The invention discloses a
silicon-containing conjugated olefin compound as well as a preparation method and application thereof, the
structural formula of the
silicon-containing conjugated olefin compound is shown as (I), and the
silicon-containing conjugated olefin compound is obtained by carrying out silicon-carbon bond breakage synthesis on an allenyl functionalized silicon
hybrid quaternary compound in the presence of a ligand, a
palladium catalyst and a reaction medium, the
allene functionalized silicon
hybrid quaternary compound is used as a reactant to directly perform
intramolecular reaction under the action of a complex formed by a
metal catalyst and a
phosphine ligand, the reaction condition is mild, the method is simple, and the obtained crude product can be purified by a
silica gel rapid
chromatography to obtain a pure product. The method has the advantages of mild
reaction conditions, wide substrate expansion range, simple preparation operation and the like, and the prepared compound has a certain application prospect in the anti-tumor field.