

Method used

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  • Preparation method of composite whitening lipid nanoparticle emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method of composite whitening lipid nanoparticle emulsion adopts the following steps:

[0023] A. Weigh 18.0g hydrogenated soybean oil (HYDROGENATED SOYBEAN OIL), 16.0g stearic acid monoglyceride (GLYCERYL STEARATE) in a beaker, heat in a water bath at 75°C to obtain a liquid oil phase;

[0024] B. Weigh 4.2g tetrahydrocurcumin, 2.7g licorice root extract, 0.6g tetrahydropiperine by the ratio of 7: 4.5: 1, add it to the above-mentioned liquid oil phase, and control the stirring speed to be 500rpm, stir for 5 minutes, stir and mix evenly, and keep at 75°C; in this example, the ratio of composite whitening active substance: lipid material is 0.22:1;

[0025] C. take the ratio of emulsifier and distilled water mass ratio of 0.11:1 to weigh 12.0g polyglycerol-4 stearate (POLYGLYCERYL-4 STEARATE), 4.5g sucrose stearate (SUCROSE STEARATE) and 150.0g distilled water, Put it into a beaker, heat it to 75°C, and stir to obtain a liquid water phase;

[0026] D. Mix...

Embodiment 2

[0029] A preparation method of composite whitening lipid nanoparticle emulsion adopts the following steps:

[0030] A. Weigh 9.0g hydrogenated soybean oil (HYDROGENATED SOYBEAN OIL) and 13.0g stearic acid monoglyceride (GLYCERYL STEARATE) in a beaker and heat in a water bath at 85°C to obtain a liquid oil phase;

[0031] B. Weigh 2.8g tetrahydrocurcumin, 0.9g licorice root extract, 0.3g tetrahydropiperine in a ratio of 9.3: 3: 1, add them to the above-mentioned liquid oil phase, and control the stirring speed to be 500rpm, stir for 5 minutes, stir and mix evenly, and keep at 85°C; in this example, the ratio of complex whitening actives: lipid material is 0.182:1;

[0032] C. Take the ratio of emulsifier and distilled water mass ratio of 0.16:1 to weigh 12g steareth-2 (STEARETH-2), 6.8g ceteth-10 (CETETH-10), 3.5g isohard Stearyl ether-20 (ISOSTEARETH-20), 1.2g ceteareth-40 (CETEARETH-40), 0.5g steareth-100 (STEARETH-100), 150.0g distilled water, put in In a beaker, heat to 8...

Embodiment 3

[0036] A preparation method of composite whitening lipid nanoparticle emulsion adopts the following steps:

[0037] A. Weigh 18g MURUMURU SEED BUTTER, 7.8g hydrogenated soybean oil (YDROGENATED SOYBEAN OIL), 4.6g hydrogenated sweet almond oil (HYDROGENATED SWEET ALMOND OIL), 4.6g hydrogenated wheat germ oil ( HYDROGENATED WHEAT GERM OIL) and 15.0 g of GLYCERYL STEARATE were placed in a beaker and heated in a water bath at 80°C to obtain a liquid oil phase;

[0038] B. According to the ratio of 15.6: 12.4: 1, take by weighing 7.8g tetrahydrocurcumin, 6.2g licorice root extract, 0.5g tetrahydropiperine, add it to the above-mentioned liquid oil phase, control the stirring speed at 500 rpm, stir for 5 minutes, stir and mix evenly, and keep at 80 ° C; in this example, the complex whitening active substance: lipid material = 0.29: 1;

[0039] C. Take the ratio of emulsifier and distilled water mass ratio of 0.155:1, weigh 5.6g polyglycerol-2 isostearate (POLYGLYCERYL-2 ISOSTEARATE)...

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Abstract

The invention relates to a preparation method of a composite whitening lipid nanoparticle emulsion, which mainly comprises the following steps of: (A) weighing lipid materials, and heating to 75-85 DEG C to obtain a liquid oil phase; (B) proportionally weighing tetrahydrocurcumin, glycyrrhiza glabra root extract and tetrahydropiperine and mixing to obtain a composite whitening active matter; (C) adding the composite whitening active matter into the liquid oil phase, and mixing uniformly; (D) weighing an emulsifier and distilled water, heating to 75-85 DEG C, and mixing uniformly to obtain a liquid water phase; and (E) mixing the liquid oil phase and the liquid water phase, carrying out circular homogenization for 5-15 times through a high-pressure homogenizer under the conditions that thepressure is 70-150MPa and the temperature is 75-90 DEG C, keeping the temperature of the mixed liquid at the outlet section of the high-pressure homogenizer to be lower than 90 DEG C, cooling to roomtemperature, and adding a proper amount of preservative so as to obtain the composite whitening lipid nanoparticle emulsion. The emulsion prepared by the preparation method provided by the invention has good stability and obvious whitening effect, basically does not discolor, and is convenient to be blended in a cosmetic formula in a cooling mode.

Description

technical field [0001] The invention relates to the technical field of lipid nanoparticle preparation, in particular to a preparation method of a composite whitening lipid nanoparticle emulsion. Background technique [0002] Orientals regard white as beauty, and whitening skin care products occupy an important position in the entire cosmetics industry. However, the application of whitening active ingredients in cosmetics often has certain limitations, such as poor stability, weak skin penetration, low solubility, and difficult compatibility. For example: Tetrahydrocurcumin is extracted from Indian turmeric, which is a highly effective whitening active ingredient, as well as anti-oxidation and UV protection; Glycyrrhiza glabra root extract is a flavonoid extracted from Glycyrrhiza glabra. It can effectively inhibit the activity of various enzymes in the process of melanin production, especially the activity of tyrosinase. It also has the effect of preventing skin roughness a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/49A61K8/35A61K8/06A61Q19/02
Inventor 蒋丽刚陆海英王亚龄
Owner PROYA COSMETICS
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